[PDF] High Throughput Screening For Novel Anti Inflammatories eBook

Author : Michael Kahn
Publisher : Birkhäuser
Page : 290 pages
File Size : 13,16 MB
Release : 2012-12-06
Category : Science
ISBN : 3034884621

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Combinatorial chemistry in conjunction with High Throughput Screening (HTS) is revolutionizing the drug discovery process. Yet, we have much to learn about the integration of these powerful techniques with information from genomics, proteomics, computation and pharmacokinetics before dramatic increases in the drug discovery/development processes can be achieved. The chapters in this book represent the state of the art regarding the integration of combinatorial chemistry and HTS in connection with anti-inflammatory targets. Obviously, there is much work to be done beyond what is described in this text, nevertheless, it should set the stage for creative thinking among scientists of many disciplines for the accomplishment of our ultimate goals in treating inflammatory diseases.

Author : William P. Janzen
Publisher : Methods in Molecular Biology
Page : 292 pages
File Size : 32,29 MB
Release : 2009-07-09
Category : Juvenile Nonfiction
ISBN :

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Featuring new screening technologies as well as many well established methods, this book offers comprehensive treatment of the activities directly related to High Throughput Screening (HTS), such as compound library management, data handling, and robotics.

Author : Johan Zaagsma
Publisher : Springer
Page : 288 pages
File Size : 39,99 MB
Release : 2013-03-08
Category : Medical
ISBN : 3034883587

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What are the different muscarinic acetylcholine receptor subtypes and how are they distributed in the airways and molecular signalling mechanisms? What is their function in neurogenic and non-neurogenic control of the airways and in inflammatory mechanisms? How is their gene expression regulated? The great importance of muscarinic acetylcholine receptors for the pathophysiology and treatment of chronic inflammatory obstructive airways diseases calls for a comprehensive and integrated overview of the current knowledge to address such questions, to discuss the role of these receptor subtypes in diseases such as asthma and COPD, and to present novel perspectives on antimuscarinic drug development. The present book is the worthy result of this need. It points out innovative insights into the hitherto poorly understood role of postjunctional muscarinic M2 receptors in airway smooth muscle contraction and sheds some light on the novel concepts of antimuscarinic drug development, with special reference to the l

Author : Klaus Ley
Publisher : Springer Science & Business Media
Page : 314 pages
File Size : 48,25 MB
Release : 2007-10-27
Category : Medical
ISBN : 3764379758

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This volume gives a comprehensive overview on the most relevant leukocyte and endothelial adhesion molecules. The chapters are written by leaders in the field and focus on the biology, structure, function, and regulation of adhesion molecules. Currently approved adhesion molecule-based therapies are reviewed and an outlook for future approaches is also provided. The book is of interest to clinicians and scientists from immunology, physiology, cancer research, rheumatology, allergology, infectious diseases, gastroenterology, pulmonology and cardiology.

Author : Carla A. F. M. Bruijnzeel-Koomen
Publisher : Springer Science & Business Media
Page : 224 pages
File Size : 45,62 MB
Release : 2000
Category : Allergy
ISBN : 9783764359706

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Allergic skin diseases belong to the most common dermatoses. This book deals with fundamental (in particular, immunological aspects), as wel l as clinical symptoms and therapeutic strategies of the allergic skin diseases.

Author : Luke A.J. O'Neill
Publisher : Springer Science & Business Media
Page : 254 pages
File Size : 34,69 MB
Release : 2006-03-16
Category : Medical
ISBN : 3764374411

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A repertoire of 10 TLRs mediate the first response to all microbes that infect mammals. They are the long sought receptors for a wide range of microbial products. Notable examples include TLR4 which recognizes LPS from gram negative bacteria, TLR3 which recognizes viral double-stranded RNA and TLR9 which recognizes CpG DNA motifs, found commonly in both viruses and bacteria. TLRs are increasingly being implicated in both infectious and inflammatory diseases, notable examples being sepsis, inflammatory bowel disease, atherosclerosis and asthma. There is therefore great interest in targeting TLRs therapeutically since blocking TLRs will result in a decrease in the production of inflammatory mediators such as TNF. This volume covers our current understanding of TLRs, and their role in inflammation. Given the primacy of TLRs in the inflammatory process and their emerging role in inflammatory diseases the book is of great interest to researchers working in inflammation and immunology.

Author : Giora Z. Feuerstein
Publisher : Springer
Page : 351 pages
File Size : 17,53 MB
Release : 2012-12-06
Category : Medical
ISBN : 3034882971

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Stroke is a leading cause of death in developed countries. However, current therapeutic strategies for stroke have been largely unsuccessful. One possible explanation is that research and pharmacological management have focused on very early events in brain ischemia. New research has shown that brain ischemia and trauma elicit strong inflammatory reactions driven by both external and brain cells. The recognition of inflammation as a fundamental response to brain ischemia provides novel opportunities for new anti-inflammatory therapies. For the first time, an international body of researchers presents the latest findings about the cellular and humoral aspects of immune and inflammatory reactions in the brain. The work may have an impact on the treatment of neuroinjuries and ancillary brain diseases, and increase the understanding of the roles infections and immune reactions play in the brain milieu.

Author : Rikard Holmdahl
Publisher : Springer Science & Business Media
Page : 182 pages
File Size : 14,72 MB
Release : 2006-07-02
Category : Medical
ISBN : 3764374195

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Rheumatoid Arthritis (RA) represents a complex disease where the inheritable component has been estimated to be up to 60%. This PIR volume deals with the genetic basis and regulation of rheumatic diseases. The first part of the book describes genetic studies on rheumatic diseases. The second part deals with the shared heredity of rheumatic diseases, e.g., RA, lupus and ankylosing spondylitis. The third part of the volume describes tools for analysing genetic complexity, ranging from animal models to new molecular tools. The volume is essential reading for researchers and clinicians from rheumatology, inflammation research, immunology, and cell and molecular biology.

Author : Trevor T. Hansel
Publisher : Springer
Page : 238 pages
File Size : 11,40 MB
Release : 2012-12-06
Category : Medical
ISBN : 3034879393

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Chronic obstructive pulmonary disease (COPD) ranges amongst the commonest diseases in the world. The relentless progression of the disease causes a pressing need for a better understanding of and therapies for COPD. This volume provides state-of-the-art information on the pathophysiology of COPD including an outlook on new therapies. It is of interest to researchers and clinicians in academia as well as in the pharmaceutical industry.