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Author : Emma Raven
Publisher : Royal Society of Chemistry
Page : 388 pages
File Size : 26,62 MB
Release : 2015-10-27
Category : Science
ISBN : 1849739110
This book will provide an up to date handbook that is unique in its combination of both the general aspects of heme protein structure and the function in a single volume.
Author : Clare Hawkins
Publisher : CRC Press
Page : 464 pages
File Size : 37,60 MB
Release : 2021-10-08
Category : Medical
ISBN : 1000450635
Mammalian heme peroxidase enzymes play a critical role in innate immune responses and disease prevention. The formation of potent chemical oxidants is essential to this protective physiologic activity in immunity. Although highly beneficial in the context of immune defense, it is now well established that peroxidases and their overproduction of oxidants contribute to the initiation and persistence of many chronic inflammatory conditions in the cardiovascular, neurologic, respiratory, renal, and gastrointestinal systems. Peroxidasins, a protein family related to heme peroxidases, play a novel role in tissue biogenesis and matrix assembly, which are also attracting attention in different pathological contexts. Given the diverse roles of mammalian heme peroxidases and the breadth and incidence of pathologies associated with these enzymes, there has been significant interest in modulating peroxidase activity as a therapeutic strategy. This book highlights recent developments in our understanding of the chemistry, biochemistry and biological roles of mammalian peroxidases and their associated oxidants, their involvement in both innate immunity and chronic inflammatory disease in a variety of end organs, and potential therapeutic approaches to modulate and prevent damaging reactions. Key Features Structure and biosynthesis of mammalian peroxidases Reactivity of hypohalous acids with biological substrates Peroxidases in innate immunity Peroxidases in human pathology Modulation of peroxidase-induced biological damage
Author : H. Brian Dunford
Publisher :
Page : 507 pages
File Size : 19,44 MB
Release : 1999
Category : Peroxidase
ISBN :
Author : Eduardo Torres
Publisher : Springer Science & Business Media
Page : 360 pages
File Size : 31,96 MB
Release : 2010-08-20
Category : Science
ISBN : 3642126278
The last systematic description of heme peroxidases was published in 1999 by Brian Dunford, from the University of Alberta in Canada. The book Heme per- idases covers discussion on three-dimensional structure, reaction mechanism, kinetics, and spectral properties of representative enzymes from bacterial, plant, fungal, and animal origin. Since 1999, vast information on basic but also applied aspects of heme peroxidases has been generated. We believe fusion of these two aspects will bene?t research of those dedicated to development of biocatalytic process. The aim of this book is to present recent advances on basic aspects such as evolution, structure–function relation, and catalytic mechanism, as well as applied aspects, such as bioreactor and protein engineering, in order to provide the tools for rational design of enhanced biocatalysts and biocatalytic processes. The book does not include an exhaustive listing of references but rather a selected collection to enrich discussion and to allow envisioning future directions for research. This book is organized in three parts. In Part I, current knowledge of structure and mechanism of peroxidases is covered. From the molecular phylogeny, going through the in?uence of structural factors over oxidative ability to the molecular mechanism of catalysis, the authors intend to provide an understanding of per- idases at the molecular level. The understanding of the fundamental behavior of peroxidases will allow further adequation, design, and/or optimization of pero- dase-based catalysis to a particular process. In Part II, research on potential applications of peroxidases in several ?elds is presented and discussed.
