[PDF] Fluorous Chemistry eBook

Author : István T. Horváth
Publisher : Springer Science & Business Media
Page : 418 pages
File Size : 48,88 MB
Release : 2011-11-04
Category : Science
ISBN : 3642252338

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Structural, Physical, and Chemical Properties of Fluorous Compounds, by J.A. Gladysz Selective Fluoroalkylation of Organic Compounds by Tackling the “Negative Fluorine Effect”, by W. Zhang, C. Ni and J. Hu Synthetic and Biological Applications of Fluorous Reagents as Phase Tags, by S. Fustero, J. L. Aceña and S. Catalán Chemical Applications of Fluorous Reagents and Scavengers, by Marvin S. Yu Fluorous Methods for the Synthesis of Peptides and Oligonucleotides, by B. Miriyala Fluorous Organic Hybrid Solvents for Non-Fluorous Organic Synthesis, by I. Ryu Fluorous Catalysis: From the Origin to Recent Advances, by J.-M. Vincent Fluorous Organocatalysis, by W. Zhang Thiourea Based Fluorous Organocatalyst, by C. Cai Fluoroponytailed Crown Ethers and Quaternary Ammonium Salts as Solid–Liquid Phase Transfer Catalysts in Organic Synthesis, by G. Pozzi and R. H. Fish Fluorous Hydrogenation, by X. Zhao, D. He, L. T. Mika and I. T. Horváth Fluorous Hydrosilylation, by M. Carreira and M. Contel Fluorous Hydroformylation, by X. Zhao, D. He, L.T. Mika and I. Horvath Incorporation of Fluorous Glycosides to Cell Membrane and Saccharide Chain Elongation by Cellular Enzymes, by K. Hatanaka Teflon AF Materials, by H. Zhang and S. G. Weber Ecotoxicology of Organofluorous Compounds, by M. B. Murphy, E. I. H. Loi, K. Y. Kwok and P. K. S. Lam Biology of Fluoro-Organic Compounds, by X.-J. Zhang, T.-B. Lai and R. Y.-C. Kong

Author : John A. Gladysz
Publisher : John Wiley & Sons
Page : 624 pages
File Size : 23,2 MB
Release : 2006-03-06
Category : Science
ISBN : 3527604499

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Edited by the leading experts John Gladysz, Dennis Curran, and István Horváth, this handbook is the first to summarize all the essential aspects of this emerging field of chemistry. Whether the reader is seeking an introduction to the concept of fluorous biphase catalysis, summaries of partition coefficients involving fluorous and organic solvents, or information on the latest fluorous mixture separation techniques, this authoritative compilation of contributions, written by the world's top authors, provides key information needed for successfully working with the diverse and fascinating families of fluorous molecules. The large number of reliable experimental procedures in particular makes this the ideal guide for newcomers wanting to use this elegant method in the laboratory. In addition, experts will also find a wealth of important information concisely contained in one ready reference. The result is an indispensable resource for everyone currently working or intending to work in this field.

Author : István T. Horváth
Publisher : Springer
Page : 418 pages
File Size : 50,86 MB
Release : 2011-11-03
Category : Science
ISBN : 3642252346

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Structural, Physical, and Chemical Properties of Fluorous Compounds, by J.A. Gladysz Selective Fluoroalkylation of Organic Compounds by Tackling the “Negative Fluorine Effect”, by W. Zhang, C. Ni and J. Hu Synthetic and Biological Applications of Fluorous Reagents as Phase Tags, by S. Fustero, J. L. Aceña and S. Catalán Chemical Applications of Fluorous Reagents and Scavengers, by Marvin S. Yu Fluorous Methods for the Synthesis of Peptides and Oligonucleotides, by B. Miriyala Fluorous Organic Hybrid Solvents for Non-Fluorous Organic Synthesis, by I. Ryu Fluorous Catalysis: From the Origin to Recent Advances, by J.-M. Vincent Fluorous Organocatalysis, by W. Zhang Thiourea Based Fluorous Organocatalyst, by C. Cai Fluoroponytailed Crown Ethers and Quaternary Ammonium Salts as Solid–Liquid Phase Transfer Catalysts in Organic Synthesis, by G. Pozzi and R. H. Fish Fluorous Hydrogenation, by X. Zhao, D. He, L. T. Mika and I. T. Horváth Fluorous Hydrosilylation, by M. Carreira and M. Contel Fluorous Hydroformylation, by X. Zhao, D. He, L.T. Mika and I. Horvath Incorporation of Fluorous Glycosides to Cell Membrane and Saccharide Chain Elongation by Cellular Enzymes, by K. Hatanaka Teflon AF Materials, by H. Zhang and S. G. Weber Ecotoxicology of Organofluorous Compounds, by M. B. Murphy, E. I. H. Loi, K. Y. Kwok and P. K. S. Lam Biology of Fluoro-Organic Compounds, by X.-J. Zhang, T.-B. Lai and R. Y.-C. Kong

