[PDF] Inflammation Associated Depression Evidence Mechanisms And Implications eBook

Author : Robert Dantzer
Publisher : Springer
Page : 357 pages
File Size : 18,5 MB
Release : 2016-12-28
Category : Medical
ISBN : 3319511521

GET BOOK

Inflammation has invaded the field of psychiatry. The finding that cytokines are elevated in various affective and psychotic disorders brings to the forefront the necessity of identifying the precise research domain criteria (RDoCs) that inflammation is responsible for. This task is certainly the most advanced in major depressive disorders. The reason is that a dearth of clinical and preclinical studies has demonstrated that inflammation can cause symptoms of depression and conversely, cytokine antagonists can attenuate symptoms of depression in medical and psychiatric patients with chronic low grade inflammation. Important knowledge has been gained on the symptom dimensions that inflammation is driving and the mechanisms of action of cytokines in the brain, providing new targets for drug research and development. The aim of the book “Inflammation-Associated Depression” is to present this field of research and its implications in a didactic and comprehensive manner to basic and clinical scientists, psychiatrists, physicians, and students at the graduate level.

Author : Bernhard Baune
Publisher : Academic Press
Page : 638 pages
File Size : 29,93 MB
Release : 2018-05-23
Category : Medical
ISBN : 0128110740

GET BOOK

Inflammation and Immunity in Depression: Basic Science and Clinical Applications is the first book to move beyond the established theory of cytokine-induced depression and explore the broader role the immune system plays in this devastating mood disorder. The book fully explores the most recent lines of research into this rapidly advancing field, including alterations of T-cells, the neurobiological implications of neuroinflammation and immune alterations for brain development and function, and the genetic components of neuroinflammation in depression, including the relationships between stress and inflammation that are revealing gene-environment interactions in the disorder. Combining contributions from researchers worldwide, this book provides the most comprehensive discussion available today on the involvement of the innate immune and adaptive immune systems in depressive disorder. Chapters span neuroscience, psychology, clinical applications and future directions, making this book an invaluable resource for advanced students, researchers and practitioners who need to understand the complex and varied role of inflammation and immune responses in depression. Synthesizes current knowledge of inflammation and immunity in depression, ranging from basic neuroscience research, to clinical applications in psychiatry Expands on the long-established theory of cytokine-induced depression to discuss broader involvement of the immune system Explores translational potential of targeting immune dysfunction for clinical interventions

Author : A. Halaris
Publisher : Karger Medical and Scientific Publishers
Page : 218 pages
File Size : 22,9 MB
Release : 2013-02-27
Category : Medical
ISBN : 3318023116

GET BOOK

Psychoimmunology is a rapidly maturing area of scientific endeavor that provides a compelling integrative link between the immune system and its response to stress and psychiatric illness. Stress initiates pathological changes by activating the immune and endocrine systems. Inflammation is at the core of the complex and interactive systems that both contribute to and result from psychopathology. Consequently, inflammation research advances our knowledge of the pathology of depression, schizophrenia, chronic fatigue syndrome, posttraumatic stress disorder and a host of co-morbid conditions, notably diabetes, cardiovascular disease and cerebrovascular disease. The possible mechanisms underlying the bidirectionality of co-morbid medical and psychiatric disorders can be viewed as a consequence of inflammatory changes. These emerging novel concepts illustrate how the knowledge of inflammation can enable meaningful integration of psychopathology with physical co-morbidity. The innovative articles in this volume highlight the intricate link between psychiatry and psychoimmunology and underscore the central role of inflammation in furthering our understanding of the pathophysiology underlying mental health and illness.

Author : Edward Bullmore
Publisher : Macmillan + ORM
Page : 239 pages
File Size : 24,8 MB
Release : 2018-12-31
Category : Psychology
ISBN : 1250318157

GET BOOK

As seen on "CBS This Morning" Worldwide, depression will be the single biggest cause of disability in the next twenty years. But treatment for it has not changed much in the last three decades. In the world of psychiatry, time has apparently stood still...until now with Edward Bullmore's The Inflamed Mind: A Radical New Approach to Depression. A Sunday Times (London) Top Ten Bestseller In this game-changing book, University of Cambridge professor of psychiatry Edward Bullmore reveals the breakthrough new science on the link between depression and inflammation of the body and brain. He explains how and why we now know that mental disorders can have their root cause in the immune system, and outlines a future revolution in which treatments could be specifically targeted to break the vicious cycles of stress, inflammation, and depression. The Inflamed Mind goes far beyond the clinic and the lab, representing a whole new way of looking at how mind, brain, and body all work together in a sometimes misguided effort to help us survive in a hostile world. It offers insights into how we could start getting to grips with depression and other mental disorders much more effectively in the future.

Author : Institute of Medicine
Publisher : National Academies Press
Page : 488 pages
File Size : 39,34 MB
Release : 2009-10-28
Category : Medical
ISBN : 0309121787

GET BOOK

Depression is a widespread condition affecting approximately 7.5 million parents in the U.S. each year and may be putting at least 15 million children at risk for adverse health outcomes. Based on evidentiary studies, major depression in either parent can interfere with parenting quality and increase the risk of children developing mental, behavioral and social problems. Depression in Parents, Parenting, and Children highlights disparities in the prevalence, identification, treatment, and prevention of parental depression among different sociodemographic populations. It also outlines strategies for effective intervention and identifies the need for a more interdisciplinary approach that takes biological, psychological, behavioral, interpersonal, and social contexts into consideration. A major challenge to the effective management of parental depression is developing a treatment and prevention strategy that can be introduced within a two-generation framework, conducive for parents and their children. Thus far, both the federal and state response to the problem has been fragmented, poorly funded, and lacking proper oversight. This study examines options for widespread implementation of best practices as well as strategies that can be effective in diverse service settings for diverse populations of children and their families. The delivery of adequate screening and successful detection and treatment of a depressive illness and prevention of its effects on parenting and the health of children is a formidable challenge to modern health care systems. This study offers seven solid recommendations designed to increase awareness about and remove barriers to care for both the depressed adult and prevention of effects in the child. The report will be of particular interest to federal health officers, mental and behavioral health providers in diverse parts of health care delivery systems, health policy staff, state legislators, and the general public.

