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"Clifford Jack explores the increasing interest and strategic use of alternatives as a way to help manage volatility amid now-commonplace market swings. He demystifies the alternative asset class, identifies several portfolio strategies, tools and techniques while educating the reader in a colorful way"--Back cover.
"Clifford Jack explores the increasing interest and strategic use of alternatives as a way to help manage volatility amid now-commonplace market swings. He demystifies the alternative asset class, identifies several portfolio strategies, tools and techniques while educating the reader in a colorful way"--Back cover.
A pioneering reference essential in any financial library, the Encyclopedia of Alternative Investments is the most authoritative source on alternative investments for students, researchers, and practitioners in this area. Containing 545 entries, the encyclopedia focuses on hedge funds, managed futures, commodities, and venture capital. It features
In the last decade, great advances have been made in fundamental research and in the applications of bioluminescence and chemiluminescence. These techniques have become vital tools for laboratory analysis. Bioluminescence imaging has emerged as a powerful new optical imaging technique, offering real-time monitoring of spatial and temporal progression of biological processes in living animals. Bioluminescence resonance energy transfer (BRET) methodology has also emerged as a powerful technique for the study of proteinprotein interactions. Luciferase reporter gene technology facilitates monitoring of gene expression and is used to probe molecular mechanisms in the regulation of gene expression. Chemiluminescence detection and analysis have also found diverse applications in life science research; for example, chemiluminescent labels and substrates are now widely used in immunoassay and nucleic acid probe-based assays. The latest advances in this exciting field, from fundamental research to cutting-edge applications, are explored in this most recent volume of the biannual symposium series, the Proceedings of the 15th International Symposium on Bioluminescence and Chemiluminescence. The volume highlights advances in fundamental knowledge of luciferase-based bioluminescence, photoprotein-based bioluminescence, fundamental aspects and applications of chemiluminescence, luminescence imaging, fluorescence quantum dots and other inorganic fluorescent materials, phosphorescence and ultraweak luminescence, and instrumentation for measurement and imaging of luminescence.
This volume discusses the history of alternative rock and the ethos of alt-rockers as rebels who value independence, experimentation, and truth-telling. Rather than making music for broad commercial appeal, these musicians drew from a variety of styles that were considered unfriendly for consumers. Over the years, alternative rock has spawned mash-ups of garage rock, punk, new wave, rap, thrash, and hardcore. This group of indie rockers not only created a new sound but also put forth a different attitude, as they outwardly rejected the musical standards and sales practices set by major record companies.
Extensively revised and updated, Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition reflects the logarithmic progress made in the past four years of oligonucleotide-based therapies, and, in particular, antisense therapeutics and research. Interpreting lessons learned from the clinical trials of first generation drugs, the book evaluates the technology as a whole and offers new directions and avenues of research and development. Divided into five parts, the book begins with a thorough introduction to the mechanism of antisense drug action including the RNase H mechanism, small RNA silencing pathways, and the potential therapeutics of splice switching oligonucleotides. Leading researchers demonstrate the basics of oligonucleotide therapeutics in part two by delineating medicinal chemistry, pharmacokinetics, and delivery routes such as liposomal formulations for nucleic acid delivery. Part three details hybridization based drugs and considers the dramatic advances represented by 2’ methoxyethyl chimeric antisense inhibitors and duplex RNA drugs. Other chemical classes of drugs and mechanisms of action are described in part four with further discussions on improving the second generation antisense drugs. The final part delves deeply into therapeutic applications. Contributing authors examine the potential of antisense drugs for the alleviation of cardiovascular diseases, metabolic diseases, inflammatory diseases, cancer, neurological disorders, and immune modulation. Presenting a highly detailed, lucid discussion of the remarkable advances in the field, Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition provides the platform for researchers to continue to aggressively pursue the great opportunity represented by this exciting technology.
From John Della Volpe, the director of polling at the Harvard Institute of Politics, Fight is an exploration of Gen Z, the issues that matter most to them, and how they will shape the future. 9/11. The war on terror. Hurricane Katrina. The 2008 financial crisis. The housing crisis. The opioid epidemic. Mass school shootings. Global warming. The Trump presidency. COVID-19. Since they were born, Generation Z (also known as "zoomers")—those born from the late 1990s to early 2000s—have been faced with an onslaught of turmoil, destruction and instability unprecedented in modern history. And it shows: they are more stressed, anxious, and depressed than previous generations, a phenomenon John Della Volpe has documented heavily through decades of meeting with groups of young Americans across the country. But Gen Z has not buckled under this tremendous weight. On the contrary, they have organized around issues from gun control to racial and environmental justice to economic equity, becoming more politically engaged than their elders, and showing a unique willingness to disrupt the status quo. In Fight: How Gen Z Is Channeling Their Passion and Fear to Save America, Della Volpe draws on his vast experience to show the largest forces shaping zoomers' lives, the issues they care most about, and how they are—despite older Americans' efforts to label Gen Z as overly sensitive, lazy, and entitled—rising to the unprecedented challenges of their time to take control of their country and our future.
For reasons both financial and environmental, there is a perpetual need to optimize the design and operating conditions of industrial process systems in order to improve their performance, energy efficiency, profitability, safety and reliability. However, with most chemical engineering application problems having many variables with complex inter-relationships, meeting these optimization objectives can be challenging. This is where Multi-Objective Optimization (MOO) is useful to find the optimal trade-offs among two or more conflicting objectives. This book provides an overview of the recent developments and applications of MOO for modeling, design and operation of chemical, petrochemical, pharmaceutical, energy and related processes. It then covers important theoretical and computational developments as well as specific applications such as metabolic reaction networks, chromatographic systems, CO2 emissions targeting for petroleum refining units, ecodesign of chemical processes, ethanol purification and cumene process design. Multi-Objective Optimization in Chemical Engineering: Developments and Applications is an invaluable resource for researchers and graduate students in chemical engineering as well as industrial practitioners and engineers involved in process design, modeling and optimization.