[PDF] Fabrication Of Multi Component Hydrogel Microstructures And Microdevices eBook

Author : Aaron T. Ohta
Publisher : MDPI
Page : 179 pages
File Size : 22,29 MB
Release : 2018-07-03
Category : Science
ISBN : 3038426180

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This book is a printed edition of the Special Issue "Microdevices and Microsystems for Cell Manipulation" that was published in Micromachines

Author : Allison Paige Myers
Publisher :
Page : 304 pages
File Size : 37,20 MB
Release : 2018
Category :
ISBN :

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Sociomicrobiology has recently come to the forefront of bioanalytical research, primarily due to its physiological impact in the medical field. The interaction of bacterial cells in small, dense populations can reveal emergent properties of microbial communities, such as increased virulence and pathogenicity, as well as create a more accurate model for bacterial behavior in natural environments. Such systems are particularly relevant in mono- and polymicrobial communities, which exhibit social behaviors as well as the potential for symbiotic and/or adversarial interactions between species. The standard techniques for culturing bacteria lack the tools to provide adequate control over polymicrobial organization on a microscopic scale or to evaluate the spatiotemporal dynamics of bacterial interactions. Using our previously developed micro-3D printing platform, we can arrange cells in biocompatible, pico-liter sized containers, allowing us to overcome these prior spatial limitations. However, key questions still exist regarding the dynamics of interactions between distinct cellular populations. This dissertation focuses on the development of a modified micro-3D printing platform that enables us to fabricate protein-based structures around bacteria on the tip of a moveable substrate. Fabricating structures on moveable substrates such as a glass rod or optical fiber allows us to precisely tune where bacterial clusters are located in relation to varying stimuli and enables delivery of fabricated structures to remote environments such as chronic wounds. However, several challenges were faced in the development of this technique, such as optimization of fabrication solutions, successful layering of hydrogels of varying composition on glass rods, and creation of a custom-built fabrication setup for fabrication on optical fiber tips. Development of these techniques enables us to better appreciate the intricacies of sociomicrobial behavior and interactions, allowing for a better understanding of microbial responses leading to antibiotic resistance, and directing a better approach towards the treatment of various microbial infections

Author : Sunpreet Singh
Publisher : Elsevier
Page : 277 pages
File Size : 47,49 MB
Release : 2021-04-06
Category : Technology & Engineering
ISBN : 0128236167

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Approx.264 pages Approx.264 pages

Author : Xiangchun Xuan
Publisher : MDPI
Page : 228 pages
File Size : 50,36 MB
Release : 2021-02-24
Category : Science
ISBN : 3036500480

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Micro/nanofluidics-based lab-on-a-chip devices have found extensive applications in the analysis of chemical and biological samples over the past two decades. Electrokinetics is the method of choice in these micro/nano-chips for transporting, manipulating, and sensing various analyte species (e.g., ions, molecules, fluids, and particles). This book aims to highlight the recent developments in the field of micro/nano-chip electrokinetics, ranging from the fundamentals of electrokinetics to the applications of electrokinetics to both chemo- and bio-sample handling.

Author : George K. Knopf
Publisher : CRC Press
Page : 666 pages
File Size : 38,38 MB
Release : 2017-12-19
Category : Technology & Engineering
ISBN : 1351833510

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In Optical Nano and Micro Actuator Technology, leading engineers, material scientists, chemists, physicists, laser scientists, and manufacturing specialists offer an in-depth, wide-ranging look at the fundamental and unique characteristics of light-driven optical actuators. They discuss how light can initiate physical movement and control a variety of mechanisms that perform mechanical work at the micro- and nanoscale. The book begins with the scientific background necessary for understanding light-driven systems, discussing the nature of light and the interaction between light and NEMS/MEMS devices. It then covers innovative optical actuator technologies that have been developed for many applications. The book examines photoresponsive materials that enable the design of optically driven structures and mechanisms and describes specific light-driven technologies that permit the manipulation of micro- and nanoscale objects. It also explores applications in optofluidics, bioMEMS and biophotonics, medical device design, and micromachine control. Inspiring the next generation of scientists and engineers to advance light-driven technologies, this book gives readers a solid grounding in this emerging interdisciplinary area. It thoroughly explains the scientific language and fundamental principles, provides a holistic view of optical nano and micro actuator systems, and illustrates current and potential applications of light-driven systems.

Author : Michael Balls
Publisher : Springer Science & Business Media
Page : 282 pages
File Size : 40,51 MB
Release : 2012-03-22
Category : Medical
ISBN : 1461430550

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The central theme running through this volume on New Technologies for Toxicity Testing is the development and application of advanced techniques for cell and tissue culture, as well as new markers and endpoints of toxicity, as alternatives to the traditional paradigm of relying on data from laboratory animal tests to undertake labelling and risk assessment. Of course, many of the techniques and methods described in this volume are in the early stages of development, and much work will be needed to ensure their further improvement, optimisation and validation. However, we are confident that this will be achieved and that, just as with the in vitro assays that were validated and granted regulatory acceptance over the last decade, these, and many other new, advanced methods, will likewise become part of the toxicologist’s improved toolbox for coping with increasingly stringent and numerous regulatory requirements and test chemicals, while placing less reliance on traditional testing paradigms.

Author : Ashutosh Tiwari
Publisher : John Wiley & Sons
Page : 421 pages
File Size : 43,68 MB
Release : 2014-05-09
Category : Technology & Engineering
ISBN : 1118773683

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Offers a comprehensive and interdisciplinary view of cutting-edge research on advanced materials for healthcare technology and applications Advanced healthcare materials are attracting strong interest in fundamental as well as applied medical science and technology. This book summarizes the current state of knowledge in the field of advanced materials for functional therapeutics, point-of-care diagnostics, translational materials, and up-and-coming bioengineering devices. Advanced Healthcare Materials highlights the key features that enable the design of stimuli-responsive smart nanoparticles, novel biomaterials, and nano/micro devices for either diagnosis or therapy, or both, called theranostics. It also presents the latest advancements in healthcare materials and medical technology. The senior researchers from global knowledge centers have written topics including: State-of-the-art of biomaterials for human health Micro- and nanoparticles and their application in biosensors The role of immunoassays Stimuli-responsive smart nanoparticles Diagnosis and treatment of cancer Advanced materials for biomedical application and drug delivery Nanoparticles for diagnosis and/or treatment of Alzheimers disease Hierarchical modelling of elastic behavior of human dental tissue Biodegradable porous hydrogels Hydrogels in tissue engineering, drug delivery, and wound care Modified natural zeolites Supramolecular hydrogels based on cyclodextrin poly(pseudo)rotaxane Polyhydroxyalkanoate-based biomaterials Biomimetic molecularly imprinted polymers