[PDF] Experimental Design For Formulation eBook

Author : Wendell F. Smith
Publisher : SIAM
Page : 386 pages
File Size : 28,8 MB
Release : 2005-01-01
Category : Science
ISBN : 9780898718393

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Many products, such as foods, personal-care products, beverages, and cleaning agents, are made by mixing ingredients together. This book describes a systematic methodology for formulating such products so that they perform according to one's goals, providing scientists and engineers with a fast track to the implementation of the methodology. Experimental Design for Formulation contains examples from a wide variety of fields and includes a discussion of how to design experiments for a mixture setting and how to fit and interpret models in a mixture setting. It also introduces process variables, the combining of mixture and nonmixture variables in a designed experiment, and the concept of collinearity and the possible problems that can result from its presence. Experimental Design for Formulation is a useful manual for the formulator and can also be used by a resident statistician to teach an in-house short course. Statistical proofs are largely absent, and the formulas that are presented are included to explain how the various software packages carry out the analysis. Many examples are given of output from statistical software packages, and the proper interpretation of computer output is emphasized. Other topics presented include a discussion of an effect in a mixture setting, the presentation of elementary optimization methods, and multiple-response optimization wherein one seeks to optimize more than one response.

Author : Gareth A. Lewis
Publisher : CRC Press
Page : 512 pages
File Size : 34,41 MB
Release : 1998-09-10
Category : Mathematics
ISBN : 0824746880

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This useful reference describes the statistical planning and design of pharmaceutical experiments, covering all stages in the development process-including preformulation, formulation, process study and optimization, scale-up, and robust process and formulation development.Shows how to overcome pharmaceutical, technological, and economic constraint

Author : Wendell F. Smith
Publisher : SIAM
Page : 372 pages
File Size : 36,46 MB
Release : 2005-04-01
Category : Science
ISBN : 0898715806

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Gender-Structured Population Modeling: Mathematical Methods, Numerics, and Simulations gives a unified presentation of and mathematical framework for modeling population growth by couple formation.

Author : Sarwar Beg
Publisher : Springer Nature
Page : 99 pages
File Size : 45,3 MB
Release : 2021-01-12
Category : Medical
ISBN : 9813347171

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This book volume provides complete and updated information on the applications of Design of Experiments (DoE) and related multivariate techniques at various stages of pharmaceutical product development. It discusses the applications of experimental designs that shall include oral, topical, transdermal, injectables preparations, and beyond for nanopharmaceutical product development, leading to dedicated case studies on various pharmaceutical experiments through illustrations, art-works, tables and figures. This book is a valuable guide for all academic and industrial researchers, pharmaceutical and biomedical scientists, undergraduate and postgraduate research scholars, pharmacists, biostatisticians, biotechnologists, formulations and process engineers, regulatory affairs and quality assurance personnel.

Author : Sarwar Beg
Publisher :
Page : 0 pages
File Size : 27,30 MB
Release : 2021
Category :
ISBN : 9789813343528

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This book volume provides complete and updated information on the applications of Design of Experiments (DoE) and related multivariate techniques at various stages of pharmaceutical product development. It discusses the applications of experimental designs that shall include oral, topical, transdermal, injectables preparations, and beyond for nanopharmaceutical product development, leading to dedicated case studies on various pharmaceutical experiments through illustrations, art-works, tables and figures. This book is a valuable guide for all academic and industrial researchers, pharmaceutical and biomedical scientists, undergraduate and postgraduate research scholars, pharmacists, biostatisticians, biotechnologists, formulations and process engineers, regulatory affairs and quality assurance personnel. .

Author : Mark J. Anderson
Publisher : Taylor & Francis
Page : 190 pages
File Size : 23,19 MB
Release : 2018-04-17
Category : Business & Economics
ISBN : 1351677527

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Many chemists – especially those most brilliant in their field – fail to appreciate the power of planned experimentation. They dislike the mathematical aspects of statistical analysis. In addition, these otherwise very capable chemists also dismissed predictive models based only on empirical data. Ironically, in the hands of subject matter experts like these elite chemists, the statistical methods of mixture design and analysis provide the means for rapidly converging on optimal compositions. What differentiates Formulation Simplified from the standard statistical texts on mixture design is that the authors make the topic relatively easy and fun to read. They provide a whole new collection of insighful original studies that illustrate the essentials of mixture design and analysis. Solid industrial examples are offered as problems at the end of many chapters for those who are serious about trying new tools on their own. Statistical software to do the computations can be freely accessed via a web site developed in support of this book.

Author : N. Anthony Armstrong
Publisher : Taylor & Francis Group
Page : 188 pages
File Size : 44,40 MB
Release : 1990
Category : Medical
ISBN :

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Addresses experimental and optimization techniques in the context of pharmaceutical research, formulation and manufacture. Specific techniques are described, showing concepts, benefits and limitations. The book includes clinical and consumer trials from a spectrum of pharmaceutical sciences.

Author : N. Anthony Armstrong
Publisher : CRC Press
Page : 256 pages
File Size : 40,1 MB
Release : 2006-01-20
Category : Medical
ISBN : 9780415299015

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Completely revised and updated, Pharmaceutical Experimental Design and Interpretation, Second Edition explains the major methods of experimental design and evaluation such as multivariate, sequential, and principal components analysis. With new sections on neural networks, artificial intelligence, fractional designs, and optimization techniques, this source will prove invaluable to anyone involved in the design and execution of pharmaceutical research studies and the interpretation of study data.

Author : Vladimir I. Razinkov
Publisher : Academic Press
Page : 230 pages
File Size : 49,64 MB
Release : 2021-11-03
Category : Medical
ISBN : 0128173491

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Computational and Experimental Design of Biopharmaceutical Formulations outlines available experimental and computational tools. It describes a rational approach to formulation design not limited by experimental design that extends to modern methods of computational modeling. These methods include the modeling of protein structure and dynamics, and of solution properties in the presence of proteins and excipients. The chapters in this book consider computational modeling of protein-solution interactions, the design of early-stage formulation studies, the design of late-stage formulation studies, automation, high-throughput and control, design of lyophilized formulations, and emerging technologies in the future formulation development. Reviews methods for the design of biopharmaceutical formulations Considers both experimental and computational methods in concert Details design techniques specific to each step in protein formulation development Discusses the predictive power of methods used in formulation stability studies Describes and considers the potential of emerging models and experimental technologies