[PDF] Design Recommendations For Pharmacogenomics Clinical Decision Support Systems eBook

Author : Maher Khelifi
Publisher :
Page : 42 pages
File Size : 18,16 MB
Release : 2015
Category :
ISBN :

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The use of pharmacogenomics (PGx)in clinical practice is still facing several challenges in reaching full adoption. PGx is an emerging field that aims to deploy genetic information to target drug therapy. To incorporate this science into clinical practice, many support the use of Pharmacogenomics Clinical Decision Support Systems (PGx-CDS) for medication prescriptions. This interest emerged with the new guidelines developed to incorporate genetics to optimize drug dosage and reduce adverse events. In my thesis, I investigate the development of PGx-CDS to (1) identify challenges and barriers of the implementation of PGx-CDS in clinical settings, (2) develop a new design approach of CDS with functional characteristics that can improve the adoption of Pharmacogenomics guidelines and improve patient safety, and (3) create design guidelines and recommendations. Through this work, I aim to study the implementation of PGx-CDS and develop design features that can overcome the challenges of its adoption in clinical settings.

Author : Beth Devine
Publisher : Academic Press
Page : 300 pages
File Size : 36,29 MB
Release : 2022-06-14
Category : Medical
ISBN : 0128244542

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Clinical Decision Support for Pharmacogenomic Precision Medicine: Foundations and Implementation offers overviews, methods and strategies for translating genomic medicine to clinical practice. The book's authors explore incorporating pharmacogenetics into electronic health records, CDS methods and infrastructure for delivery, economic evaluation, the hospital administrations’ role and needs in integration, and patient counseling aspects. The book empowers clinicians, researchers, translational scientists, and data and IT experts to effectively navigate the complex landscape of CDS for pharmacogenomic precision medicine. Illustrative case studies of existing gene networks include CSER, eMERGE, the IGNITE network, DIGITIZE, the CDS Learning Network (RTI), ClinGen, Ubiquitous and CDS Hooks. Offers an applied, case-driven discussion of CDS for pharmacogenomic precision medicine Illustrates key concepts, contemporary developments, and future directions using examples of existing gene networks Features contributions from leading voices in precision medicine and clinical decision support

Author : M. Schwab
Publisher : Karger Medical and Scientific Publishers
Page : 148 pages
File Size : 11,51 MB
Release : 2010-06-25
Category : Medical
ISBN : 3805594992

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In recent years, there have been major developments in the fields of pharmacogenetics and pharmacogenomics, with the potential to make drug treatments in psychiatric medicine more effective. However, improvements in drug efficacy and tolerability, as well as finding the optimal dosage, can only be realized if in vivo mechanisms of drug action and ADME (absorption, distribution, metabolism, excretion) processes (pharmacokinetics) of psychopharmacological agents are better understood. In this volume, current progress and perspectives in pharmacogenetic testing of drug-metabolizing enzymes, drug transporters and other drug targets involved in the response to psychotropic agents are described extensively. This provides a timely overview of what has been achieved in the area of psychiatric pharmacogenomics alongside some promising directions and perspectives for future research.Psychiatrists, general medical doctors as well as pharmacologists and clinical pharmacologists will find new insights into the development and applications of pharmacogenomics in psychiatry.

Author : Michael S. Wogalter
Publisher : CRC Press
Page : 365 pages
File Size : 20,73 MB
Release : 1999-09-09
Category : Technology & Engineering
ISBN : 0203983831

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Questions regarding how best to communicate warnings and risk information, whether such communications are likely to be effective, and what factors influence the communication process are important across many of society's facets today. Stimulated by the tremendous growth in litigation on product liability and associated personal injury, research i

Author : Carolyn R. Rohrer Vitek
Publisher :
Page : 194 pages
File Size : 44,76 MB
Release : 2018
Category : Grounded theory
ISBN :

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Pharmacogenomics is an emerging field that uses how genes influence response to medications to improve medication safety and efficacy; however, many clinicians lack knowledge of how to use this information. Computer clinical decision support (CDS) systems have been developed for electronic prescribing that provide pharmacogenomics information and recommendations to guide clinician decision-making at the time of prescribing. Yet, the process of decision-making following a pharmacogenomics alert is incompletely understood. Understanding this process is critical to understanding decision making and future CDS development. This exploratory grounded theory study interviewed 15 healthcare professionals to understand the factors and processes that influence a clinician's decision-making following a pharmacogenomics alert. A three-stage model incorporating factors, processes, and consequences emerged. A complex combination of situational factors, including the patient presentation, clinician knowledge and perspective, and patient-clinician relationship provide a contextual basis and influence a prescriber's decision-making. Following the pharmacogenomics alert, clinicians use a series of processes prior to making a prescription decision: situating, assessing, and obtaining information. The resulting actual and anticipated consequences create a feedback loop, thus serving as inputs for future decision-making. The decision-making that occurs when a pharmacogenomics alert is presented creates a unique series of events that influences future decision-making. The resulting preliminary theoretical model of a clinician's pharmacogenomics decision-making following an alert deserves further investigation to enhance generalizability and may be used to better implement CDS and inform future education efforts.

