[PDF] Functionalized Silica Nanostructures For Biosensing Applications eBook

Author : Hector Nuño
Publisher :
Page : 144 pages
File Size : 44,87 MB
Release : 2010
Category : Biosensors
ISBN :

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This work covers both two dimensional (2D) and three dimensional (3D) silica-based nanostructures for use in biomedical sensing applications. The first section of this study discusses the formation of 2D nanostructured surface plasmon resonance (SPR)-based biosensor substrates. The surface of these biosensors was nanostructured by adding sacrificial star polymers or block copolymers to a silicate precursor solution. Subsequent vitrification resulted in two distinct morphological patterns: random and ordered porosity. Amino groups on the surface of the biosensors enabled the installation of analyte receptors and antifouling agents such as oligo (ethylene oxide). The second section discusses the development of 3D core-shell silica nanoparticles (SNPs). For this work, star polymers were generated to provide hydrophobic interiors capable of sequestering large hydrophobic porphyrinoid dyes and hydrophilic exteriors capable of templating the growth of silica shells. The diameter of the SNPs (25-100 nm) varied depending on reaction time, template size, and reagent concentration. The shell thickness was also controlled in order to either release or retain the hydrophobic dyes. The SNPs were surface-functionalized with biocompatible "stealth" materials such as poly (ethylene oxide) to generate non-toxic, water-soluble nanoparticles for the in vivo delivery of various hydrophobic imaging and therapeutic materials.

Author : Yupeng Shi
Publisher :
Page : 0 pages
File Size : 11,99 MB
Release : 2018
Category :
ISBN :

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Silica nanoparticles, thanks to the great easy and adaptability of particle synthesis and limited biotoxicity, is very widely studied for biomedical applications. This thesis conducted a large diversity of investigations involving silica nanomaterials. Firstly, the physicochemical properties and biodegradation properties of three types of structured silica nanoparticles were studied in a buffer, a culture medium and in contact with human dermal fibroblasts that suggest that, under these conditions, the silica nanoparticles must be mainly considered as degraded by hydrolysis and not biodegraded. Then, multifunctional silica nanoparticles which are consist of hollow silica nanoparticles and MnO2 nanosheets were synthesized. And the control drug release and imaging performance of this nanoplatforms were studied from 2D to 3D models. This approach could be used for a rapid assessment of the biofunctionality of nanoparticles before setting up in vivo experiments. Furthermore, a new 3D collagen-based nanocomposites using silica rods were studied and the relationships between the composite composition, structure and mechanical properties, emphasizing the key role of collagen-silica interactions. The influence of these parameters on the adhesion and proliferation of fibroblast cells was also investigated. In addition, we prepared and used magnetic silica nanorods to control particle orientation within the collagen network thanks to an external magnetic field. All the results bring new insights on the preparation and properties of bionanocomposites and open the route to multifunctional hydrogels.

Author : Sachin Namdeo Kothawade
Publisher :
Page : 0 pages
File Size : 16,12 MB
Release : 2024-11-20
Category : Medical
ISBN : 9783111338446

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Mesoporous silica comprehensively covers the importance and applications of mesoporous silica nanoparticles in the field of nanoscience and nanotechnology. The book delves into the synthesis and characterization of mesoporous silica nanoparticles, discussing various synthesis methods and characterization techniques employed in their production. It explores the properties and structure of mesoporous silica nanoparticles, including their porosity, surface area, structural features, and tunability. It discusses mechanical, thermal, and optical properties. The applications of mesoporous silica nanoparticles in drug delivery are covered in detail, focusing on controlled release systems, targeted drug delivery, and theranostic applications.The catalytic applications of mesoporous silica nanoparticles are examined, including the use of these nanoparticles as supported catalysts in catalytic reactions, with discussions on reaction mechanisms. The book also explores the sensing and biosensing applications of mesoporous silica nanoparticles, including optical and electrochemical sensing, bioanalytical applications, and detection of biomolecules and environmental pollutants. Surface functionalization techniques for mesoporous silica nanoparticles are discussed, highlighting the importance of tailoring their properties for specific applications. Biocompatibility and toxicity considerations are addressed, providing insights into the assessment of biocompatibility, toxicity evaluation, mitigation strategies, and regulatory considerations. The future directions and emerging trends in mesoporous silica nanoparticle research are explored, along with interdisciplinary approaches, challenges, and opportunities in the field. The book concludes by summarizing the key findings and discussing the overall significance of mesoporous silica nanoparticles in nanoscience and nanotechnology. The references section provides a comprehensive list of sources used throughout the book for further exploration. The book serves as an essential resource for researchers, professionals, and students interested in understanding the synthesis, characterization, properties, and diverse applications of mesoporous silica nanoparticles in the realm of nanoscience and nanotechnology.

Author : Jayeeta Chattopadhyay
Publisher : CRC Press
Page : 175 pages
File Size : 33,53 MB
Release : 2021-07-22
Category : Science
ISBN : 1000425274

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Recent advances in nanotechnology has led the nanomaterials into the realm of sensing applications. This descriptive book utilizes a multi-disciplinary approach to provide extensive information about sensors and elucidates the impact of nanotechnology on development of chemical and biosensors for diversified applications. The main focus of this book is not only the inclusion of various research works, which have already been reported in literature, but also to make a potential conclusion about the mechanism behind this. This book will serve as an invaluable tool for both frontline researchers and academicians to work towards the future development of nanotechnology in sensing devices.

Author :
Publisher : Academic Press
Page : 185 pages
File Size : 40,25 MB
Release : 2018-10-22
Category : Science
ISBN : 0128155205

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Cancer Therapy and Diagnosis, Part B, Volume 44 in The Enzymes series highlights new advances in the field, with this new volume presenting interesting chapters on Mesoporous silica nanoparticle synthesis, Periodic mesoporous organosilica, Nanovalves and other nanomachine-equipped nanoparticles and controlled release, Two-photon light control and photodynamic therapy, Biodegradable PMO nanoparticles, Cationic mesoporous silica and protein delivery, Drug loading, stimuli-responsive delivery and cancer treatment, Animal models and cancer therapy, siRNA delivery and TWIST shutdown for ovarian cancer treatment, and TBC (mesoporous silica nanoparticles and cancer therapy or biodistribution of MSN). Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in The Enzymes series Updated release includes the latest information on Cancer Therapy and Diagnosis