Author : Clare Hawkins
Publisher : CRC Press
Page : 340 pages
File Size : 10,42 MB
Release : 2021-10-07
Category : Medical
ISBN : 1000450619
Mammalian heme peroxidase enzymes play a critical role in innate immune responses and disease prevention. The formation of potent chemical oxidants is essential to this protective physiologic activity in immunity. Although highly beneficial in the context of immune defense, it is now well established that peroxidases and their overproduction of oxidants contribute to the initiation and persistence of many chronic inflammatory conditions in the cardiovascular, neurologic, respiratory, renal, and gastrointestinal systems. Peroxidasins, a protein family related to heme peroxidases, play a novel role in tissue biogenesis and matrix assembly, which are also attracting attention in different pathological contexts. Given the diverse roles of mammalian heme peroxidases and the breadth and incidence of pathologies associated with these enzymes, there has been significant interest in modulating peroxidase activity as a therapeutic strategy. This book highlights recent developments in our understanding of the chemistry, biochemistry and biological roles of mammalian peroxidases and their associated oxidants, their involvement in both innate immunity and chronic inflammatory disease in a variety of end organs, and potential therapeutic approaches to modulate and prevent damaging reactions. Key Features Structure and biosynthesis of mammalian peroxidases Reactivity of hypohalous acids with biological substrates Peroxidases in innate immunity Peroxidases in human pathology Modulation of peroxidase-induced biological damage
Author : George Georgiou
Publisher :
Page : 248 pages
File Size : 17,3 MB
Release : 1991
Category : SCIENCE
ISBN :
the refolding process is often the critical bottleneck in the production of high-value proteins, and recently acquired insights have yet to be translated into technological advantages. These proceedings bridge the gap between fundamental and applied studies, addressing such issues as in vivo protein folding, protein aggregation and inclusion body formation, elucidation of the folding pathway, characterization of folding intermediates, and practical considerations in protein renaturation. The symposium was part of the 199th ACS National Meeting, Boston, April 1990. Annotation copyrighted by Book News, Inc., Portland, OR
Author : Johannes Everse
Publisher : CRC Press
Page : 280 pages
File Size : 18,75 MB
Release : 1990-10-24
Category : Medical
ISBN : 9780849369643
The second of two relatively independent volumes on the chemistry and biology of peroxidases. Volumes 2 covers the peroxidases isolated from plants and microorganisms, and includes detailed discussions of some of the unique reactions catalyzed by these enzymes. Volume one covered the peroxidases isolated from animal sources, as well as the "pseudo- peroxidase activity" of prostaglandin H synthase and of myoglobin and hemoglobin. Acidic paper. Annotation copyrighted by Book News, Inc., Portland, OR
Author : J. A. Cowan
Publisher : John Wiley & Sons
Page : 458 pages
File Size : 47,83 MB
Release : 1997-03-21
Category : Science
ISBN : 9780471188957
Das erfolgreiche Werk des jungen, kreativen Autors jetzt in aktualisierter und korrigierter Auflage! Der Text wurde um Fragenkomplexe und Übungsbeispiele, teils mit Lösungen, erweitert; dies empfiehlt ihn besonders zur Ergänzung einer Vorlesung.
Author : Eduardo Torres
Publisher :
Page : pages
File Size : 16,40 MB
Release : 2010
Category :
ISBN : 9783642126284
This monograph describes many applications of peroxidase-based biocatalysis in the biotechnology industry. The need for such a book emerges from the considerable amount of new data regarding the phylogeny, reaction mechanisms, thermodynamic characterization and structural features of fungal and plant heme peroxidases that has been generated in the past 10 years, since the last specialized book on peroxidases was published. The aim of this book is to present recent advances on such basic aspects as evolution, structure-function relation and catalytic mechanism as well as applied aspects, such as bioreactor and protein engineering, to provide the tools for rational design of enhanced biocatalysts and biocatalytic processes.
Author : J. N. Rodríguez López
Publisher : EDITUM
Page : 310 pages
File Size : 46,73 MB
Release : 2003-05-12
Category : Mathematics
ISBN : 9788483713792
Plant Peroxidases: Biochemistry and Physiology recoge los últimos avances en el campo de las peroxidasas vegetales. Las peroxidasas son un grupo de enzimas que se encuentran ampliamente distribuidas en toda la escala filogenética y catalizan la oxidación de un amplio número de sustratos orgánicos e inorgánicos, utilizando el poder oxidante del peróxido de hidrógeno. Además de su interés académico y fisiológico, estas enzimas son ampliamente utilizadas en laboratorios clínicos y en la industria. El presente libro consta de 47 artículos de investigaciónen en los que se tratan diversos aspectos de las peroxidasas como su estructura, enzimología genética, fisiología, localización y aplicaciones. Las aportaciones a este libro han sido realizadas por especialistas de todo el mundo que se reunieron en Murcia en el año 2002 durante el Congreso titulado VI International Plant Peroxidase Symposium