Author : Terrence Adam
Publisher : Springer Nature
Page : 349 pages
File Size : 45,59 MB
Release : 2019-09-17
Category : Medical
ISBN : 3030186261

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This book adopts an integrated and workflow-based treatment of the field of personalized and precision medicine (PPM). Outlined within are established, proven and mature workflows as well as emerging and highly-promising opportunities for development. Each workflow is reviewed in terms of its operation and how they are enabled by a multitude of informatics methods and infrastructures. The book goes on to describe which parts are crucial to discovery and which are essential to delivery and how each of these interface and feed into one-another. Personalized and Precision Medicine Informatics provides a comprehensive review of the integrative as well as interpretive nature of the topic and brings together a large body of literature to define the topic and ensure that this is the key reference for the topic. It is an unique contribution that is positioned to be an essential guide for both PPM experts and non-experts, and for both informatics and non-informatics professionals.

Author : Anand S Dighe
Publisher : Elsevier Health Sciences
Page : pages
File Size : 17,47 MB
Release : 2019-05-08
Category : Medical
ISBN : 0323681166

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This issue of Clinics in Laboratory Medicine, Guest Edited by Dr. Anand S. Dighe, will focus on Clinical Decision Support, including tools, strategies, and emerging technologies. This issue is one of four issues selected per year by the series Consulting Editor, Milenko Jovan Tanasijevic. Topics include, but are not limited to, The Laboratory’s Role in Clinical Decision Support, Integrating Decision Support into a Utilization Management Program, Decision Support Tools within the Electronic Health Record, Decision Support to Enhance Automated Testing and Laboratory Workflow, Laboratory-based CDS programs, Decision Support in Blood Banking, Decision Support in Molecular Pathology, A Computational Perspective on Decision Support, Emerging Decision Support Techniques, Decision Support and Patient Safety, Decision Support from a Reference laboratory perspective, and Training Aspects of Laboratory Based Decision Support.

Author : Yui-Wing Francis Lam
Publisher : Academic Press
Page : 515 pages
File Size : 14,16 MB
Release : 2013-02-12
Category : Science
ISBN : 0123983037

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Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation includes discussions and viewpoints from the academic, regulatory, pharmaceutical, clinical, socio-ethical and economic perspectives. Each chapter presents an overview of the potential or opportunity within the areas discussed and also outlines foreseeable challenges and limitations in moving pharmacogenomics into drug development and direct therapeutic applications. This edited book contains review questions for a more in-depth analysis of the implications of pharmacogenomics and discussion points to generate ideas on best to move the field forward. Clinical pearls and case studies are used to illustrate real-life experiences and both successful and unsuccessful applications. Tables, figures, and annotations are included throughout the book to facilitate understanding and further reference. Multi-contributed book and chapters are written by contributors who are experts in their field Provides perspectives from those involved in all aspects of pharmacogenomics—including academic, regulatory, economic, industry and medical—to illustrate how all of the pieces fit together and where the challenges may be Includes case studies of both successful and unsuccessful applications so readers can consider the potential and challenges in moving the science into drug development and direct therapeutic applications Chapters contain discussion questions and clinical pearls and enable readers to reflect on how to move pharmacogenomics forward and apply these observations and useful tips to their own work and research

Author : Weimin Cai
Publisher : Springer Nature
Page : 290 pages
File Size : 50,18 MB
Release : 2020-06-12
Category : Medical
ISBN : 9811538956

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This book provides an introduction to the principles of pharmacogenomics and precision medicine, followed by the pharmacogenomics aspects of major therapeutic areas such as cardiovascular disease, cancer, organ transplantation, psychiatry, infection, antithrombotic drugs. It also includes genotyping technology and therapeutic drug monitoring in Pharmacogenomics; ethical, Legal and Regulatory Issues; cost-effectiveness of pharmacogenetics-guided treatment; application of pharmacogenomics in drug discovery and development and clinical Implementation of Pharmacogenomics for Personalized Precision Medicine. The contributors of Pharmacogenomics in Precision Medicine come from a team of experts, including professors from academic institutions and practitioner from hospital. It will give an in-depth overview of the current state of pharmacogenomics in drug therapy for all health care professionals and graduate students in the era of precision medicine.

Author : Geoffrey S. Ginsburg
Publisher : Academic Press
Page : 379 pages
File Size : 24,5 MB
Release : 2022-04-09
Category : Science
ISBN : 0128006536

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Genomic and Precision Medicine: Oncology, Third Edition focuses on the applications of genome discovery as research points to personalized cancer therapies. Each chapter is organized to cover the application of genomics and personalized medicine tools and technologies to a) Risk Assessment and Susceptibility, b) Diagnosis and Prognosis, c) Pharmacogenomics and Precision Therapeutics, and d) Emerging and Future Opportunities in the field. Provides a comprehensive volume written and edited by oncology genomic specialists for oncology health providers Includes succinct commentary and key learning points that will assist providers with their local needs for implementation of genomic and personalized medicine into practice Presents an up-to-date overview on major opportunities for genomic and personalized medicine in practice Covers case studies that highlight the practical use of genomics in the management of patients