[PDF] Histogenesis And Precursors Of Human Gastric Cancer eBook

Author : Mitsumasa Nishi
Publisher : Springer Science & Business Media
Page : 451 pages
File Size : 21,43 MB
Release : 2013-11-09
Category : Medical
ISBN : 4431683283

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Gastric cancer is still the most common cause of cancer death in the world, although in most countries, with the notable exception of the United States, its incidence is slowly declining. In statistical terms, gastric cancer is therefore the most formidable of cancer types, and its control is a pressing issue. Recent evidence indicates that the conversion of normal cells to so-called "clinical cancer" is the prerequisite for a multistage process which is intimately associated with an accumulation of multiple gene alterations including both oncogenes and tumor-suppressor genes. Gastric cancer is no exception, in that it reveals multiple gene changes whose scenario differs, depending on their occurrence in intestinal-type or diffuse-type gastric cancers. This book was planned for publication by the Japanese Research Society for Gastric Cancer in order to shed light on basic research and clinical practice in gastric cancer. The individual chapters, written by a variety of experts, contain numerous new topics related to all aspects of the disease, including epidemiology, experimental carcinogenesis, pathology, biology, diagnosis, and treatment. It is hoped that this book will be of use in basic research, pathological diagnosis, early detection, and therapy of gastric cancer. We would like to thank the staff of Springer-Verlag Tokyo for the excellent technical production.

Author : P.I. Reed
Publisher : Springer Science & Business Media
Page : 194 pages
File Size : 42,62 MB
Release : 2012-12-06
Category : Medical
ISBN : 9400921675

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Despite the fact that the incidence of gastric cancer is declining in the Western world, it remains a significant problem with respect to accurate diagnosis and treatment since it has a high mortality rate. In June 1989 an International Conference was held at the University of Rome "La Sapienza" entitled "New Trends in Gastric Cancer: Background and videosurgery". During this meeting background information on the aetiopathogenesis of gastric cancer was presented together with talks and video presentations on the latest advances in the treatment of gastric carcinoma, both from the European and Japanese experience. Because of the poor prognosis of gastric carcinoma there is increasing pressure for early detection. Some of the problems in the early detection of gastric carcinoma are discussed together with methods of surveillance of high-risk subjects. It is generally accepted that the surgical approach to gastric carcinoma should take into account the site and extent of the lesion and there are chapters on new methods for pre and intraoperative staging of the disease which allow a more logical approach to surgery. A comparison between Japanese and Western rule and results was attempted and reasons for the differences were investigated. Since the field is still evolving not all aspects could be covered, and those angles not approached in this book will be addressed in a second International Conference to be held in Rome in June 1990.

Author : Ying-Chang Zhang
Publisher : Springer Science & Business Media
Page : 185 pages
File Size : 32,33 MB
Release : 2012-12-06
Category : Medical
ISBN : 3642774954

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In this book, precursors of gastric cancer are described histopathologically, especially about the precancerous conditons and precancerous lesions of the stomach. In addition to those precancerous changes stated in previous monographs and textbooks, some newly recognized gastric dysplasias are proposed. In order to be able to ovjectively evaluate the atypism of dysplasic changes, achievements of morphometric studies were presented.

Author : Robert Riddell
Publisher : Lippincott Williams & Wilkins
Page : 3502 pages
File Size : 23,64 MB
Release : 2014-05-14
Category : Medical
ISBN : 1451154437

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Lewin’s Gastrointestinal Pathology and Its Clinical Implications, Second Edition This comprehensive, two-volume resource highlights the practical aspects the pathology of biopsies and gross specimens, the clinical/pathological correlation, and differential diagnoses, and the ways in which these affect the management of patients with gastrointestinal disorders. The authors provide valuable insights on many important areas of gastrointestinal pathology, and openly address controversies within the specialty. This all-inclusive work stands alone in its illustrative quality and in its emphasis on the clinical implications of patient management as related to pathologic findings. The Second Edition has been completely revised to reflect two decades of advances in the field. The book’s focus on clinical/pathological correlations and differential diagnoses emphasizes their affect on patient management. Major revisions of the chapters on colitis and gastritis feature new approaches to treatment. Over 2100 full-color illustrations highlight pathologic features to sharpen diagnostic skills and guide treatment choices. NEW to the Second Edition... Completely revised content reflects two decades of advances in the field. Focus on clinical/pathological correlations and differential diagnoses emphasizes their affect on patient management Major revisions of the chapters on colitis and gastritis feature new approaches to treatment. Over 2100 full-color illustrations highlight pathologic features to sharpen diagnostic skills and guide treatment choices.

Author : Eiichi Tahara
Publisher : Springer Science & Business Media
Page : 360 pages
File Size : 38,9 MB
Release : 2013-06-29
Category : Medical
ISBN : 4431659153

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Twenty years have passed since I became a professor in the First Department of Pathology, Hiroshima University School of Medicine. It is my great pleas ure that Molecular Pathology o[ Gastroenterological Cancer-Application to Clinical Practice has been published by Springer-Verlag Tokyo to commemo rate the 20th anniversary of my professorship. Seeing the academic achievements of our department during these 20 years, I am confident that we could establish a department of oncology to research the pathogenesis of human cancer through systemic application of a variety of molecular techniques. We have demonstrated that the develop me nt and progression of esophageal, gastric, and colon cancer require mul tiple alterations affecting DNA mismatch repair genes, oncogenes, and tumorsuppressor genes, and that common and uncommon genetic changes exist for esophageal, gastric, and colorectal carcinomas. In addition to these genetic changes, the majority of gastrointestinal cancers express telomerase activity, with overexpression of telomerase RNA, indicating a powerful addi tional tool for early detection of gastrointestinal cancer. By transferring these basic observations to the clinic, we now are able to make accurate cancer diagnoses, thus determing the grade of malignancy and patient prognosis. We also can identify patients at high risk for developing cancer and create new therapeutic approaches. In fact, we have routinely implemented a new molecular diagnosis strategy at the Hiroshima City Medi cal Association Clinical Laboratory since August 1993.