[PDF] Genomic And Molecular Cardiovascular Medicine eBook

Author : Dhavendra Kumar
Publisher : Elsevier
Page : 462 pages
File Size : 18,9 MB
Release : 2024-06-24
Category : Science
ISBN : 0128229209

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The Genomic and Molecular Cardiovascular Medicine largely focuses on pertinent genomic and molecular aspects of cardiovascular medicine relevant to all levels of clinical practice, from primary care to preventive healthcare. The book also focuses on practice applications of translational genomic and molecular developments and advances that impact on cardiovascular system structure and function. Each chapter is evidence-based and comprehensive, with in-depth, cutting-edge knowledge relevant to the practice of clinical cardiology and cardiovascular surgery. The book aims to fill a major gap of knowledge resource focused on genomic and molecular aspects of contemporary cardiovascular medicine and surgery practice. In view of scientific and technical complexities of the field, the book is written by a team of globally acknowledged experts in respective clinical, investigative, therapeutic and preventive aspects. The current practices within cardiovascular medicine and surgery offer excellent opportunity for genomic and molecular applications to achieve the high order effectiveness with maximum efficiency. Includes clinical applications of genomic and molecular new knowledge, along with advances in the practice of cardiovascular medicine and surgery Provides wide coverage of all major clinical and preventive aspects of clinical cardiology, including multi-disciplinary team care Focuses on targeted gene and molecular therapy in clinical cardiovascular medicine and surgery

Author : Dhavendra Kumar
Publisher : Springer
Page : 921 pages
File Size : 22,15 MB
Release : 2018-01-17
Category : Medical
ISBN : 3319661140

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This title reflects the exponential growth in the knowledge and information on this subject and defines the extensive clinical translation of cardiovascular genetics and genomics in clinical practice. This concise, clinically oriented text is targeted at a broad range of clinicians who manage patients and families with a wide range of heterogeneous inherited cardiovascular conditions. Cardiovascular Genetics and Genomics: Principles and Clinical Practice includes a concise and clear account on selected topics written by a team of leading experts on clinical cardiovascular genetics. Each chapter include key information to assist the clinician and case histories have been incorporated to reflect contemporary practice in clinical cardiovascular genetics and genomics. Therefore this will be of key importance to all professionals working in the discipline, from clinicians and trainees in cardiology, cardiac surgery, electrophysiology, immunology through geneticists, nursing staff and those involved in precision medicine.

Author : Victor J. Dzau, MD
Publisher : John Wiley & Sons
Page : 328 pages
File Size : 15,85 MB
Release : 2008-04-15
Category : Medical
ISBN : 0470765941

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Until recently, a modest knowledge of genetics was more than adequate for the daily practice of clinical cardiology, but advances in genetics and genomics are changing cardiovascular medicine in fundamental ways. The identification of the genetic basis of several forms of dyslipidemia, hypertension, diabetes, cardiomyopathies, and vascular diseases signalled the new importance of genetics in clinical medicine. In this timely volume, Drs. Dzau and Liew – both pioneers in the area – help cardiologists understand: • how cardiovascular genetics may remodel the way cardiovascular medicine is practiced • what material has immediate relevance to the practicing clinician • how to incorporate genetics and genomics in your practice to ensure up-to-date patient care The book opens with introductory chapters, then discusses: • cardiovascular single gene disorders • cardiovascular polygenic disorders • therapies and applications Outstanding contributors write on their areas of expertise, making Cardiovascular Genetics and Genomics for the Cardiologist both authoritative and comprehensive. If you want to gain a better appreciation of how genetics and genomics are already shaping current practice and may potentially revolutionize cardiology, look no further than this dependable reference.

Author : José Marín-García
Publisher : Academic Press
Page : 935 pages
File Size : 43,77 MB
Release : 2014-05-09
Category : Medical
ISBN : 0124046428

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In this second edition of Post-Genomic Cardiology, developing and new technologies such as translational genomics, next generation sequencing (NGS), bioinformatics, and systems biology in molecular cardiology are assessed in light of their therapeutic potential. As new methods of mutation screening emerge, both for the genome and for the “epigenome, comprehensive understanding of the many mutations that underlie cardiovascular diseases and adverse drug reactions is within our reach. This book, written by respected cardiologist José Marín-García, features discussion on the Hap-Map: the largest international effort to date aiming to define the differences between our individual genomes. This unique reference further reviews and investigates genome sequences from our evolutionary relatives that could help us decipher the signals of genes, and offers a comprehensive and critical evaluation of regulatory elements from the complicated network of the background DNA. Offers updated discussion of cutting-edge molecular techniques including new genomic sequencing / NGS / Hap-Map / bioinformatics / systems biology approaches Analyzes mitochondria dynamics and their role in cardiac dysfunction, up-to-date analysis of cardio-protection, and cardio-metabolic syndrome Presents recent translational studies, gene therapy, transplantation of stem cells, and pharmacological treatments in CVDs

Author : P.A.F.M. Doevendans
Publisher : Springer Science & Business Media
Page : 306 pages
File Size : 26,51 MB
Release : 2012-12-06
Category : Medical
ISBN : 1461510058

