[PDF] Conformational Proteomics Of Macromolecular Architecture Approaching The Structure Of Large Molecular Assemblies And Their Mechanisms Of Action With Cd Rom eBook

Author : R Holland Cheng
Publisher : World Scientific
Page : 433 pages
File Size : 17,21 MB
Release : 2004-06-21
Category : Science
ISBN : 9814483966

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Biological processes involving large macromolecular assemblies are thought to be a dynamic consequence of cooperativity and metastability. The folding of a peptide chain creates local environments from which “activity” can emerge. In the same way, the assembly of large molecular complexes creates dynamic features that would only be feasible in a large construct. The biological implications of such adaptation are explored as it applies to the static quasisymmetry situations, as well as to the dynamics of structural transitions. The current wealth of solved high-resolution complex structures makes this an appropriate time to summarize the state of the art in structural dynamics of living architectures. With contributions by leading scientists in the fields of virology, bacterial flagellum, cytoskeleton, ribosome and giant enzymes, this important book presents cutting-edge knowledge in the various fields of structural proteomics of very large molecular assemblies, with the focus on their mechanisms of action.

Author : R. Holland Cheng
Publisher : World Scientific
Page : 440 pages
File Size : 14,42 MB
Release : 2004
Category : Science
ISBN : 9789812386151

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Electronic version of the text of the same title with additional audio and video links.

Author : Wayne L. Mattice
Publisher : Wiley-Interscience
Page : 480 pages
File Size : 33,60 MB
Release : 1994-11-04
Category : Science
ISBN :

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Ubiquitous computers, coupled with software packages for the visualization and manipulation of atom-based polymer models, also contribute to increased use of the technique.

Author : J. Robin Harris
Publisher : Springer Nature
Page : 580 pages
File Size : 42,17 MB
Release : 2020-11-30
Category : Science
ISBN : 3030589714

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This book covers important topics such as the dynamic structure and function of the 26S proteasome, the DNA replication machine: structure and dynamic function and the structural organization and protein–protein interactions in the human adenovirus capsid, to mention but a few. The 18 chapters included here, written by experts in their specific field, are at the forefront of scientific knowledge. The impressive integration of structural data from X-ray crystallography with that from cryo-electron microscopy is apparent throughout the book. In addition, functional aspects are also given a high priority. Chapter 1 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Author : A. J. Hopfinger
Publisher :
Page : 360 pages
File Size : 16,7 MB
Release : 1973
Category : Science
ISBN :

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Conformational Properties of Macromolecules ...

Author : Joel Sussman
Publisher : World Scientific
Page : 597 pages
File Size : 49,83 MB
Release : 2008
Category : Science
ISBN : 9812772049

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Ranging from policy issues related to funding and goals, through high-throughput procedures for protein production, this text presents an overview of structural proteomics via a multidisciplinary approach involving molecular biology.

Author : Ke-li Han
Publisher : Springer
Page : 0 pages
File Size : 29,41 MB
Release : 2016-08-27
Category : Medical
ISBN : 9783319353890

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This book discusses how biological molecules exert their function and regulate biological processes, with a clear focus on how conformational dynamics of proteins are critical in this respect. In the last decade, the advancements in computational biology, nuclear magnetic resonance including paramagnetic relaxation enhancement, and fluorescence-based ensemble/single-molecule techniques have shown that biological molecules (proteins, DNAs and RNAs) fluctuate under equilibrium conditions. The conformational and energetic spaces that these fluctuations explore likely contain active conformations that are critical for their function. More interestingly, these fluctuations can respond actively to external cues, which introduces layers of tight regulation on the biological processes that they dictate. A growing number of studies have suggested that conformational dynamics of proteins govern their role in regulating biological functions, examples of this regulation can be found in signal transduction, molecular recognition, apoptosis, protein / ion / other molecules translocation and gene expression. On the experimental side, the technical advances have offered deep insights into the conformational motions of a number of proteins. These studies greatly enrich our knowledge of the interplay between structure and function. On the theoretical side, novel approaches and detailed computational simulations have provided powerful tools in the study of enzyme catalysis, protein / drug design, protein / ion / other molecule translocation and protein folding/aggregation, to name but a few. This work contains detailed information, not only on the conformational motions of biological systems, but also on the potential governing forces of conformational dynamics (transient interactions, chemical and physical origins, thermodynamic properties). New developments in computational simulations will greatly enhance our understanding of how these molecules function in various biological events.

Author : Raymond J. Owens
Publisher : Humana Press
Page : 0 pages
File Size : 14,81 MB
Release : 2014-12-11
Category : Science
ISBN : 9781493922291

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This updated and expanded volume reflects the current state of the structural protein field with improved and refined protocols that have been applied to particularly challenging proteins, notably integral membrane proteins and multi-protein complexes. Structural Proteomics: High-Throughput Methods, Second Edition begins by exploring the resources available for curation, annotation, and structure prediction in silico, and continues with methods for sample preparation of both proteins and crystals, as well as structural characterization techniques. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and up-to-date, Structural Proteomics: High-Throughput Methods, Second Edition will aid researchers in expanding our knowledge of this vital and expansive area of protein science.

Author : Martin Karplus
Publisher : World Scientific
Page : 313 pages
File Size : 33,6 MB
Release : 2020-06-22
Category : Science
ISBN : 1786348047

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'Karplus's tales of a turbulent graduate school experience at Caltech will inspire readers to muster fortitude when everything seems to be spinning out of control. Karplus balances rigorous scientific discussions with refreshing chapters expounding his passion for photography and gastronomy.'Nature Chemistry, May 2020Nobel Laureate Martin Karplus was eight when his family fled Nazi-occupied Austria via Switzerland and France for the United States. He would later credit his life as a refugee as a decisive influence on his world view and approach to science.Spinach on the Ceiling is an autobiographical telling of Karplus' life story, and how it led him to win the Nobel Prize in Chemistry in 2013. The book captures pivotal moments in Martin's life — from his escape to Switzerland in 1938 shortly after Hitler's entrance into Austria; to memorable moments like when his parents gave him a microscope which opened his eyes to the wonders of science; to his education in New England and California; and his eventual scientific career which took him to England, Illinois, Columbia, Strasbourg, and Harvard. It relates how Martin's optimistic outlook and belief in his vision made it possible for him to overcome setbacks in his life, and turn a subject of study his colleagues considered a waste of time into a central part of chemistry and structural biology. It is his hope to inspire and aid young readers, in particular, to have a successful trajectory in their own lives. Although research and teaching have been his primary focus, he has traveled the world photographing people and places with a Leica IIIC and has had numerous exhibitions of the photographs. He has also enjoyed a lifelong interest in cooking and worked in some of the best restaurants in France and Spain.

Author : Jennifer J. McManus
Publisher : Humana
Page : 266 pages
File Size : 27,61 MB
Release : 2020-08-08
Category : Science
ISBN : 9781493996803

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This volume explores experimental and computational approaches to measuring the most widely studied protein assemblies, including condensed liquid phases, aggregates, and crystals. The chapters in this book are organized into three parts: Part One looks at the techniques used to measure protein-protein interactions and equilibrium protein phases in dilute and concentrated protein solutions; Part Two describes methods to measure kinetics of aggregation and to characterize the assembled state; and Part Three details several different computational approaches that are currently used to help researchers understand protein self-assembly. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, Protein Self-Assembly: Methods and Protocols is a valuable resource for researchers who are interested in learning more about this developing field.