[PDF] Horizons In Clinical Pharmacology eBook

Author : Alan G E Wilson
Publisher : Royal Society of Chemistry
Page : 444 pages
File Size : 50,14 MB
Release : 2015-11-20
Category : Medical
ISBN : 1782622373

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Drug metabolism, pharmacokinetics and toxicokinetics as determinants of drug attrition and the safety of xenobiotics are critically important. This book presents a comprehensive treatise on the current issues and challenges facing drug metabolism and pharmacokinetics. Readers will find a thorough exploration of their predictive role in impacting drug discovery and development and in improving the success rate and safety assessment of pharmaceuticals and industrial or occupational chemicals. Chapters not only focus on the current state of art, with distinct examples, but on future needs and approaches likely to improve our prediction of potential human risk. Discussions of critical properties that are determinants of a compound’s metabolic and pharmacokinetic fate follow introductory chapters. The Drug Discovery process increasingly incorporates pharmacokinetics and drug metabolism screening and focus has shifted towards in silico, computational and systems biology approaches. Core chapters reflect this and the recent interest and need to assess the role of transporters, along with drug metabolizing enzymes, as potential determinants of pharmacokinetic behaviour, toxicity and drug-drug interactions. Lastly, chapters cover the issues and factors involved in translating pharmacokinetics from in silico to in vivo and from animal models to man, and postulate future directions and opportunities. Leading experts from academia, industry and regulatory bodies across the globe contribute their knowledge to this book, which scientists involved in many aspects of the drug discovery process, as well as regulators and postgraduate students, will find a useful resource.

Author : Constance G Visovsky
Publisher : Elsevier Health Sciences
Page : 402 pages
File Size : 13,76 MB
Release : 2018-03-19
Category : Medical
ISBN : 032354990X

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NEW! Chapter on Eye and Ear Medications focuses on important glaucoma treatments. NEW! Dosage ranges added to drug tables reinforce safe medication administration NEW! Top tips for safety and clinical care provide you with advice from practicing nurses in applicable situations. NEW! Expanded content on cultural considerations help you think about ethnic differences that may relate to each drug class. NEW! Drug and IV calculation questions test your knowledge of dosages and calculations.

Author : Annegret Hannawa
Publisher : Walter de Gruyter GmbH & Co KG
Page : 268 pages
File Size : 18,44 MB
Release : 2017-12-18
Category : Medical
ISBN : 3110454505

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This case studies book is an indispensable resource for educators, students, and practitioners of nursing. It is innovative in its application of lessons from the communication sciences to common challenges in the delivery of safe patient care. The authors apply basic tenets of human communication to the context of nursing to provide a foundation for practices that can advance the safety and quality of care. The cases, which describe "close calls" and adverse events, are organized along the continuum of healthcare delivery, providing quick access to solutions in commonly encountered care situations. Each case is accompanied by a discussion of how skillful communication can be key to preventing and recovering from errors and adverse events. Thought-provoking discussion questions and references for further reading make this book a valuable reference for nursing educators, students, and practitioners across the world.

Author : Shiew-Mei Huang
Publisher : Academic Press
Page : 649 pages
File Size : 13,17 MB
Release : 2012-09-18
Category : Medical
ISBN : 0123854725

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Principles of Clinical Pharmacology is a successful survey covering the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This essential reference continues to focus on the basics of clinical pharmacology for the development, evaluation, and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the third edition has been thoroughly updated to provide readers with an ideal reference covering the wide range of important topics impacting clinical pharmacology as the discipline plays an increasingly significant role in drug development and regulatory science. The Third Edition has been endorsed by the American Society for Clinical Pharmacology and Therapeutics Includes new chapters on imaging and the pharmacogenetic basis of adverse drug reactions Offers an expanded regulatory section that addresses US and international issues and guidelines Provides extended coverage of earlier chapters on transporters, pharmacogenetics and biomarkers and also illustrates the impact of gender on drug response Presents a broadened discussion of clinical trials from Phase 1 to incorporate Phases II and III

Author : Morris J. Brown
Publisher : Elsevier Health Sciences
Page : 681 pages
File Size : 48,45 MB
Release : 2012-07-30
Category : Medical
ISBN : 0702051136

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A thorough knowledge of pharmacological and therapeutic principles is vital if drugs are to be used safely and effectively for increasingly informed patients. Those who clearly understand how drugs get into the body, how they produce their effects, what happens to them in the body, and how evidence of their therapeutic effect is assessed, will choose drugs more skilfully, and use them more safely and successfully than those who do not. Now in a fully revised 11th edition, Clinical Pharmacology is essential reading for undergraduate medical students, junior doctors and anyone concerned with evidence-based drug therapy. Introductory first three sections cover general principle of clinical pharmacology; five subsequent sections cover drug treatment of disease organised by body system. Retains approachable style set by the original author, Professor Laurence. Emphasis throughout is on evidence-based and safe drug prescribing. Indian Advisory Board will ensure content reflects the needs of the devloping world.

Author : Morris J. Brown
Publisher : Elsevier Health Sciences
Page : 688 pages
File Size : 49,89 MB
Release : 2018-03-22
Category : Medical
ISBN : 070207330X

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‘The very last thing a drug regulator wishes to be able to say is, like Lord Byron (1788-1824), on the publication of his poem Childe Harold’s Pilgrimage, ‘I awoke one morning and found myself famous.’ The twelfth edition of this long-established textbook of clinical pharmacology (first published in 1960) continues its fine tradition of balancing science and practice for improved evidence-based drug therapy and good prescribing in therapeutic settings increasingly complicated by intercurrent disease and polypharmacy. Coverage of all major therapeutic topics by body system. Introductory sections give brief chapter synopses. Case studies where relevant. Covers the needs of the developing world with a focus on practical prescribing and health technology assessment. Definition, tips, brief explanation boxes throughout. Interesting histories, etymologies and provenances of terms throughout. Entertaining footnotes throughout. ‘The very last thing a drug regulator wishes to be able to say is, like Lord Byron (1788-1824), on the publication of his poem Childe Harold’s Pilgrimage, ‘I awoke one morning and found myself famous.’ Fully updated throughout. New co-editor: Fraz Mir, Addenbrooke’s Hospital and Department of Medicine, University of Cambridge, Royal College of Physicians Associate International Director for South Asia. Now with free e-book on StudentConsult.

Author : Alan G. E. Wilson
Publisher : Royal Society of Chemistry
Page : 711 pages
File Size : 34,48 MB
Release : 2012
Category : Medical
ISBN : 1849730512

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The sophistication of modelling and simulation technologies have improved dramatically over the past decade and their applications in toxicity prediction and risk assessment are of critical importance. The integration of predictive toxicology approaches will become increasingly necessary as industrial chemicals advance and as new pharmaceuticals enter the market. In this comprehensive discussion of predictive toxicology and its applications, leading experts express their views on the technologies currently available and the potential for future developments. The book covers a wide range of topics including in silico, in vitro and in vivo approaches that are being used in the safety assessment of chemical substances. It reflects the growing and urgent need to strengthen and improve our ability to predict the safety and risks posed by industrial and pharmaceutical chemicals in humans. The reader will find extensive information on the use of current animal models used for various toxicities and target mediated toxicities. Also discussed are the recent regulatory initiatives to improve the safety assessment of chemicals. The book provides an expert and comprehensive discussion on the current status and future directions of predictive toxicology and its application. The various chapters in the book also reflect the growing need for improvements in our technologies and abilities to predict toxicities of pharmaceutical and industrial chemicals to ensure product safety and protect public health.