[PDF] Development Of Mucoadhesive Carrier Systems For Flavoring Agents And Cannabidiol eBook

Author : Ulrike Söpper
Publisher :
Page : pages
File Size : 25,19 MB
Release : 2021
Category :
ISBN :

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The buccal mucosa represents an attractive site to realize both local and systemic effects. It is easily accessible and transbuccal drug delivery offers the opportunity to increase bioavailability of drugs by avoiding first-pass metabolism and intestinal drug degradation. But despite numerous advantages, it remains challenging to exploit the full potential of the buccal region. The main limitations derive from the barrier properties of the mucosa and the removal mechanism by the salivary flow in the oral cavity. Therefore, an effective buccal drug delivery formulation requires adequate adhesion and, for systemic effects, additionally sufficient mucosal penetration. Three objectives were investigated in this work. The first one was to develop carrier systems based on a flavor-loaded porous silica and a mucoadhesive polymer. In addition to stabilizing the volatile flavor, the carrier system was intended to use mucoadhesion to prolong the effects of flavoring agents in the oral cavity. The second part of the work investigated whether the formulation approach can also be transferred to drug-loaded carrier systems. For this purpose, CBD was selected as a model API given its strong need for an alternative administration route based on its poor oral bioavailability. It was hypothesized that the mucoadhesive delivery systems would result in an extended and intimate contact with the mucosa, and thereby favor the absorption of CBD. Finally, regarding taste compliance, it was of interest to clarify whether mucoadhesive carrier systems with a combination of flavoring agent and CBD are feasible. The results demonstrated that functionalization of flavor-loaded silica carrier systems with mucoadhesive polymers is a promising formulation approach for prolonged availability of flavors in the oral cavity. Stability studies confirmed that the volatile flavors can be stabilized by the formulations in the carrier systems for months. DSC studies revealed that the decisive factor for stability was the physical state of the flavor in the carrier system. The flavor content was stable, when the load limit of the silica was not exceeded, and the flavoring agent was completely deposited in an amorphous state to the silica carrier. The improved adhesion of the flavoring agents to the oral mucosa was evaluated by ex-vivo mucoadhesion studies. Among the tested formulations, the combination of Aeroperl 300 as the carrier material, sunflower oil as a coating medium and carbomer as the mucoadhesive polymer proved to be superior in terms of a strong and long-lasting mucoadhesive effect than other combinations. In summary, a large surface area and large pore volume of the silica proved to be desirable for the loading and coating process. The magnitude of the mucoadhesive effect was determined by the polymer concentration, the ability of the polymer to form bonds with the mucus layer, its particle size and the coating medium applied.

Author : Michael J. Rathbone
Publisher : Springer
Page : 289 pages
File Size : 38,27 MB
Release : 2015-03-13
Category : Medical
ISBN : 1489975586

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This volume provides a comprehensive overview of the current issues facing scientists working on delivering drugs locally and systemically via the membranes that line the mouth. The book describes the anatomical and physiological challenges of this route for drug delivery and how they impact the design of oral mucosal drug delivery systems. It also provides a detailed description of current oral mucosal drug delivery technologies that overcome these challenges alongside research, development and assessment methods. In 11 authoritative chapters, the book affords an in-depth evaluation of the major issues associated with this route of administration, namely the retention of the drug/product at the site of administration and increasing drug permeability through the oral mucosa. The book provides insights into the in vitro and in vivo methods available to assess drug permeability and retention, offers solutions on how to improve the permeation of the drugs through the oral mucosa, and explores approaches to prolong drug/product retention at the site of administration. It also indicates future directions in research and product development. Oral Mucosal Drug Delivery and Therapy is a key resource for those wishing to extend their knowledge of this field.

Author : Mohammad Jawaid
Publisher : Springer Nature
Page : 289 pages
File Size : 47,83 MB
Release : 2021-01-21
Category : Technology & Engineering
ISBN : 981334749X

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This book provides an overview of eco-friendly resins and their composite materials covering their synthesis, sources, structures and properties for different industrial applications to support the ongoing research and development in eco-friendly and renewable commercial products. It provides comparative discussions on the properties of eco-friendly resins with other polymer composites. It is a useful reference on bio-based eco-friendly polymer resins, wood-based composites, natural fibers and biomass materials for the polymer scientists, engineers and material scientists.

