[PDF] Idiotypes And Anti Idiotypes As Probes In Analysis Of Immunoregulation eBook

Author : Morris Reichin
Publisher : Elsevier
Page : 417 pages
File Size : 47,42 MB
Release : 2012-12-02
Category : Science
ISBN : 032315137X

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Idiotypes documents the proceedings of an International Conference on Idiotypes held in Oklahoma City, Oklahoma, at the Oklahoma Medical Research Foundation, October 20-23, 1985. The aims of the conference were to gather active investigators in the study of idiotypes; to assess progress in the field; and to explore directions for future research. The papers presented at the conference cover a wide range of subjects. Several papers deal with defining protein and DNA sequences which determine idiotypes. Evidence points to germ line genes encoding the V region structures which underlie idiotypy. Another subtheme which concerns several contributions is the occurrence of dominant idiotypes in induced immune responses (e.g., arsonate and lysozyme) and autoimmunity (e.g., thyroglobulin and rheumatoid factors). The presence of such dominant idiotypes is discussed from several viewpoints, but the recurrent theme is that such dominance is a manifestation of a selection process inherent in the idiotypic network. Two papers deal with idiotypic structures in T cells: on the one hand, identifying idiotypes on T helper cells and, on the other, I-J and Iat related structures which tightly govern cellular interactions in the evolution of an immune response. Network interactions through autoanti-idiotypic responses are shown to be associated with the effects on the specificity of both induced and naturally occurring immune responses. Autoanti-idiotypic responses are also shown to be correlated with the regulation of the anti-DNA response in human systemic lupus erythematosus. These data pointed to a role of the idiotype network in immune regulation.

Author : Mark Greene
Publisher : Springer Science & Business Media
Page : 498 pages
File Size : 35,32 MB
Release : 2013-11-11
Category : Medical
ISBN : 1468447394

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The phenomenon of idiotypy was discovered almost thirty years ago, but it was only during the past decade that it attracted widespread interest and became the subject of numerous research investigations. From the outset, much of the interest in idiotypy was based on its implications with respect to the repertoire of antibodies. Kunkel showed, for example, that idiotypes associated with certain human myeloma or Bence-Jones proteins were present in normal human globulins at levels of less than one part per million. Also, Oudin's original definition of idiotypy implied that idiotypes could be uniquely associated with individual rabbits as well as with particular antigen-binding specificities. Such observations provided some of the earliest evidence for an extensive repertoire of immunoglobulin molecules. The implications of these findings have been amply confirmed by recent studies of protein struc ture and molecular genetics; many of these studies are reviewed in the present volume. It is known now that the diversity of antibodies is based on the presence of numerous V and L V H genes, on recombinatorial events involving D and] segments, on somatic mutations, and on processes involving deletion of DNA followed by repair with errors, including inser tions. Each of these parameters is capable of influencing the idiotype expressed by the final immunoglobulin product. Regulation of the immune response is another area in which idiotypy has significantly influenced modern immunology.

Author : Constantin A. Bona
Publisher : CRC Press
Page : 194 pages
File Size : 23,17 MB
Release : 2018-01-18
Category : Health & Fitness
ISBN : 1351078674

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The goal of this book is to present findings which are supportive of the concept that the words of the idiotype dictionary and likewise self-recognition are essential for communication between lymphocyte clones while some unfaithful ( infidel ) copies of the words contained in the idiotype dictionary perhaps play a role in the functional regulation of nonlymphoid cells.

Author : Constantin A. Bona
Publisher : CRC Press
Page : 516 pages
File Size : 19,2 MB
Release : 2018-01-18
Category : Health & Fitness
ISBN : 1351087134

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The goal of this book is to present findings which are supportive of the concept that the words of the idiotype dictionary and likewise self-recognition are essential for communication between lymphocyte clones while some unfaithful ( infidel ) copies of the words contained in the idiotype dictionary perhaps play a role in the functional regulation of nonlymphoid cells.

Author : Constantin A. Bona
Publisher : Wiley-Interscience
Page : 312 pages
File Size : 42,75 MB
Release : 1987-03-11
Category : Medical
ISBN :

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Presents the major theoretical aspects and experimental findings supporting the network theory of immune response. Explains the concept of regulatory idiotopes and their roles in physiological and pathological phenemona and then gives practical applications of idiotype concepts to the preparation of vaccines, to understanding the basis of autoimmune diseases, to cancer therapy, and to the study of receptors for hormones, vitamins, and other biologically active substances. The information contained in this text will be valuable to any student or specialist who is devoted to understanding the relationship between the immune system and other systems in the body.

Author : Daniel Gomez
Publisher : Frontiers E-books
Page : 88 pages
File Size : 35,9 MB
Release :
Category :
ISBN : 2889191184

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Actively induced immunotherapy is one of the most promising fields in cancer research and numerous approaches are being studied to design effective cancer vaccines. Among the treatment strategies to develop an effective immune response against tumor associated antigens is the use of anti idiotype (Ab2) mAb as antigen surrogates. Several studies in animal models have demonstrated the efficacy of these vaccines for triggering the immune system to induce specific and protective immunity against tumors of different origin. In fact, anti-idiotypic mAbs have been used successfully in cancer therapeutics to overcome the poor immunogenicity of some tumor-associated antigens, in particular those of non-protein origin. In some clinical trials, including patients with different tumors, anti-Id specific humoral and/or cellular responses following immunization were associated with improved clinical outcome. This number of Frontiers will be dedicated to anti- idiotypic antibodies and their use in cancer treatment. Different article types will be considered: original contributions, case reports, methods, hypothesis and theory, reviews, historical, etc.

Author : Ralph Reisfeld
Publisher : Springer Science & Business Media
Page : 318 pages
File Size : 29,48 MB
Release : 2013-11-11
Category : Medical
ISBN : 1468437615

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Information about histocompatibility antigens is expanding so rapidly that of all advances. In these volumes, we have it is difficult to remain abreast made an effort to bring together the most current work on topics that have generated most of the recent advances and discussions. We have asked each author to present and interpret his most current work, and we have judiciously refrained from imposing our own prejudices and viewpoints. Although there is obvious overlap in some individual topics, we have encouraged this to provide the reader with as many different and some times opposing viewpoints as possible. This approach will, we hope, give a broad overview of current ideas in the field. We wish to thank all contributors for their timely and exciting manu scripts, and we sincerely hope that the reader will benefit from these volumes. R. A. Reisfeld S. Ferrone La Jolla vii Contents I. Role of Histocompatibility Antigens in Cell-Cell Interaction Chapter 1 Histocompatibility Antigens and the T-Cell Repertoire . . . . . . . . . . . . . . 3 Harald von Boehmer 1. Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. H-2 Restriction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. 1. H-2 Restriction of T Cells. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. 2. B Cells Are Not H-2-Restricted . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 3. H-2-Linked Ir Genes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 3. 1. Influence on the T-Cell Repertoire . . . . . . . . . . . . . . . . . . . . . . . . 5 3. 2. H-2-Gene Complementation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 3. 3. The B-Cell Repertoire Is Not Directly Influenced by H-2-Linked Ir Genes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 4. Frequency of Cells Specific for Allogeneic H-2 Antigens . . . . . . . . 12 4. 1. Allospecific T Cells. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 4. 2. Allospecific B Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .