[PDF] Enhancement Of Sas And R For Meta Analysis Of Observational Studies eBook

Author : Deedra Rae Nicolet
Publisher :
Page : 138 pages
File Size : 24,42 MB
Release : 2006
Category : Meta-analysis
ISBN :

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Abstract: Meta-analysis is used to get an overall effect estimate from a collection of previously conducted studies on the same subject. When this method first became popular, it was in the setting of clinical trials. Meta-analysis identifies homogeneity of effect estimates between studies. This type of analysis also takes into consideration confounding factors and decreases their effect on the estimate. Meta-analysis consists of searching the literature for relevant studies, deciding which studies to include in the analysis, extracting relevant information and analyzing the data. The goal of meta-analysis is to estimate the effect estimate from a collection of relevant studies. In order to find this estimate, we consider two possible models for the data. The data could be fit using a fixed-effects or random-effects model. The fixed- effects model has two popular methods of finding the estimate that we will consider here, the Mantel-Haenszel method and the confidence interval method. This model is based on the assumption that there is only a within study variance component. The randomeffects model is the second model that we address and in this case, we examine the DerSimoman-Laird method for estimating the effect estimate. There is an additional variance component that is used in the random-effects model. This variance component addresses the variance between studies. Meta-analysis has been extensively used with clinical trials and observational studies. In available statistical software, the programs available for meta-analysis can only be used with clinical trials. The goal of this work was to modify the programs in R and SAS, so they would be suitable for use with observational studies. Using data on aspirin use and its effect on colon cancer, we demonstrate the use of the modified R and SAS code. The results presented here demonstrated how we extended the programs for metaanalysis of clinical trials to observational studies. As these are very common in medical studies, this development will allow additional analysis to be done when they are the object of a given study. The hope for this work is to provide researchers with programs suitable for meta-analysis with observational studies and clinical trials.

Author : Douglas E. Faries
Publisher : SAS Press
Page : 0 pages
File Size : 40,51 MB
Release : 2010
Category : Medical care
ISBN : 9781607642275

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This book guides researchers in performing and presenting high-quality analyses of all kinds of non-randomized studies, including analyses of observational studies, claims database analyses, assessment of registry data, survey data, pharmaco-economic data, and many more applications. The text is sufficiently detailed to provide not only general guidance, but to help the researcher through all of the standard issues that arise in such analyses. Just enough theory is included to allow the reader to understand the pros and cons of alternative approaches and when to use each method. The numerous contributors to this book illustrate, via real-world numerical examples and SAS code, appropriate implementations of alternative methods. The end result is that researchers will learn how to present high-quality and transparent analyses that will lead to fair and objective decisions from observational data. This book is part of the SAS Press program.

Author : Winfred Arthur, Jr.
Publisher : Psychology Press
Page : 200 pages
File Size : 12,81 MB
Release : 2001-06-01
Category : Psychology
ISBN : 1135643458

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Conducting Meta-Analysis Using SAS reviews the meta-analysis statistical procedure and shows the reader how to conduct one using SAS. It presents and illustrates the use of the PROC MEANS procedure in SAS to perform the data computations called for by the two most commonly used meta-analytic procedures, the Hunter & Schmidt and Glassian approaches. This book serves as both an operational guide and user's manual by describing and explaining the meta-analysis procedures and then presenting the appropriate SAS program code for computing the pertinent statistics. The practical, step-by-step instructions quickly prepare the reader to conduct a meta-analysis. Sample programs available on the Web further aid the reader in understanding the material. Intended for researchers, students, instructors, and practitioners interested in conducting a meta-analysis, the presentation of both formulas and their associated SAS program code keeps the reader and user in touch with technical aspects of the meta-analysis process. The book is also appropriate for advanced courses in meta-analysis psychology, education, management, and other applied social and health sciences departments.

Author : Ding-Geng (Din) Chen
Publisher : CRC Press
Page : 378 pages
File Size : 13,60 MB
Release : 2017-06-01
Category : Mathematics
ISBN : 1498779530

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Review of the First Edition "The goal of this book, as stated by the authors, is to fill the knowledge gap that exists between developed statistical methods and the applications of these methods. Overall, this book achieves the goal successfully and does a nice job. I would highly recommend it ...The example-based approach is easy to follow and makes the book a very helpful desktop reference for many biostatistics methods."—Journal of Statistical Software Clinical Trial Data Analysis Using R and SAS, Second Edition provides a thorough presentation of biostatistical analyses of clinical trial data with step-by-step implementations using R and SAS. The book’s practical, detailed approach draws on the authors’ 30 years’ experience in biostatistical research and clinical development. The authors develop step-by-step analysis code using appropriate R packages and functions and SAS PROCS, which enables readers to gain an understanding of the analysis methods and R and SAS implementation so that they can use these two popular software packages to analyze their own clinical trial data. What’s New in the Second Edition Adds SAS programs along with the R programs for clinical trial data analysis. Updates all the statistical analysis with updated R packages. Includes correlated data analysis with multivariate analysis of variance. Applies R and SAS to clinical trial data from hypertension, duodenal ulcer, beta blockers, familial andenomatous polyposis, and breast cancer trials. Covers the biostatistical aspects of various clinical trials, including treatment comparisons, time-to-event endpoints, longitudinal clinical trials, and bioequivalence trials.

