[PDF] Developmental Aspects Of The Lymphatic Vascular System eBook
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The book focuses on the lymphatic vascular system from a developmental biologist’s point of view. It provides an overview on the many recent advances in understanding the development of lymphatic vessels, using advanced genetic models in conjunction with state of the art imaging. For each chapter a synopsis is provided, highlighting the main points in a concise manner. The book is intended for professors and researchers in vascular biology, angiogenesis research and developmental biology. It furthermore offers an excellent basis for entry level researchers and newcomers to this field, as well as for teachers, graduate students, advanced science and medical students.
The partition of fluid between the vascular and interstitial compartments is regulated by forces (hydrostatic and oncotic) operating across the microvascular walls and the surface areas of permeable structures comprising the endothelial barrier to fluid and solute exchange, as well as within the extracellular matrix and lymphatics. In addition to its role in the regulation of vascular volume, transcapillary fluid filtration also allows for continuous turnover of water bathing tissue cells, providing the medium for diffusional flux of oxygen and nutrients required for cellular metabolism and removal of metabolic byproducts. Transendothelial volume flow has also been shown to influence vascular smooth muscle tone in arterioles, hydraulic conductivity in capillaries, and neutrophil transmigration across postcapillary venules, while the flow of this filtrate through the interstitial spaces functions to modify the activities of parenchymal, resident tissue, and metastasizing tumor cells. Likewise, the flow of lymph, which is driven by capillary filtration, is important for the transport of immune and tumor cells, antigen delivery to lymph nodes, and for return of filtered fluid and extravasated proteins to the blood. Given this background, the aims of this treatise are to summarize our current understanding of the factors involved in the regulation of transcapillary fluid movement, how fluid movements across the endothelial barrier and through the interstitium and lymphatic vessels influence cell function and behavior, and the pathophysiology of edema formation. Table of Contents: Fluid Movement Across the Endothelial Barrier / The Interstitium / The Lymphatic Vasculature / Pathophysiology of Edema Formation
Lymphatic Structure and Function in Health and Disease serves as a resource book on what has been learned about lymphatic structure, function and anatomy within different organ systems. This is the first book to bring together lymphatic medicine as a whole, with in-depth analysis of specific aspects of lymphatics in different vascular pathologies. This book is a useful tool for scientists, practicing clinicians and residents, in particular, those in vascular biology, neurology, cardiology and general medicine. Chapters discuss topics such as ontogeny and phylogeny of lymphatics, lymphatic pumping, CNS lymphatics, lymphatics in transplant and lymphatic reconstruction. Brings together lymphatic medicine as a whole, with an in-depth analysis of the specific basic science aspects of lymphatic structure and function Covers the clinical aspects of lymphatics in different vascular pathologies Co-published with the International Society of Neurovascular Diseases Discusses lymphatic structure and function in all of the major organ systems
The human immune system is a complex network of tissues and organs dispersed throughout the body. Immunology, as one of the most rapidly evolving fields in bio¬medical research, has to date covered the essential cellular and molecular events neces¬sary for immune responses to occur. However, it has paid relatively little attention to important developmental processes underlying the formation of the tissues themselves that carry out immune responses in humans and other mammalians. In contrast to the thymus and bone marrow that are the sole tissues for generating mature leukocytes for antigen recognition and han¬dling in humans and most mammalian species, the peripheral lymphoid tissues where adaptive immune responses are focused display broad tissue distribution and possess diverse archi¬tectural characteristics. These organs develop prior to the individual’s exposure to external antigens, and despite their similar functions, their varied appearances indicate a substantial complexity of tissue ontogeny. This volume presents a comprehensive overview of the developmental features of the major peripheral lymphoid organs, thus examining the connection between immunological functionality and structural characteristics utilizing a developmental approach, for an audience ranging from undergraduate students to senior researchers in immunology, histology and clinical medicine.
The formation of blood vessels is an essential aspect of embryogenesis in vertebrates. It is a central feature of numerous post-embryonic processes, including tissue and organ growth and regeneration. It is also part of the pathology of tumour formation and certain inflammatory conditions. In recent years, comprehension of the molecular genetics of blood vessel formation has progressed enormously and studies in vertebrate model systems, especially the mouse and the zebrafish, have identified a common set of molecules and processes that are conserved throughout vertebrate embryogenesis while, in addition, highlighting aspects that may differ between different animal groups. The discovery in the past decade of the crucial role of new blood vessel formation for the development of cancers has generated great interest in angiogenesis (the formation of new blood vessels from pre-existing ones), with its major implications for potential cancer-control strategies. In addition, there are numerous situations where therapeutic treatments either require or would be assisted by vasculogenesis (the de novo formation of blood vessels). In particular, post-stroke therapies could include treatments that stimulate neovascularization of the affected tissues. The development of such treatments, however, requires thoroughly understanding the developmental properties of endothelial cells and the basic biology of blood vessel formation. While there are many books on angiogenesis, this unique book focuses on exactly this basic biology and explores blood vessel formation in connection with tissue development in a range of animal models. It includes detailed discussions of relevant cell biology, genetics and embryogenesis of blood vessel formation and presents insights into the cross-talk between developing blood vessels and other tissues. With contributions from vascular biologists, cell biologists and developmental biologists, a comprehensive and highly interdisciplinary volume is the outcome.
The placenta is an organ that connects the developing fetus to the uterine wall, thereby allowing nutrient uptake, waste elimination, and gas exchange via the mother's blood supply. Proper vascular development in the placenta is fundamental to ensuring a healthy fetus and successful pregnancy. This book provides an up-to-date summary and synthesis of knowledge regarding placental vascular biology and discusses the relevance of this vascular bed to the functions of the human placenta.
This book provides a comprehensive account of vascular biology and pathology and its significance for health and disease. It systematically and chronologically explains how we came to our current understanding of the vasculature and it ́s function today, and describes in an entertaining way the diverse flaws and turns in science and medicine from the past. It thereby offers a complete and well-studied history on vascular biology and medicine. The book has an easy-to-read style and is written for students as well as scientists, physicians and lecturers in the field of biomedicine, human physiology, cardiology and hematology.
New Insights on the Development of the Vascular System examines the most recent literature and data on the development of the vascular system, along with advice on new laboratory techniques and approaches to data analysis. This volume is a comprehensive handbook to the state-of-the-art in vascular system development. Several genetic and epigenetic mechanisms are involved in the early development of the vascular system, and there is extensive literature on the genetic background and molecular mechanisms responsible for blood vessel formation. Yet new data and techniques have been developed in recent years. Although scientific literature covers the descriptive aspects of embryonic vascular system development, modern techniques such as the technology of cell fusion, cell sorting and image analysis give new insight into the mechanisms by which vessels form and regress and how blood flow changes directions in the same vessels. Gives a comprehensive overview of the most recent literature in the field of vascular system development Presents new data, including sections on endothelial cell signaling and technologies of cell fusion, cell sorting and image analysis Provides useful insights on the analysis of new experimental work Suggests modern techniques for scientists to use in the lab Gives an overview of vascular biology that will be useful for those needing rapid familiarity Provides an expert guide to the state-of-the-art in vascular system development as written by a leader in the field