[PDF] Confermation Of Biological Macromolecules eBook

Author : Amit Kumar Nayak
Publisher : Academic Press
Page : 673 pages
File Size : 44,29 MB
Release : 2021-11-23
Category : Science
ISBN : 0323856381

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Biological Macromolecules: Bioactivity and Biomedical Applications presents a comprehensive study of biomacromolecules and their potential use in various biomedical applications. Consisting of four sections, the book begins with an overview of the key sources, properties and functions of biomacromolecules, covering the foundational knowledge required for study on the topic. It then progresses to a discussion of the various bioactive components of biomacromolecules. Individual chapters explore a range of potential bioactivities, considering the use of biomacromolecules as nutraceuticals, antioxidants, antimicrobials, anticancer agents, and antidiabetics, among others. The third section of the book focuses on specific applications of biomacromolecules, ranging from drug delivery and wound management to tissue engineering and enzyme immobilization. This focus on the various practical uses of biological macromolecules provide an interdisciplinary assessment of their function in practice. The final section explores the key challenges and future perspectives on biological macromolecules in biomedicine. Covers a variety of different biomacromolecules, including carbohydrates, lipids, proteins, and nucleic acids in plants, fungi, animals, and microbiological resources Discusses a range of applicable areas where biomacromolecules play a significant role, such as drug delivery, wound management, and regenerative medicine Includes a detailed overview of biomacromolecule bioactivity and properties Features chapters on research challenges, evolving applications, and future perspectives

Author : G. Govil
Publisher : Springer Science & Business Media
Page : 226 pages
File Size : 44,23 MB
Release : 2012-12-06
Category : Science
ISBN : 3642680976

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The determination of the three-dimensional structure of a biological molecule is the starting point in the understanding of molecular mechanisms involved in its complex biochemical reactions. The molecular architecture of multimolecular systems such as membranes and chromosomes provides the key to the fascinating field of molecular biology. Stereochemical details of biological macromolecules and their interactions with pharmacological agents form the basis for drug design. Naturally, the study of the structure and function of biological molecules has aroused tremendous interest and investigations in this area are being carried out in a large number of laboratories. The techniques used for this purpose include both experimental methods (X-ray and neutron diffraction measurements, study of NMR, ESR, vibrational and electronic spectra, ORD, CD and dipole moment measurements, biochemical modifications etc. ) and the oretical methods (quantum mechanical and classical potential energy calculations, Monte Carlo simulations and molecular graphics). F or several years now, X-ray diffraction [1] has served as our only source of infor mation on the three-dimensional arrangements of atoms in biopolymers. Fiber-diffrac tion of DNA led to the proposal of the DNA double helix. Fibers of long~hain polymers show ordering in the direction of the fibre-axis but not in the transverse plane. Accurate estimates of the dimensions of helical structures can be made using techniques on the basis of which models of biopolymers can be constructed.

Author : Oleg Jardetzky
Publisher : Springer Science & Business Media
Page : 308 pages
File Size : 46,66 MB
Release : 2012-12-06
Category : Science
ISBN : 1461558395

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From within complex structures of organisms and cells down to the molecular level, biological processes all involve movement. Muscular fibers slide on each other to activate the muscle, as polymerases do along nucleic acids for replicating and transcribing the genetic material. Cells move and organize themselves into organs by recognizing each other through macromolecular surface-specific interactions. These recognition processes involve the mu tual adaptation of structures that rely on their flexibility. All sorts of conformational changes occur in proteins involved in through-membrane signal transmission, showing another aspect of the flexibility of these macromolecules. The movement and flexibility are inscribed in the polymeric nature of essential biological macromolecules such as proteins and nucleic acids. For instance, the well-defined structures formed by the long protein chain are held together by weak noncovalent interac tions that design a complex potential well in which the protein floats, permanently fluctuating between several micro- or macroconformations in a wide range of frequencies and ampli tudes. The inherent mobility of biomolecular edifices may be crucial to the adaptation of their structures to particular functions. Progress in methods for investigating macromolecular structures and dynamics make this hypothesis not only attractive but more and more testable.