Author : Guido Schwarzer
Publisher : Springer
Page : 256 pages
File Size : 15,77 MB
Release : 2015-10-08
Category : Medical
ISBN : 3319214160

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This book provides a comprehensive introduction to performing meta-analysis using the statistical software R. It is intended for quantitative researchers and students in the medical and social sciences who wish to learn how to perform meta-analysis with R. As such, the book introduces the key concepts and models used in meta-analysis. It also includes chapters on the following advanced topics: publication bias and small study effects; missing data; multivariate meta-analysis, network meta-analysis; and meta-analysis of diagnostic studies.

Author : Ken Kleinman
Publisher : CRC Press
Page : 425 pages
File Size : 24,12 MB
Release : 2014-07-17
Category : Mathematics
ISBN : 1466584505

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An Up-to-Date, All-in-One Resource for Using SAS and R to Perform Frequent TasksThe first edition of this popular guide provided a path between SAS and R using an easy-to-understand, dictionary-like approach. Retaining the same accessible format, SAS and R: Data Management, Statistical Analysis, and Graphics, Second Edition explains how to easily p

Author : Ken Kleinman
Publisher : CRC Press
Page : 325 pages
File Size : 20,88 MB
Release : 2009-07-21
Category : Mathematics
ISBN : 1420070592

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An All-in-One Resource for Using SAS and R to Carry out Common TasksProvides a path between languages that is easier than reading complete documentationSAS and R: Data Management, Statistical Analysis, and Graphics presents an easy way to learn how to perform an analytical task in both SAS and R, without having to navigate through the extensive, id

Author : Mathias Harrer
Publisher : CRC Press
Page : 500 pages
File Size : 15,7 MB
Release : 2021-09-15
Category : Mathematics
ISBN : 1000435636

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Doing Meta-Analysis with R: A Hands-On Guide serves as an accessible introduction on how meta-analyses can be conducted in R. Essential steps for meta-analysis are covered, including calculation and pooling of outcome measures, forest plots, heterogeneity diagnostics, subgroup analyses, meta-regression, methods to control for publication bias, risk of bias assessments and plotting tools. Advanced but highly relevant topics such as network meta-analysis, multi-three-level meta-analyses, Bayesian meta-analysis approaches and SEM meta-analysis are also covered. A companion R package, dmetar, is introduced at the beginning of the guide. It contains data sets and several helper functions for the meta and metafor package used in the guide. The programming and statistical background covered in the book are kept at a non-expert level, making the book widely accessible. Features • Contains two introductory chapters on how to set up an R environment and do basic imports/manipulations of meta-analysis data, including exercises • Describes statistical concepts clearly and concisely before applying them in R • Includes step-by-step guidance through the coding required to perform meta-analyses, and a companion R package for the book

Author : Mohamed M. Shoukri
Publisher : CRC Press
Page : 497 pages
File Size : 16,45 MB
Release : 2018-04-27
Category : Mathematics
ISBN : 1315277727

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Analysis of Correlated Data with SAS and R: 4th edition presents an applied treatment of recently developed statistical models and methods for the analysis of hierarchical binary, count and continuous response data. It explains how to use procedures in SAS and packages in R for exploring data, fitting appropriate models, presenting programming codes and results. The book is designed for senior undergraduate and graduate students in the health sciences, epidemiology, statistics, and biostatistics as well as clinical researchers, and consulting statisticians who can apply the methods with their own data analyses. In each chapter a brief description of the foundations of statistical theory needed to understand the methods is given, thereafter the author illustrates the applicability of the techniques by providing sufficient number of examples. The last three chapters of the 4th edition contain introductory material on propensity score analysis, meta-analysis and the treatment of missing data using SAS and R. These topics were not covered in previous editions. The main reason is that there is an increasing demand by clinical researchers to have these topics covered at a reasonably understandable level of complexity. Mohamed Shoukri is principal scientist and professor of biostatistics at The National Biotechnology Center, King Faisal Specialist Hospital and Research Center and Al-Faisal University, Saudi Arabia. Professor Shoukri’s research includes analytic epidemiology, analysis of hierarchical data, and clinical biostatistics. He is an associate editor of the 3Biotech journal, a Fellow of the Royal Statistical Society and an elected member of the International Statistical Institute.

Author : Joachim Hartung
Publisher : John Wiley & Sons
Page : 215 pages
File Size : 16,82 MB
Release : 2011-09-20
Category : Medical
ISBN : 1118210964

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An accessible introduction to performing meta-analysis across various areas of research The practice of meta-analysis allows researchers to obtain findings from various studies and compile them to verify and form one overall conclusion. Statistical Meta-Analysis with Applications presents the necessary statistical methodologies that allow readers to tackle the four main stages of meta-analysis: problem formulation, data collection, data evaluation, and data analysis and interpretation. Combining the authors' expertise on the topic with a wealth of up-to-date information, this book successfully introduces the essential statistical practices for making thorough and accurate discoveries across a wide array of diverse fields, such as business, public health, biostatistics, and environmental studies. Two main types of statistical analysis serve as the foundation of the methods and techniques: combining tests of effect size and combining estimates of effect size. Additional topics covered include: Meta-analysis regression procedures Multiple-endpoint and multiple-treatment studies The Bayesian approach to meta-analysis Publication bias Vote counting procedures Methods for combining individual tests and combining individual estimates Using meta-analysis to analyze binary and ordinal categorical data Numerous worked-out examples in each chapter provide the reader with a step-by-step understanding of the presented methods. All exercises can be computed using the R and SAS software packages, which are both available via the book's related Web site. Extensive references are also included, outlining additional sources for further study. Requiring only a working knowledge of statistics, Statistical Meta-Analysis with Applications is a valuable supplement for courses in biostatistics, business, public health, and social research at the upper-undergraduate and graduate levels. It is also an excellent reference for applied statisticians working in industry, academia, and government.