Author : Munish Puri
Publisher : Springer
Page : 329 pages
File Size : 44,93 MB
Release : 2017-04-07
Category : Technology & Engineering
ISBN : 3319516396

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This book focuses on various types of bioactive compounds, including secondary metabolites, oligosaccharides, polysaccharides, flavonoids, peptides/proteins, carotenoid pigments, quinones, terpenes, and polyunsaturated fatty acids, and presents an overview of their nutraceutical activities. It covers the current status and future potential of food compounds, as well as extraction technologies for bioactives derived from plant, fungi and marine-derived bioactive agents. Finally, health-promoting effects of plant, fungi and marine-derived bioactive agents are discussed. Chapters come from top researchers in this area from around the globe. The volume caters to the needs of undergraduate and post-graduate students in the area of food biotechnology, food bioprocessing, biotechnology, food engineering, etc., and also contains information pertinent to researchers.

Author : Saikat Sen
Publisher : Springer Nature
Page : 612 pages
File Size : 23,68 MB
Release : 2019-09-10
Category : Medical
ISBN : 9811372489

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This book highlights the medical importance of and increasing global interest in herbal medicines, herbal health products, herbal pharmaceuticals, nutraceuticals, food supplements, herbal cosmetics, etc. It also addresses various issues that are hampering the advancement of Indian herbal medicine around the globe; these include quality concerns and quality control, pharmacovigilance, scientific investigation and validation, IPR and biopiracy, and the challenge that various indigenous systems of medicine are at risk of being lost. The book also explores the role of traditional medicine in providing new functional leads and modern approaches that can offer elegant strategies for facilitating the drug discovery process. The book also provides in-depth information on various traditional medicinal systems in India and discusses their medical importance. India has a very long history of safely using many herbal drugs. Folk medicine is also a key source of medical knowledge and plays a vital role in maintaining health in rural and remote areas. Despite its importance, this form of medicine largely remains under-investigated. Out of all the traditional medicinal systems used worldwide, Indian traditional medicine holds a unique position, as it has continued to deliver healthcare throughout the Asian subcontinent since ancient times. In addition, traditional medicine has been used to derive advanced techniques and investigate many modern drugs. Given the scope of its coverage, the book offers a valuable resource for scientists and researchers exploring traditional and herbal medicine, as well as graduate students in courses on traditional medicine, herbal medicine and pharmacy.

Author : David Farrar
Publisher : Elsevier
Page : 672 pages
File Size : 26,86 MB
Release : 2011-06-21
Category : Medical
ISBN : 0857093304

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Wound repair is an important and growing sector of the medical industry with increasingly sophisticated biomaterials and strategies being developed to treat wounds. Advanced wound repair therapies provides readers with up-to-date information on current and emerging biomaterials and advanced therapies concerned with healing surgical and chronic wounds.Part one provides an introduction to chronic wounds, with chapters covering dysfunctional wound healing, scarring and scarless wound healing and monitoring of wounds. Part two covers biomaterial therapies for chronic wounds, including chapters on functional requirements of wound repair biomaterials, polymeric materials for wound dressings and interfacial phenomena in wound healing. In part three, molecular therapies for chronic wounds are discussed, with chapters on topics such as drug delivery, molecular and gene therapies and antimicrobial dressings. Part four focuses on biologically-derived and cell-based therapies for chronic wounds, including engineered tissues, biologically-derived scaffolds and stem cell therapies for wound repair. Finally, part five covers physical stimulation therapies for chronic wounds, including electrical stimulation, negative pressure therapy and mechanical debriding devices.With its distinguished editor and international team of contributors, Advanced wound repair therapies is an essential reference for researchers and materials scientists in the wound repair industry, as well as clinicians and those with an academic research interest in the subject. Provides readers with up-to-date information on current and emerging biomaterials and advanced therapies concerned with healing surgical and chronic wounds Chapters include the role of micro-organisms and biofilms in dysfunctional wound healing, tissue-biomaterial interaction and electrical stimulation for wound healing Covers biologically-derived and cell-based therapies for chronic wounds, including engineered tissues, biologically-derived scaffolds and stem cell therapies for wound repair

Author : Mallappa Kumara Swamy
Publisher : Springer Nature
Page : 492 pages
File Size : 15,74 MB
Release : 2019-09-19
Category : Science
ISBN : 9811372055

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Nature has consistently provided human beings with bioactive compounds that can be used directly as drugs or indirectly as drug leads. Some of the major classes of natural bioactive compounds include phenolics, alkaloids, tannins, saponins, lignin, glycosides, terpenoids, and many more. They possess a broad range of biological activities and are primarily useful in the treatment of various health issues. At the same time, the search for new and novel drugs is never-ending and, despite major advances in synthetic chemistry, nature remains an essential resource for drug discovery. Therefore, more and more researchers are interested in understanding the chemistry, clinical pharmacology, and beneficial effects of bioactive compounds in connection with solving human health problems. This book presents a wealth of information on natural metabolites that have been or are currently being used as drugs or leads for the discovery of new drugs. In addition, it highlights the importance of natural products against various human diseases, and their applications in the drug, nutraceuticals, cosmetics and herbal industries. Accordingly, the book offers a valuable resource for all students, educators, and healthcare experts involved in natural product research, phytochemistry, and pharmacological research.

