[PDF] Contribution Of The Extracellular Collagen Matrix To The Mechanics Of Ventricular Myocardium eBook

Author : Pawan K. Singal
Publisher : Springer Science & Business Media
Page : 464 pages
File Size : 36,92 MB
Release : 2012-12-06
Category : Medical
ISBN : 1461520037

GET BOOK

Mechanisms of Heart Failure is based on papers selected from poster presentations made at the International Conference on Heart Failure, Winnipeg, May 20-23, 1994. Although the entire book is one continuous discussion of subcellular mechanisms of heart failure and its treatment, the presentation has been divided into three sections: the opening section on the subcellular basis of heart failure includes discussions of cytokines, signal transduction, metabolism, extracellular matrix, organ level changes and newer approaches to understanding the pathogenesis of heart failure. The second section focuses on the pathophysiological aspects of cardiomyopathies and their treatment. In the final section, medical, surgical and pharmacological approaches to the treatment of heart failure are discussed in clinical and animal laboratory settings.

Author : Zhijie Wang
Publisher :
Page : 0 pages
File Size : 12,89 MB
Release : 2019
Category : Science
ISBN :

GET BOOK

The extracellular matrix (ECM) forms a mesh surrounding tissue, made up of fibrous and non-fibrous proteins that contribute to the cellular function, mechanical properties of the tissue and physiological function of the organ. The cardiac ECM remodels in response to mechanical alterations (e.g., pressure overload, volume overload) or injuries (e.g., myocardial infarction, bacterial infection), which further leads to mechanical and functional changes of the heart. Collagen, the most prevalent ECM protein in the body, contributes significantly to the mechanical behavior of myocardium during disease progression. Alterations in collagen fiber morphology and alignment, isoform, and cross-linking occur during the progression of various cardiac diseases. Acute or compensatory remodeling of cardiac ECM maintains normal cardiac function. However, chronic or decompensatory remodeling eventually results in heart failure, and the exact mechanism of transition into maladaptation remains unclear. This review aims to summarize the primary role of collagen accumulation (fibrosis) in heart failure progression, with a focus on its effects on myocardial tissue mechanical properties and cellular and organ functions.

Author : Gianfranco Sinagra
Publisher : Springer
Page : 241 pages
File Size : 36,85 MB
Release : 2019-05-17
Category : Medical
ISBN : 303013864X

GET BOOK

This open access book presents a comprehensive overview of dilated cardiomyopathy, providing readers with practical guidelines for its clinical management. The first part of the book analyzes in detail the disease’s pathophysiology, its diagnostic work up as well as the prognostic stratification, and illustrates the role of genetics and gene-environment interaction. The second part presents current and future treatment options, highlighting the importance of long-term and individualized treatments and follow-up. Furthermore, it discusses open issues, such as the apparent healing phenomenon, the early prognosis of arrhythmic events or the use of genetic testing in clinical practice. Offering a multidisciplinary approach for optimizing the clinical management of DCM, this book is an invaluable aid not only for the clinical cardiologists, but for all physicians involved in the care of this challenging disease.

Author : Mahboubeh Eghbali-Webb
Publisher : Springer
Page : 142 pages
File Size : 35,31 MB
Release : 1995-01-20
Category : Medical
ISBN :

GET BOOK

This book is about the molecular and cellular biology of the collagen matrix of the heart. It is now recognized that the remodeling of the fibrillar collagen matrix that occurs under various pathophysiological conditions may adversely alter myocardial stiffness and ultimately lead to heart failure. This book begins with a comprehensive introductory chapter on the collagen matrix in general, including information on collagen types and their tissue specificity. The book then focuses on different aspects of the molecular and cellular biology of the collagen matrix in the heart, the impact of growth factors on the expression of the myocardial collagen matrix, and myocardial collagen gene regulation under pathophysiological conditions.

Author : Andrew Voorhees
Publisher :
Page : 148 pages
File Size : 12,25 MB
Release : 2014
Category :
ISBN : 9781321475173

GET BOOK

Myocardial infarction (MI) occurs when the coronary arteries that supply blood to the myocardial tissue of the heart become blocked, triggering a dynamic wound healing response and eventually leading to the formation of a collagen rich scar tissue. The properties of the collagen network that forms dictate the mechanical behavior of the infarct tissue, which in turn alters the pumping function of the left ventricle (LV). However, little is known about how variations in the collagen network alter the function of the LV and contribute to differences in patient outcome. The goal of this dissertation is to clarify the mechanisms by which variation in the structural properties of the collagen network affect the mechanical properties of the infarct tissue and the pumping function of the LV through both computational and experimental approaches. The computational approach identified that a longitudinal alignment of collagen fibers in the infarct region is able to both maximize distension of the LV during diastolic filling and the contractile force generated by the healthy regions of the LV through the Frank-Starling mechanism. The experimental approach revealed a novel mechanism to reduce LV dilation by facilitating the assembly and cross-linking of collagen fibers through deletion of the gene for matrix metalloproteinase-9. This was the first study to quantify infarct mechanical properties in mice. This work opens up new areas for potential research and the findings may lead to the development of new diagnostic and therapeutic technologies.

Author : Leon Glass
Publisher : Springer Science & Business Media
Page : 617 pages
File Size : 12,98 MB
Release : 2012-12-06
Category : Science
ISBN : 1461231183

GET BOOK

In recent years there has been a growth in interest in studying the heart from the perspective of the physical sciences: mechanics, fluid flow, electromechanics. This volume is the result of a workshop held in July 1989 at the Institute for Nonlinear Sciences at the University of California at San Diego that brought together scientists and clinicians with graduate students and postdoctoral fellows who shared an interest in the heart. The chapters were prepared by the invited speakers as didactic reviews of their subjects but also include the structure, mechanical properties, and function of the heart and the myocardium, electrical activity of the heart and myocardium, and mathematical models of heart function.

Author : Mahboubeh Eghbali-Webb
Publisher : R G Landes Company
Page : 117 pages
File Size : 37,16 MB
Release : 1995
Category : Collagen
ISBN : 9781570590702

GET BOOK

This work explores the molecular and cellular biology of the collagen matrix of the heart. Collagen is the major protein of the extracellular matrix. The extracellular matrix of the heart is an intricate network, with its importance becoming apparent to the developmental and functional integrity of the mycardium.

Author : Francisco Villarreal
Publisher : Springer Science & Business Media
Page : 398 pages
File Size : 46,32 MB
Release : 2005
Category : Medical
ISBN : 9780387228242

GET BOOK

Interstitial Fibrosis in Heart Failure, edited by Francisco J. Villarreal, M.D., Ph.D., provides a timely and integrative review of the basics of cardiac extracellular matrix structure. Topics covered include how cardiac remodeling influences its disposition, abundance and function; possible non-invasive techniques for diagnosis; and potential drug-based or molecular therapeutic strategies that may interrupt or even reverse the course of the development of cardiac fibrosis. This resource for both clinicians and scientists aims to cover state-of-the-art findings relevant to cellular and molecular processes underlying cardiac fibrosis including basic elements of structure, function, diagnosis and treatment.