Author : Peer Kirsch
Publisher : John Wiley & Sons
Page : 320 pages
File Size : 49,28 MB
Release : 2006-03-06
Category : Science
ISBN : 3527604197

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In this handbook, Peer Kirsch clearly shows that this exciting field is no longer an exotic area of research. Aimed primarily at synthetic chemists wanting to gain a deeper understanding of the fascinating implications of including the highly unusual element fluorine in organic compounds, the main part of the book presents a wide range of synthetic methodologies and the experimental procedures selected undeniably show that this can be done with standard laboratory equipment. To round off, the author looks at fluorous chemistry and the applications of organofluorine compounds in liquid crystals, polymers and more besides. This long-awaited book represents an indispensable source of high quality information for everyone working in the field.

Author : Thomas Braun
Publisher : Springer
Page : 247 pages
File Size : 19,5 MB
Release : 2015-08-05
Category : Science
ISBN : 3319220969

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The series Topics in Organometallic Chemistry presents critical overviews of research results in organometallic chemistry. As our understanding of organometallic structure, properties and mechanisms increases, new ways are opened for the design of organometallic compounds and reactions tailored to the needs of such diverse areas as organic synthesis, medical research, biology and materials science. Thus the scope of coverage includes a broad range of topics in pure and applied organometallic chemistry, where new breakthroughs are being achieved that are of significance to a larger scientific audience. The individual volumes of Topics in Organometallic Chemistry are thematic. Review articles are generally invited by the volume editors.

Author : Axel Haupt
Publisher : Walter de Gruyter GmbH & Co KG
Page : 642 pages
File Size : 50,55 MB
Release : 2021-03-22
Category : Science
ISBN : 3110659336

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This textbook provides a comprehensive overview of synthesis protocols for organic and inorganic fluorinated compounds. Electrochemical fluorination, nucleophilic, radical and electrophilic addition is discussed. Applications of organofluorine compounds, main group fluorides and metal fluorides in pharmaceuticals, electronic devices and medical diagnostics is covered. Each chapter will be followed by exercises covering the topics.

Author : Jean-Philippe Goddard
Publisher : John Wiley & Sons
Page : 162 pages
File Size : 18,90 MB
Release : 2020-01-09
Category : Science
ISBN : 111969504X

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Biphasic Chemistry and The Solvent Case examines recent improvements in reaction conditions, in order to affirm the role of chemistry in the sustainable field. This book shows that those who work within the chemistry industry support limits for the use of toxic or flammable solvents, since it reduces the purifications to simple filtrations. Thanks to commercial scavengers, solid phase syntheses are now available to all. Fluorine biphasic catalysis enables extremely efficient catalyst recycling and has a high applicability potential at the industrial level. This book also reviews the many studies that have shown that water is a solvent of choice for most synthetic reactions. Particular traits can be obtained and the effects on thermodynamics make it possible to operate at lower temperatures, thereby achieving energy savings. Finally the great diversity of application of the reactions without solvents is illustrated.

Author : Sanjay K. Sharma
Publisher : CRC Press
Page : 450 pages
File Size : 39,23 MB
Release : 2010-07-19
Category : Nature
ISBN : 1439824746

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When the Nobel Prize Committee recognized the importance of green chemistry with its 2005 Nobel Prize for Chemistry, this relatively new science came into its own. Although no concerted agreement has been reached yet about the exact content and limits of this interdisciplinary discipline, there seems to be increasing interest in environmental topic

Author : Iwao Ojima
Publisher : John Wiley & Sons
Page : 640 pages
File Size : 32,59 MB
Release : 2009-03-23
Category : Science
ISBN : 9780470744086

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The extraordinary potential of fluorine-containing molecules in medicinal chemistry and chemical biology has been recognized by researchers outside of the traditional fluorine chemistry field, and thus a new wave of fluorine chemistry is rapidly expanding its biomedical frontiers. With several of the best selling drugs in the world crucially containing fluorine atoms, the incorporation of fluorine to drug leads has become an essential practice in biomedical research, especially for drug design and discovery as well as development. Focusing on the unique and significant roles that fluorine plays in medicinal chemistry and chemical biology, this book reviews recent advances and future prospects in this rapidly developing field. Topics covered include: Discovery and development of fluorine containing drugs and drug candidates. New and efficient synthetic methods for medicinal chemistry and the optimisation of fluorine-containing drug candidates. Structural and chemical biology of fluorinated amino acids and peptides. Fluorine labels as probes in metabolic study, protein engineering and clinical diagnosis. Applications of 19F NMR spectroscopy in biomedical research. An appendix presents an invaluable index of all fluorine-containing drugs that have been approved by the US Food and Drug Administration, including information on structure and pharmaceutical action. Fluorine in Medicinal Chemistry and Chemical Biology will serve as an excellent reference source for graduate students as well as academic and industrial researchers who want to take advantage of fluorine in biomedical research.