Author : Azamal Husen
Publisher : Springer Nature
Page : 479 pages
File Size : 38,1 MB
Release : 2021-07-30
Category : Science
ISBN : 3030730778

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Forests cover thirty-one percent of the world’s land surface, provide habitats for animals, livelihoods for humans, and generate household income in rural areas of developing countries. They also supply other essential amenities, for instance, they filter water, control water runoff, protect soil erosion, regulate climate, store nutrients, and facilitate countless non-timber forest products (NTFPs). The main NTFPs comprise herbs, grasses, climbers, shrubs, and trees used for food, fodder, fuel, beverages, medicine, animals, birds and fish for food, fur, and feathers, as well as their products, like honey, lac, silk, and paper. At present, these products play an important role in the daily life and well-being of millions of people worldwide. Hence the forest and its products are very valuable and often NTFPs are considered as the ‘potential pillars of sustainable forestry’. NTFPs items like food, herbal drugs, forage, fuel-wood, fountain, fibre, bamboo, rattans, leaves, barks, resins, and gums have been continuously used and exploited by humans. Wild edible foods are rich in terms of vitamins, protein, fat, sugars, and minerals. Additionally, some NTFPs are used as important raw materials for pharmaceutical industries. Numerous industry-based NTFPs are now being exported in considerable quantities by developing countries. Accordingly, this sector facilitates employment opportunities in remote rural areas. So, these developments also highlight the role of NTFPs in poverty alleviation in different regions of the world. This book provides a wide spectrum of information on NTFPs, including important references. We hope that the compendium of chapters in this book will be very useful as a reference book for graduate and postgraduate students and researchers in various disciplines of forestry, botany, medical botany, economic botany, ecology, agroforestry, and biology. Additionally, this book should be useful for scientists, experts, and consultants associated with the forestry sector.

Author : Henk G. Merkus
Publisher : Springer
Page : 0 pages
File Size : 32,17 MB
Release : 2016-08-23
Category : Science
ISBN : 9783319343419

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Particulate products make up around 80% of chemical products, from all industry sectors. Examples given in this book include the construction materials, fine ceramics and concrete; the delicacies, chocolate and ice cream; pharmaceutical, powders, medical inhalers and sun screen; liquid and powder paints. Size distribution and the shape of the particles provide for different functionalities in these products. Some functions are general, others specific. General functions are powder flow and require – at the typical particulate concentrations of these products – that the particles cause adequate rheological behavior during processing and/or for product performance. Therefore, this book addresses particle packing as well as its relation to powder flow and rheological behavior. Moreover, general relationships to particle size are discussed for e.g. color and sensorial aspects of particulate products. Product-specific functionalities are often relevant for comparable product groups. Particle size distribution and shape provide, for example, the following functionalities: - dense particle packing in relation to sufficient strength is required in concrete construction, ceramic objects and pharmaceutical tablets - good sensorial properties (mouthfeel) to chocolate and ice cream - effective dissolution, flow and compression properties for pharmaceutical powders - adequate hiding power and effective coloring of paints for protection and the desired esthetical appeal of the objects - adequate protection of our body against sun light by sunscreen - effective particle transport and deposition to desired locations for medical inhalers and powder paints. Adequate particle size distribution, shape and porosity of particulate products have to be achieved in order to reach optimum product performance. This requires adequate management of design and development as well as sufficient knowledge of the underlying principles of physics and chemistry. Moreover, flammability, explosivity and other health hazards from powders, during handling, are taken into account. This is necessary, since great risks may be involved. In all aspects, the most relevant parameters of the size distribution (and particle shape) have to be selected. In this book, experts in the different product fields have contributed to the product chapters. This provides optimum information on what particulate aspects are most relevant for behavior and performance within specified industrial products and how optimum results can be obtained. It differs from other books in the way that the critical aspects of different products are reported, so that similarities and differences can be identified. We trust that this approach will lead to improved optimization in design, development and quality of many particulate products.

Author : Ankit Saneja
Publisher : Springer Nature
Page : 278 pages
File Size : 41,24 MB
Release : 2020-04-30
Category : Medical
ISBN : 3030418421

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This book covers nanotechnology based approaches for improving the therapeutic efficacy of natural products. It critically explores lipid nanoarchitectonics, inorganic particles and nanoemulsion based tools for delivering them. With its chapters from eminent experts working in this discipline, it is ideal for researchers and professionals working in the area.