[PDF] Handbook Of Molecular Genetic Techniques For Brain And Behavior Research eBook

Author : Wim E. Crusio
Publisher : Elsevier
Page : 994 pages
File Size : 29,97 MB
Release : 1999-10-18
Category : Psychology
ISBN : 0080536867

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The book gives a broad overview of recombinant DNA techniques for the behavioral neuroscientist, with illustrative examples of applications. Species covered include rodents (mainly mice), Drosophila melanogaster, Caenorhabditis elegans and Danio rerio. Experimental techniques required to characterize the behavioral phenotypes of mutant animals is provided. Several aspects of novel molecular-genetic techniques are overviewed and possible research strategies are explained. The sections of the book start with general descriptions of techniques followed by illustrative examples. It is divided into six sections. Section 1, bioinformatics and genomics research. Section 2, top-down strategies, where the researcher starts with the phenotype and then analyzes the associated genes; bottom-up strategies, where the physiological chain leading to a phenotype is analyzed starting from the gene product. Section 3, transgenic approaches in rodents including overexpressing foreign genes and gene-targeting; systemic manipulation approaches directly targeting the central nervous system and methods used with invertebrates. Section 4, methods used to evaluate relevant behavioral phenotypes, including learning and aggression. Section 5, examples on molecular brain research in man. Section 6, ethical aspects of research in this field.

Author : Robert T. Gerlai
Publisher : Academic Press
Page : 710 pages
File Size : 29,36 MB
Release : 2018-04-24
Category : Mathematics
ISBN : 0128041161

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Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior, a critical piece of the puzzle for clinicians, scientists, course instructors and advanced undergraduate and graduate students. Chapters examine neuroinformatics, genetic and neurobehavioral databases and data mining, also providing an analysis of natural genetic variation and principles and applications of forward (mutagenesis) and reverse genetics (gene targeting). In addition, the book discusses gene expression and its role in brain function and behavior, along with ethical issues in the use of animals in genetics testing. Written and edited by leading international experts, this book provides a clear presentation of the frontiers of basic research as well as translationally relevant techniques that are used by neurobehavioral geneticists. Focuses on new techniques, including electrocorticography, functional mapping, stereo EEG, motor evoked potentials, optical coherence tomography, magnetoencephalography, laser evoked potentials, transmagnetic stimulation, and motor evoked potentials Presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior Written and edited by leading international experts

Author : Hemin R Chin
Publisher : CRC Press
Page : 360 pages
File Size : 34,55 MB
Release : 2019-12-18
Category :
ISBN : 9780367455132

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Authored by researchers in the forefront of the field, this book provides a guide for applying powerful molecular genetic techniques to the study of neural and behavioral systems. It supplies a foundation by which data on gene expression and function may be used to develop new therapeutic strategies for brain diseases. The book covers tools and tec

Author : Turhan Canli
Publisher : Oxford Library of Psychology
Page : 481 pages
File Size : 49,75 MB
Release : 2015
Category : Medical
ISBN : 0199753881

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This entry in the Oxford Library of Psychology compiles cutting- edge research organized around the concept "molecular psychology," which applies principles of molecular biology to the study of behavior and its neural underpinnings. Determining the biological bases for behavior, and the extent to which we can observe and explain their neural underpinnings, requires a bold, broadly defined research methodology. The interdisciplinary entries in this handbook are organized around the principle of "molecular psychology," which unites cutting-edge research from such wide-ranging disciplines as clinical neuroscience and genetics, psychology, behavioral neuroscience, and neuroethology. For the first time in a single volume, leaders in diverse research areas use molecular approaches to investigate social behavior, psychopathology, emotion, cognition and stress in healthy volunteers, patient populations, and an array of non-human species including rodents, insects, fish, and non-human primates. Chapters draw on molecular methods covering candidate genes, genome-wide association studies, copy number variations, gene expression studies, and epigenetics while addressing the ethical, legal, and social issues to emerge from this new and exciting research approach.

Author : Yong-Kyu Kim
Publisher : Springer Science & Business Media
Page : 557 pages
File Size : 49,50 MB
Release : 2009-03-25
Category : Medical
ISBN : 0387767274

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This handbook provides research guidelines to study roles of the genes and other factors involved in a variety of complex behaviors. Utilizing methodologies and theories commonly used in behavior genetics, each chapter features an overview of the selected topic, current issues, as well as current and future research.

