[PDF] Experimental Glycoscience eBook

Author : Naoyuki Taniguchi
Publisher : Springer Science & Business Media
Page : 476 pages
File Size : 31,66 MB
Release : 2009-03-05
Category : Science
ISBN : 4431779221

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The aim of this book is to provide experimental protocols covering many aspects of glycobiology, glycotechnology, and chemistry: biochemistry, molecular and cellular biology, genetics, physiology, and medicine. The protocols are all self-contained descriptions of the equipment and reagents needed, followed by details of the experimental procedure. In the post-genomic era, glycobiology is coming of age because more than half of proteins are glycosylated and the importance of sugar chains in various fields of life science research cannot be disregarded. Many scientists had not entered this area because glycobiology and glycoscience used to be considered difficult fields. This book, therefore, is presented much like a cookbook which can help scientists in fields other than glycobiology and glycoscience carry out research more easily.

Author : National Research Council
Publisher : National Academies Press
Page : 171 pages
File Size : 27,81 MB
Release : 2012-10-23
Category : Science
ISBN : 0309260868

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A new focus on glycoscience, a field that explores the structures and functions of sugars, promises great advances in areas as diverse as medicine, energy generation, and materials science, this report finds. Glycans-also known as carbohydrates, saccharides, or simply as sugars-play central roles in many biological processes and have properties useful in an array of applications. However, glycans have received little attention from the research community due to a lack of tools to probe their often complex structures and properties. Transforming Glycoscience: A Roadmap for the Future presents a roadmap for transforming glycoscience from a field dominated by specialists to a widely studied and integrated discipline, which could lead to a more complete understanding of glycans and help solve key challenges in diverse fields.

Author : Tamao Endo
Publisher : Springer
Page : pages
File Size : 19,57 MB
Release : 2021-01-14
Category : Science
ISBN : 9784431548362

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The aim of the book is to provide a succinct overview of the current status of glycoscience from both basic biological and medical points of view and to propose future directions, in order to facilitate further integrations of glycoscience with other fields in biological and medical studies. Glycans (carbohydrate oligomers) are the so-called “building blocks” of carbohydrates, nucleic acids, proteins and lipids and play major roles in many biological phenomena as well as in various pathophysiological processes. However, this area of glycoscience has been neglected from the research community because glycan structures are very complex and functionally diverse and as compared to proteins and nucleic acids simple tools for the amplification, sequencing and auto-synthesis of glycans are not available. Many scientists in other fields of research have now realized that glycosylation, i.e. the addition of glycans to a protein backbone, is the most abundant post translational modification reactions and is an important field of research and sometimes they require a glycobiology and/or glycochemistry approach to be used. It is still difficult, however, for non-expert researchers to use these techniques. This book will provide numerous but simple overviews of current topics and protocols for the experiments. The book is aimed at university students and above, including non-experts in the field of glycoscience.

Author : Naoyuki Taniguchi
Publisher : Springer
Page : 252 pages
File Size : 20,77 MB
Release : 2008-08-06
Category : Science
ISBN : 9784431779230

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The aim of this book is to provide experimental protocols covering many aspects of glycobiology, glycotechnology, and chemistry: biochemistry, molecular and cellular biology, genetics, physiology, and medicine. The protocols are all self-contained descriptions of the equipment and reagents needed, followed by details of the experimental procedure. In the post-genomic era, glycobiology is coming of age because more than half of proteins are glycosylated and the importance of sugar chains in various fields of life science research cannot be disregarded. Many scientists had not entered this area because glycobiology and glycoscience used to be considered difficult fields. This book, therefore, is presented much like a cookbook which can help scientists in fields other than glycobiology and glycoscience carry out research more easily.

Author :
Publisher : Elsevier
Page : 3458 pages
File Size : 32,46 MB
Release : 2021-08-09
Category : Science
ISBN : 9780128194751

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Comprehensive Glycoscience, Second Edition covers the most elementary of topics and progresses to the most current and advanced research in the field. This allows for readers to quickly and easily find the appropriate glycoscience information for their research. It assembles the top minds in this area and provide an update to the renowned 2007 first edition, including new discoveries and latest advances in glycoscience-related research areas such as glycan microarrays, carbohydrate materials, glycoengineering and microbiome research. The result is an up-to-date work which will impress readers with the many new advances that are outlined and taught in this second edition. Most areas of the original edition have been majorly updated, some overlapping topics have been consolidated, and several topics have been rearranged into more appropriate sections. Combines multiple aspects of glycoscience in one comprehensive and reliable reference work Includes all major developments since 2007 (e.g. nanotechnology) This new edition places glycoscience at the crossroads of several disciplines such as biology, biochemistry, glycobiology and synthetic chemistry offering a truly interdisciplinary perspective

