[PDF] Down Syndrome And Alzheimers Disease eBook

Author : Elizabeth Head
Publisher : Academic Press
Page : 354 pages
File Size : 26,31 MB
Release : 2021-08-31
Category : Medical
ISBN : 0128188464

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The Neurobiology of Aging and Alzheimer Disease in Down Syndrome provides a multidisciplinary approach to the understanding of aging and Alzheimer disease in Down syndrome that is synergistic and focused on efforts to understand the neurobiology as it pertains to interventions that will slow or prevent disease. The book provides detailed knowledge of key molecular aspects of aging and neurodegeneration in Down Syndrome by bringing together different models of the diseases and highlighting multiple techniques. Additionally, it includes case studies and coverage of neuroimaging, neuropathological and biomarker changes associated with these cohorts. This is a must-have resource for researchers who work with or study aging and Alzheimer disease either in the general population or in people with Down syndrome, for academic and general physicians who interact with sporadic dementia patients and need more information about Down syndrome, and for new investigators to the aging and Alzheimer/Down syndrome arena. Discusses the complexities involved with aging and Alzheimer’s disease in Down syndrome Summarizes the neurobiology of aging that requires management in adults with DS and leads to healthier aging and better quality of life into old age Serves as learning tool to orient researchers to the key challenges and offers insights to help establish critical areas of need for further research

Author : Vee P. Prasher
Publisher : Radcliffe Publishing
Page : 206 pages
File Size : 24,92 MB
Release : 2006
Category : Alzheimer's disease
ISBN : 9781857756371

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Addresses the underlying biological abnormalities of Dementia in Alzheimer's Disease (DAD) in people with Down syndrome. Brings together recent research findings relating to the neuropathology, genetics, blood markers and neurophysiology of Alzheimer's disease in older adults with Down syndrome.

Author : Vee Prasher
Publisher : CRC Press
Page : 199 pages
File Size : 33,55 MB
Release : 2018-12-14
Category : Medical
ISBN : 149879288X

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This is the first book in the field to address the underlying biological abnormalities of Dementia in Alzheimer’s Disease (DAD) in people with Down syndrome. It brings together research findings relating to the neuropathology, genetics, blood markers and neurophysiology of Alzheimer’s disease in older adults with Down syndrome. Down Syndrome and Alzheimer’s Disease presents vital information to medical professionals who provide clinical care to people with Alzheimer’s disease and Down syndrome. It will also be of great benefit to researchers with an interest in Alzheimer’s disease and Down syndrome and academics researching ageing issues in people with Down Syndrome. It complements Alzheimer's Disease and Dementia in Down Syndrome and Intellectual Disabilities by the same author.

Author : Vee P. Prasher
Publisher : Springer Science & Business Media
Page : 222 pages
File Size : 45,11 MB
Release : 2009-04-29
Category : Medical
ISBN : 1848002491

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This book reviews important neuropsychological measures currently used in the assessment of dementia by the principal clinicians and researchers associated with the test, offering practical guidance on each test along with an analysis of its limitations.

Author : Marie-Claude Potier
Publisher : Frontiers Media SA
Page : 183 pages
File Size : 47,77 MB
Release : 2017-02-24
Category :
ISBN : 2889450457

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Research on the multiple aspects of cognitive impairment in Down syndrome (DS), from genes to behavior to treatment, has made tremendous progress in the last decade. The study of congenital intellectual disabilities such as DS is challenging since they originate from the earliest stages of development and both the acquisition of cognitive skills and neurodegenerative pathologies are cumulative. Comorbidities such as cardiac malformations, sleep apnea, diabetes and dementia are frequent in the DS population, as well, and their increased risk provides a means of assessing early stages of these pathologies that is relevant to the general population. Notably, persons with DS will develop the histopathology of Alzheimer’s disease (formation of neuritic plaques and tangles) and are at high risk for dementia, something that cannot be predicted in the population at large. Identification of the gene encoding the amyloid precursor protein, its localization to chromosome 21 in the 90’s and realization that all persons with DS develop pathology identified this as an important piece of the amyloid cascade hypothesis in Alzheimer’s disease. Awareness of the potential role of people with DS in understanding progression and treatment as well as identification of genetic risk factors and also protective factors for AD is reawakening. For the first time since DS was recognized, major pharmaceutical companies have entered the search for ameliorative treatments, and phase II clinical trials to improve learning and memory are in progress. Enriched environment, brain stimulation and alternative therapies are being tested while clinical assessment is improving, thus increasing the chances of success for therapeutic interventions. Researchers and clinicians are actively pursuing the possibility of prenatal treatments for many conditions, an area with a huge potential impact for developmental disorders such as DS. Our goal here is to present an overview of recent advances with an emphasis on behavioral and cognitive deficits and how these issues change through life in DS. The relevance of comorbidities to the end phenotypes described and relevance of pharmacological targets and possible treatments will be considerations throughout.

Author : Günther Witzany
Publisher : Springer Science & Business Media
Page : 432 pages
File Size : 34,59 MB
Release : 2012-11-13
Category : Science
ISBN : 940074899X

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A renaissance of virus research is taking centre stage in biology. Empirical data from the last decade indicate the important roles of viruses, both in the evolution of all life and as symbionts of host organisms. There is increasing evidence that all cellular life is colonized by exogenous and/or endogenous viruses in a non-lytic but persistent lifestyle. Viruses and viral parts form the most numerous genetic matter on this planet.

Author : Bob Dawson
Publisher : Sharing Good Practice
Page : 86 pages
File Size : 48,66 MB
Release : 2020-10-30
Category : Health & Fitness
ISBN : 9781789631678

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A guide for carers who are supporting people with Down Syndrome who develop dementia.

Author : Vee P. Prasher
Publisher : Radcliffe Publishing
Page : 164 pages
File Size : 40,38 MB
Release : 2005
Category : Alzheimer's disease
ISBN : 9781857756081

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The basic aim of this book is to help carers and professionals living or working with adults with intellectual disability to understand further Alzheimer's disease and other forms of dementia.

Author : Karen Watchman
Publisher : Jessica Kingsley Publishers
Page : 122 pages
File Size : 11,17 MB
Release : 2017-03-21
Category : Family & Relationships
ISBN : 1784501840

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Selected for Reading Well for Dementia 2024: endorsed by health experts, charities and people affected by dementia. Drawing on the author's first-hand experiences with families, this book provides crucial, accessible information and answers the difficult questions that often arise when a family member with an intellectual disability is diagnosed with dementia. Linking directly to policy and practice in both dementia and intellectual disability care, this book takes an outcome-focussed approach to support short, medium and long-term planning. With a particular emphasis on communication, the author seeks to ensure that families and organisations are able to converse effectively about a relative's health and care. The book looks at how to recognise when changes in the health of a relative with an intellectual disability could indicate the onset of dementia, as well as addressing common concerns surrounding living situations, medication and care plans. Each chapter is structured to identify strategies for support whilst working towards outcomes identified by families as dementia progresses.