Author : Alexander Choukèr
Publisher : Springer Nature
Page : 756 pages
File Size : 28,30 MB
Release : 2019-11-27
Category : Medical
ISBN : 3030169960

GET BOOK

This book explains how stress – either psychological or physical – can activate and/or paralyse human innate or adaptive immunity. Adequate immunity is crucial for maintaining health, both on Earth and in space. During space flight, human physiology is specifically challenged by complex environmental stressors, which are most pronounced during lunar or interplanetary missions. Adopting an interdisciplinary approach, the book identifies the impact of these stressors – the space exposome – on immunity as a result of (dys-)functions of specific cells, organs and organ networks. These conditions (e.g. gravitation changes, radiation, isolation/confinement) affect immunity, but at the same time provide insights that may help to prevent, diagnose and address immune-related health alterations. Written by experts from academia, space agencies and industry, the book is a valuable resource for professionals, researchers and students in the field of medicine, biology and technology. The chapters “The Impact of Everyday Stressors on the Immune System and Health”, “Stress and Radiation Responsiveness” and “Assessment of Radiosensitivity and Biomonitoring of Exposure to Space adiation” are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Author : Francisco Lopez-Munoz
Publisher : CRC Press
Page : 521 pages
File Size : 31,81 MB
Release : 2011-09-09
Category : Medical
ISBN : 143983850X

GET BOOK

Major depressive disorders have recently been associated with impairments in signaling pathways that regulate neuroplasticity and cell survival. Agents designed to directly target molecules in these pathways hold promise as new therapeutics for depression. With the collaboration of the most prestigious international specialists in biochemistry, mol

Author : Wayne Katon
Publisher : John Wiley & Sons
Page : 197 pages
File Size : 17,93 MB
Release : 2011-06-09
Category : Medical
ISBN : 1119957478

GET BOOK

In recent years, there has been a growing awareness of the multiple interrelationships between depression and various physical diseases. The WPA is providing an update of currently available evidence on these interrelationships by the publication of three books, dealing with the comorbidity of depression with diabetes, heart disease and cancer. Depression is a frequent and serious comorbid condition in diabetes, which adversely affects quality of life and the long-term prognosis. Co-occurrent depression presents peculiar clinical challenges, making both conditions harder to manage. Depression and Diabetes is the first book devoted to the interaction between these common disorders. World leaders in diabetes, depression and public health synthesize current evidence, including some previously unpublished data, in a concise, easy-to-read format. They provide an overview of the epidemiology, pathogenesis, medical costs, management, and public health and cultural implications of the comorbidity between depression and diabetes. The book describes how the negative consequences of depression in diabetes could be avoided, given that effective depression treatments for diabetic patients are available. Its practical approach makes the book ideal for all those involved in the management of these patients: psychiatrists, psychologists, diabetologists, general practitioners, diabetes specialist nurses and mental health nurses.

Author : Samantha Lawes
Publisher :
Page : 0 pages
File Size : 45,78 MB
Release : 2020
Category :
ISBN :

GET BOOK

There is extensive evidence linking inflammation with depression, but the nature of this relationship remains unclear. This PhD consisted of two studies that aimed to investigate the interaction of immune and neuroendocrine function in major depressive disorder (MDD) and examine the effects of depressive symptoms and inflammation on mortality risk. Study 1 sought to garner more information about the relationship between immune activation and HPA-axis function using data from an observational, case-control study including people with MDD and healthy controls. In Study 1a differences in inflammatory cytokines and HPA-axis function, and associations between them were examined. Results indicated increased inflammation, a flattened cortisol awakening response under the curve (CAR AUC) and impaired corticosteroid function in depressed people. Furthermore there was evidence of a negative association between inflammation and diurnal cortisol rhythm. In Study 1b changes in depressive symptoms, inflammatory cytokines and HPA-axis function were investigated longitudinally in people with MDD. The results demonstrated an improvement in depressive symptoms and mineralocorticoid sensitivity. We also observed a trend towards an improvement in the CAR AUC and an apparent trend towards a negative pattern of association between change in inflammation and change in the CAR. In Study 1c differences in Treg frequency were assessed between people with MDD and healthy controls. The findings showed no difference between the groups and no association with either inflammation or HPA-axis function. Study 2 investigated the combined effects of depressive symptoms and inflammation on CVD and all-cause mortality risk in a longitudinal cohort study of older people. The results showed that the combination of both factors confers a considerable increase in CVD mortality risk for men. Together these studies indicate that there is a relationship between inflammation and HPA-axis dysfunction in MDD and that men with depressive symptoms and increased inflammation constitute a high-mortality risk phenotype.

Author : Robert Dantzer
Publisher : Springer Science & Business Media
Page : 334 pages
File Size : 34,81 MB
Release : 1999-07-31
Category : Medical
ISBN : 0306461358

GET BOOK

Until a few years ago, cytokines were only known to immunologists; now these molecules have burst upon neurosciences and permeated several avenues of current research. This book examines the possible role of cytokines in mental depression, based on recent clinical and experimental data, and constitutes the first attempt to make a synthesis between the exciting new developments in cytokine research and their implications for the pathophysiology of mental disorders.