Author : Thomas Lütteke
Publisher : Humana
Page : 0 pages
File Size : 10,17 MB
Release : 2016-10-05
Category : Science
ISBN : 9781493941957

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This book provides current glycoinformatics methods and protocols used to support the determination of carbohydrate structures in biological samples as well as carbohydrate structure databases, the interaction of carbohydrates with proteins, and theoretical and experimental methods to study their three-dimensional structure and dynamics. Glycoinformatics explores this recently emerged field, which has come into being in order to address the needs of encoding, storing, and analyzing carbohydrate ‘sequences’ and their taxonomy using computers. Written in the highly successful Methods in Molecular Biology series format, chapters contain the kind of detailed description and key implementation advice to ensure successful results. Authoritative and timely, Glycoinformatics demonstrates the progress that has been achieved in glycoinformatics, which indicates that it is no longer a niche subject covered by only a few scientists but is truly coming of age.

Author : Gordan Lauc
Publisher : Springer Nature
Page : 392 pages
File Size : 31,22 MB
Release : 2021-09-08
Category : Science
ISBN : 3030701158

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Glycobiology is an emerging field of studying glycans (sugars) and glycoconjugates that are essentially involved in almost all biological processes, from fine-tuning glycoprotein function to protein-protein interactions, signaling, immune response, host-pathogen interactions, etc. However, due to structural complexity of glycans and analytical challenges this exciting field was lagging behind other areas of biology. With technological advancements growing number of glycans’ functions are being discovered and the study of glycans is becoming a cutting-edge discipline in basic and clinical research. Despite recent developments in glycobiology field, many aspects of glycosylation process still remain unknown, both in a healthy human organism and in pathological states. Human glycome is dynamic and changes with physiological triggers, immune challenges and disease. Atypical glycosylation is consequently a subject of disease biomarker research, and a target for therapeutic interventions. On the other hand, properties of glycosylated biotherapeutics are predominantly determined by their glycans. The Role of Glycosylation in Health and Disease provides a comprehensive overview of types and functions of glycans in a healthy human organism as well as their role in pathophysiology of different diseases and efficiency of glycosylated biotherapeutics. Written by the experts in the field, this book aims to bring glycobiology field closer to students, researchers in life sciences and professionals in biopharmaceutical industry.

Author : Ajit Varki
Publisher : CSHL Press
Page : 694 pages
File Size : 28,96 MB
Release : 1999
Category : Medical
ISBN : 9780879696818

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Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

Author : J. C. Spencer
Publisher : Createspace Independent Publishing Platform
Page : 324 pages
File Size : 13,59 MB
Release : 2017-08-10
Category :
ISBN : 9781974038862

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Glycoscience 101 is a collection of over 101 lessons by JC Spencer that explains how Glycoscience will be brought to the people and why Glycoscience is the future of medicine and healthcare. Glycoscience 101 is not as much of a scholarly study of what is Glycoscience as it is an inside look at the importance of the science and how Glycoscience is more beneficial to human civilization than man has ever known. Glycoscience, as presented here, is the study of applied biology and chemistry that deals with the structure function of specific carbohydrates which the author describes as Smart Sugars. Glycoscience 101 conveys an understanding of how Glycoscience impacts all plants, animals, and humans and will change the way we live.

Author : Elizabeth Yuriev
Publisher : CRC Press
Page : 351 pages
File Size : 38,1 MB
Release : 2012-09-27
Category : Medical
ISBN : 1439854602

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Structural Glycobiology covers the experimental, theoretical, and alternative technologies used in the study of the structural basis for the diverse biological roles of carbohydrates. The book overviews the application of specialized technologies to the study of carbohydrates in biology, reviews relevant and current research in the field, and is illustrated throughout by specific examples of how research investigations have yielded key structural and associated biological data on carbohydrates and glycolipids. In particular, the book focuses on: X-ray crystallography and small-angle scattering, NMR, and cryo-electron microscopy techniques Theoretical (modeling-based) approaches, such as molecular mechanics, molecular dynamics, free energy calculations, and carbohydrate docking Alternative techniques for yielding structural information on carbohydrates from complex biological samples Carbohydrates in medicine, specifically in areas that have been directly impacted by our understanding of the structural role of carbohydrates in immune recognition: cancer, organ transplantation, and infection