Author : Matt Carter
Publisher : Academic Press
Page : 416 pages
File Size : 27,31 MB
Release : 2022-03-26
Category : Medical
ISBN : 0323915612

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Modern neuroscience research is inherently multidisciplinary, with a wide variety of cutting edge new techniques to explore multiple levels of investigation. This Third Edition of Guide to Research Techniques in Neuroscience provides a comprehensive overview of classical and cutting edge methods including their utility, limitations, and how data are presented in the literature. This book can be used as an introduction to neuroscience techniques for anyone new to the field or as a reference for any neuroscientist while reading papers or attending talks. Nearly 200 updated full-color illustrations to clearly convey the theory and practice of neuroscience methods Expands on techniques from previous editions and covers many new techniques including in vivo calcium imaging, fiber photometry, RNA-Seq, brain spheroids, CRISPR-Cas9 genome editing, and more Clear, straightforward explanations of each technique for anyone new to the field A broad scope of methods, from noninvasive brain imaging in human subjects, to electrophysiology in animal models, to recombinant DNA technology in test tubes, to transfection of neurons in cell culture Detailed recommendations on where to find protocols and other resources for specific techniques "Walk-through" boxes that guide readers through experiments step-by-step

Author : Douglas Wahlsten
Publisher : Academic Press
Page : 305 pages
File Size : 50,19 MB
Release : 2010-11-25
Category : Nature
ISBN : 0123756758

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Mouse Behavioral Testing: How to Use Mice in Behavioral Neuroscience provides detailed explanations of how to conduct an experiment on mouse behavior from the initial planning of the research design through every step of the process until the data analysis phase. The book discusses the practical matters that need to be considered carefully when working with any species of animal, such as how many animals need to be tested. It describes the tests and techniques devised specifically for work with mice. Every step of the research process is illustrated with real situations encountered in previous studies. All examples are based on real experiments, and extensive details of several published experiments are provided. The essential features of a behavioral test protocol are outlined, and several complete protocols are provided. Methods to balance the order of tests and determine throughput are described, then a completely balanced order of tests in a complex experiment is presented. The book will be useful for those already familiar with the general principles of research but are new to the realm of behavioral testing of live mice. It will also serve as a text for a formal course, most likely at the graduate level. A guide to running a behavioral testing lab, including the many aspects of mouse research beyond the confines of the specific test Diagrams and photographs are shown for many kinds of apparatus and test situations with sufficient details such as dimensions to enable building of replicas Provides step-by-step instructions on planning and executing behavioral experiments in order to run them successfully

Author : Michela Gallagher
Publisher : John Wiley & Sons
Page : 748 pages
File Size : 23,53 MB
Release : 2003-03-11
Category : Psychology
ISBN : 047126444X

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Includes established theories and cutting-edge developments. Presents the work of an international group of experts. Presents the nature, origin, implications, an future course of major unresolved issues in the area.

Author : Thomas Steckler
Publisher : Elsevier
Page : 864 pages
File Size : 35,18 MB
Release : 2005-03-24
Category : Medical
ISBN : 9780444511737

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The Handbook of Stress and the Brain focuses on the impact of stressful events on the functioning of the central nervous system; how stress affects molecular and cellular processes in the brain, and in turn, how these brain processes determine our perception of and reactivity to, stressful challenges - acutely and in the long-run. Written for a broad scientific audience, the Handbook comprehensively reviews key principles and facts to provide a clear overview of the interdisciplinary field of stress. The work aims to bring together the disciplines of neurobiology, physiology, immunology, psychology and psychiatry, to provide a reference source for both the non-clinical and clinical expert, as well as serving as an introductory text for novices in this field of scientific inquiry. Part 1 addresses basic aspects of the neurobiology of the stress response including the involvement of neuropeptide, neuroendocrine and neurotransmitter systems and its corollaries regarding gene expression and behavioural processes such as cognition, motivation and emotionality. * Provides an overview of recent advances made in stress research * Includes timely discussion of stress and its effect on the immune system * Presents novel treatment strategies targeting brain processes involved in stress processing and coping mechanisms