[PDF] In Vivo Replication Status Of Equine Infectious Anemia Virus During Experimental Infection eBook

Author :
Publisher :
Page : 26 pages
File Size : 31,81 MB
Release : 1995
Category :
ISBN :

GET BOOK

We have used the equine infectious anemia virus (EIAV) system to antibody dependent enhancement (ADE) of lentivirus replication and disease by experimental EIAV vaccines, as an animal model for human AIDS vaccine studies. During the current project period we have performed in parallel experimental immunizations of Shetland ponies with several EIAV glycoprotein subunit vaccines to evaluate the risk of enhancement by the different subunit vaccines. The results of these studies demonstrate a high propensity for immune enhancement in ponies immunized with a baculovirus expressed recombinant gp9O vaccine or with a subunit vaccine containing HPLC-purified viral gp90. Th contrast, a subunit vaccine based containing both of the EIAV envelope proteins (gp9O and gp45) and purified by lectin affinity chromatography produced a high degree of protection against virus challenge. Using immune serum from these immunized ponies, we have also developed in vitro ADE assays and evaluated the correlation of these assays with in vivo enhancement. Although the in vitro ADE assay remains to be optimized, initial results suggest that in vitro ADE assays may in fact distinguish between enhancing and protective immune responses in experimentally vaccinated ponies.

Author : Debra C. Sellon
Publisher : Elsevier Health Sciences
Page : 664 pages
File Size : 36,45 MB
Release : 2013-10-01
Category : Medical
ISBN : 1455751154

GET BOOK

Ideal for both practitioners and students, this comprehensive resource covers the diagnosis, treatment, and prevention of infectious disease in horses. Organized by infectious agent — virus, bacterial and rickettsial, protazoal, and fungal — it includes complete coverage of the individual diseases caused by each type of agent. A section on clinical problems examines conditions such as ocular infections, CNS infections, and skin infections. It also addresses the importance of preventing and controlling infectious disease outbreaks with coverage of epidemiology, biosecurity, antimicrobial therapy, and recognizing foreign equine diseases. Full-color photos and illustrations provide clear, accurate representations of the clinical appearance of infectious diseases. Features the most recent information on the global threat of newly emergent diseases such as African Horse Sickness. Includes a comprehensive section on the prevention and control of infectious diseases. More than 60 expert contributors share their knowledge and expertise in equine infectious disease. A companion CD-ROM, packaged with the book, includes complete references linked to PubMed.

Author : Herman Friedman
Publisher : Springer Science & Business Media
Page : 445 pages
File Size : 46,12 MB
Release : 2007-04-27
Category : Medical
ISBN : 0387257411

GET BOOK

An AIDS vaccine is still elusive and HIV treatment continues to develop multidrug resistance at alarming rates. Because of the similarities between HIV and immune deficiency infections in a variety of animals, it is only natural that scientists use these animals as models to study pathogenesis, treatment, vaccine development and many other aspects of HIV. Part of the series Infectious Agents and Pathogenesis, this volume reviews the immune deficiency virus in a variety of hosts. Pathogenesis, vaccine and drug development, epidemiology, and the natural history of the monkey, mouse, cat, cow, horse, and other animal viruses are detailed and compared to HIV. Also included are chapters on the history and future of animal models, as well as a chapter on ethical and safety considerations in using animal models for AIDS studies.

Author : Jagadeesh Bayry
Publisher : Springer
Page : 440 pages
File Size : 26,24 MB
Release : 2017-02-07
Category : Medical
ISBN : 331947426X

GET BOOK

This book provides comprehensive knowledge on diseases in livestock that are caused by viruses, parasites and bacteria. Emerging and re-emerging pathogens are presented in detail for various animal groups and in-depth insights into pathogenesis and epidemiology will be provided for each of them. In addition, state-of-the-art treatment possibilities, control measures as well as vaccination strategies are discussed. The recent years have witnessed a sharp increase in the number of emerging and re-emerging infectious diseases of livestock and many of these, including Influenza, Corona and Hanta are of public health importance. The reasons for this development are manifold:changes in the climate, life cycle of vectors and increased global travel. Also, due to extensive deforestation, livestock are increasingly coming in direct contact with wild animals that are reservoirs of many emerging pathogens. Recent progress in diagnosis and management of emerging infectious diseases are also topic of this book.