[PDF] Homocysteine In Protein Structure Function And Human Disease eBook

Author : Hieronim Jakubowski
Publisher : Springer Science & Business Media
Page : 175 pages
File Size : 31,69 MB
Release : 2013-06-20
Category : Science
ISBN : 3709114101

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Excess of homocysteine, a product of the metabolism of the essential amino acid methionine, is associated with poor health, is linked to heart and brain diseases in general human populations, and accelerates mortality in heart disease patients. Neurological and cardiovascular abnormalities occur in patients with severe genetic hyperhomocysteinemia and lead to premature death due to vascular complications. Although it is considered a non-protein amino acid, studies over the past dozen years have discovered mechanisms by which homocysteine becomes a component of proteins. Homocysteine-containing proteins lose their normal biological function and become auto-immunogenic and pro-thrombotic. In this book, the author, a pioneer and a leading contributor to the field, describes up-to date studies of the biological chemistry of homocysteine-containing proteins, as well as pathological consequences and clinical implications of their formation. This is a comprehensive account of the broad range of basic science and medical implications of homocysteine-containing proteins for health and disease. ​

Author : Govind Prasad Dubey
Publisher : Springer Nature
Page : 285 pages
File Size : 12,14 MB
Release : 2022-05-12
Category : Medical
ISBN : 9811668671

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This book comprehensively reviews the association of homocysteine metabolism with the etiology of various human disorders. The well-defined chapters embedded the central and peripheral effects of homocysteine metabolism intricately related with cardiovascular, neurodegenerative, metabolic, and autoimmune disorders. Further, it discusses the mechanisms of perturbance of cellular proteostasis by elevated homocysteine levels and provides a comprehensive account of pathophysiological consequences and clinical implications of homocysteine-containing proteins. The book also reviews association of genetic variants of homocysteine metabolic genes with type 2 diabetes mellitus and obesity. It also describes the molecular mechanism of hyperhomocysteinemia in the negative/feedback regulation of neural stem cell proliferation and alterations in DNA methylation. Taken together, it summarizes the mechanisms of hyper homocysteinemia-induced endothelial dysfunction and physiological functions of hydrogen sulfide as the protective agent.

Author : K. Robinson
Publisher : Springer Science & Business Media
Page : 480 pages
File Size : 43,93 MB
Release : 2000-04-30
Category : Medical
ISBN : 9780792362487

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This state-of-the-art review provides an in-depth and critical summary of homocysteine from its molecular basis to clinical relevance and current clinical trials of folic acid and vitamin B6. Written by leading workers in the field, the book provides an authoritative, comprehensive and thoroughly up-to-date overview for scientists and clinicians and any others engaged in the field. It will also be useful to anyone involved in managing vascular patients or cardiac risk factors, as well as biochemists, pharmacologists, general physicians, cardiologists and clinical and basic researchers with an interest in preventive medicine.

Author : Ralph Carmel
Publisher : Cambridge University Press
Page : 558 pages
File Size : 44,45 MB
Release : 2001-07-19
Category : Medical
ISBN : 9780521653190

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This is an unusually comprehensive 2001 account of the broad range of medical implications of homocysteine.

Author : Tanveer Ali Dar
Publisher : Academic Press
Page : 0 pages
File Size : 47,74 MB
Release : 2019-05-21
Category : Science
ISBN : 9780128119136

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Protein Modificomics: From Modifications to Clinical Perspectives comprehensively deals with all of the most recent aspects of post-translational modification (PTM) of proteins, including discussions on diseases involving PTMs, such as Alzheimer's, Huntington's, X-linked spinal muscular atrophy-2, aneurysmal bone cyst, angelman syndrome and OFC10. The book also discusses the role PTMs play in plant physiology and the production of medicinally important primary and secondary metabolites. The understanding of PTMs in plants helps us enhance the production of these metabolites without greatly altering the genome, providing robust eukaryotic systems for the production and isolation of desired products without considerable downstream and isolation processes.

Author : Dominic J. Harrington
Publisher : Academic Press
Page : 340 pages
File Size : 23,47 MB
Release : 2018-11-28
Category : Medical
ISBN : 0128130512

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Laboratory Assessment of Vitamin Status provides a comprehensive understanding of the limitations of commonly used approaches used for the evaluation of vitamin status, reducing harm in the general health setting. It outlines the application of ‘Best Practice’ approaches to the evaluation of vitamin status, giving physicians and other healthcare professionals the opportunity to make evidence-based interventions. Nearly every metabolic and developmental pathway in the human body has a dependency on at least one micronutrient. Currently, the clinical utility of approaches taken by laboratories for the assessment of vitamin status is generally poorly understood, missing the opportunity to diagnosis vitamin deficiencies. This essential reference gives clinical and biomedical scientists an understanding of the limitations of commonly used approaches to the evaluation of vitamin status in the general health setting through change in practice. Nutritionists and dietitians gain an understanding of more sophisticated markers of vitamin status. Describes specialist assays in sufficient detail to enable laboratories to replicate what is being performed by expert groups Provides detailed information that supports laboratories in the setting up of methods for the evaluation of vitamin status Informs laboratories looking for third party providers of specialist investigations Provides an essential overview of reference ranges for each vitamin

Author : Krasimir Kolev
Publisher : BoD – Books on Demand
Page : 210 pages
File Size : 42,32 MB
Release : 2014-05-07
Category : Medical
ISBN : 9535112651

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This book familiarizes the reader with some recent trends in the theory and practice of thrombolysis. It covers the field of fibrinolysis from the standpoint of basic scientists and clinicians and delivers the state-of-the-art information on the biochemistry and pharmacology of fibrinolysis, as well as related novel methodological and diagnostic tools in the field. An introductory chapter summarizes the basic molecular mechanisms in fibrinolysis (plasminogen, its endogenous activators and their inhibitors, plasmin and its inhibitors). Recent developments in our understanding of fibrin formation are described in the context of its impact on fibrinolysis. The discussion of neutrophil extracellular traps in the modulation of fibrin assembly and the consequences regarding plasminogen activation and plasmin action addresses a novel aspect of fibrinolysis.