Author : Jo M. Holt
Publisher : Elsevier
Page : 315 pages
File Size : 39,28 MB
Release : 2004-04-02
Category : Science
ISBN : 0080497179

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This volume focuses on the cooperative binding aspects of energetics in biological macromolecules. Methodologies such as NMR, small-angle scattering techniques for analysis, calorimetric analysis, fluorescence quenching, and time resolved FRET measurements are discussed. *Methods for Evaluating Cooperativity in a Dimeric Hemoglobin*Multiple-Binding of Ligands to a Linear Biopolymer*Fluorescence Quenching Methods to Study Protein-Nucleic Acid Interactions*Linked Equilibria in Biotin Repressor Function: Thermodynamic, Structural and Kinetic Analysis

Author : Finn Wold
Publisher : Prentice Hall
Page : 328 pages
File Size : 47,79 MB
Release : 1971
Category : Science
ISBN :

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In this book we discuss the status of the structure- function analysis of biological macromolecules and macromolecular complexes. The ultimate goal of the analysis must be to explain all the functional properties of the molecules in question in terms of their completely defined three-dimensional structure, and the analysis thus contains three separate components: the determination of structure, the determination and quantitation of function, and final correlation of this information into the structure-function model. The first component, the structural analysis, is reviewed only briefly, and this book therefore leans heavily on Barker's and Van Holde's books in this series for proper background and documentation for this component. The second component, the analysis of functional properties, is given broader consideration (Chapters I, 2, 5, and 9), but the main emphasis has been the step-by-step development of the structure-function models. It is hoped that this approach will clearly illustrate the typical progression of scientific model building from the first clear definition of the problem and the statement of the hypothesis through ever-increasing refinements of experimental tests toward the final answer. It is also hoped that the statements of philosophy, principles, and scientific method that are the bases for this approach are of broad enough validity to survive even after its models have become obsolete. With this approach, it is essential to inform the reader in unequivocal terms that this book is not a summary of final conclusions and complete stories which can be submitted to memory. Each system discussed should be considered very critically, and the models should be evaluated in terms of the available evidence. The only "facts" are the experimental data; the interpretation of this data into models is only convincing to the extent that it makes logical sense to the individual examining it. Since both space and common sense prohibits a continuous reiteration of this statement throughout the book, be prepared to encounter some models and hypotheses which are based on sound experimental evidence as well as some which have no experimental basis at all. In neither case are they "facts," but in either case they represent ideas which can be subjected to further experimental tests. If the book helps to sharpen this critical evaluation of both ideas and the experimental test of the hypotheses, one of its major purposes has been fulfilled.

Author : Oleg Jardetzky
Publisher : IOS Press
Page : 212 pages
File Size : 14,67 MB
Release : 2001
Category : Biomolecules
ISBN : 9781586030322

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A collection of articles looking at modern structural biology, summarizing the applications of physical methods - such as x-ray diffraction, high resolution nuclear magnetic resonance and molecular dynamics - to the study of protein structure and dynamics. There is a review of contemporary thoughts within the field, looking at the mechanisms of alloateric transitions and allosteric control, the transmission of information within protein structures and the role of dynamics in determining the specificity of protein - ligand interactions. There is also a look at future innovations.

Author : Westhof
Publisher : CRC Press
Page : 488 pages
File Size : 31,57 MB
Release : 1993-08-16
Category : Medical
ISBN :

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Water structure. Termadynamic and dynamic properties of water. Hydratyon of amino acids in protein crystals. Water structure of crystallized proteins: high-resolution studies. Hydration of proteins secondary structures-the role in protein folding. Molecular dynamics simulations on the hydration, structure and motions of DNA oligomers. Structural water bridges in nucleic acids. Hydration sites and hydration bridges around DNA helices. Light scattering spectroscopy studies of the water molecules in DNA. Polysacaride interactions with water. The role of structural water molecules in protein-sccharide complexes. Lipid hydration. Hydration forces. Solvation thermodynamics of biopolymers.