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Four years ago-in December 1997-the first European Science Foundation Workshop on Cardiovascular Specific Gene Expression was held in Maastricht. It was hardly possible to imagine the progress in the field in those four years. In 1997, gene expression was still an art focused on individual genes; in 200 I, many labs have access to micro-array facilities to determine the expression of thousands of genes simultaneously. In 1997, gene expression was an area of fundamental research in basis molecular biology laboratories; in 200 I, clinical cardiovascular research has incorporated gene expression approaches. In 1997, the interpretation of a gene expression experiment was usually straightforward; in 200 I, advanced bioinformatics tools are needed to approach the extreme complexities of genetic control of cell and tissue function. The second symposium in this series is focused on Cardiovascular Genomics. New Pathophysiological Concepts. The organizing committee chose to invite a group of renown scientists and young investigators around four topics of eminent importance in cardiovascular research. These topics reflect the major present-day clinical cardiovascular problems: atherosclerosis, hypertension, arrhythmias and heart failure. In addition to these four disease-driven topics, the workshop has sessions on gene expression methodologies and cellular transplant approaches to cardiovascular disease.

Author : Matteo Vatta
Publisher : Frontiers Media SA
Page : 130 pages
File Size : 12,16 MB
Release : 2017-09-12
Category :
ISBN : 2889452816

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The field of cardiovascular genetics has tremendously benefited from the recent application of massive parallel sequencing technology also referred to as next generation sequencing (NGS). However, along with the discovery of additional genes associated with human cardiac diseases, the analysis of large dataset of genetic information uncovered a much more complex and variegated landscape, which often departs from the comfort zone of the monogenic Mendelian diseases image that clinical molecular geneticists have been well acquainted with for many decades. It is now clear that, in addition to highly penetrant genetic variants, which in isolation are able to recapitulate the full clinical presentation when expressed in animal models, we are now aware that a small but significant fraction of subjects presenting with cardiac muscle diseases such as cardiomyopathies or primary arrhythmias such as long QT syndrome (LQTS), may harbor at least two deleterious variants in the same gene (compound heterozygous) or in different gene (double heterozygous). Although the clinical presentation in subjects with more than one deleterious variant appears to be more severe and with an earlier disease onset, it somehow changes the viewpoint of clinical molecular geneticists whose aim is to identify all possible genetic contributors to a human condition. In this light, the employment in clinical diagnostics of the NGS technology, allowing the simultaneous interrogation of a DNA target spanning from large panel of genes up to the entire genome, will definitely aid at uncovering all such contributors, which will have to be tested functionally to confirm their role in human cardiac conditions. The uncovering of all clinically relevant deleterious changes associated with a cardiovascular disease would probably increase our understanding of the clinical variability commonly occurring among affected family relatives, and potentially provide with unexpected therapeutic targets for the treatment of symptoms related to the presence of “accessory” deleterious genetic variants other than the key molecular culprit. The objective of this Research Topic is to explore the current challenges presenting to the cardiovascular genetics providers, such as clinical geneticists, genetic counselors, clinical molecular geneticists and molecular pathologists involved in the diagnosis, counseling, testing and interpretation of genetic tests results for the comprehensive management of patients affected by cardiovascular genetic disorders.

Author : Dan M. Roden
Publisher : John Wiley & Sons
Page : 288 pages
File Size : 21,33 MB
Release : 2009-04-01
Category : Medical
ISBN : 9781444311778

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This comprehensive and concise presentation of genetic factors in cardiovascular disease and their response to therapy consolidates knowledge of this high-interest and emerging topic. Covering broad areas of contemporary genomic medicine and specific cardiovascular diseases, this book is a must for anyone seeking to better understand this rapidly developing field.

Author : Bohuslav Ostadal
Publisher : Springer Science & Business Media
Page : 264 pages
File Size : 25,96 MB
Release : 2011-08-09
Category : Medical
ISBN : 1441972072

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Rapid advances in molecular medicine have led to pronounced new developments in experimental and clinical cardiology. In the embrace of modern molecular biology and bridging the gap between the clinical and the genomic, cardiovascular medicine has seen major strides in the understanding of the molecular mechanisms that drive disease progression. The ability to rapidly identify candidate human genes for cardiovascular diseases lends itself to the development of diverse strategies for disease treatment and management. The wide variety of gene expressions proffers excellent targets for novel therapeutics. Gene therapy is steadily increasing in viability and represents a fascinating arena of research and clinical focus. This book is based on two international Mendel symposia on “Genes and the Heart,” joint meetings of the Japanese and European sections of the International Academy of Cardiovascular Sciences. Highlighting selected symposia contributions, this book explores the role of molecular biology and genetics in the basic knowledge, genesis, and clinical interventions of cardiovascular diseases.

Author : K. Lindpaintner
Publisher : Springer Science & Business Media
Page : 211 pages
File Size : 21,52 MB
Release : 2012-12-06
Category : Science
ISBN : 940090083X

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This book represents a cross-sectional account of the advances that the ability to probe the very roots of biological function have produced in the field of cardiovascular medicine. It arose from a series of articles published over the last few years in the Journal of Hypertension, bringing together an illustrous panel of experts from a broad spectrum of theoretical and applied areas of science.

Author : Dhavendra Kumar
Publisher : Oxford Monographs on Medical G
Page : 853 pages
File Size : 47,65 MB
Release : 2014-10-15
Category : Medical
ISBN : 019989602X

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Preceded by Genomics and clinical medicine / edited by Dhavendra Kumar. [First edition]. 2008.