[PDF] Computational Drug Discovery eBook

Author : D. C. Young
Publisher : John Wiley & Sons
Page : 344 pages
File Size : 32,59 MB
Release : 2009-01-28
Category : Science
ISBN : 9780470451847

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Helps you choose the right computational tools and techniques to meet your drug design goals Computational Drug Design covers all of the major computational drug design techniques in use today, focusing on the process that pharmaceutical chemists employ to design a new drug molecule. The discussions of which computational tools to use and when and how to use them are all based on typical pharmaceutical industry drug design processes. Following an introduction, the book is divided into three parts: Part One, The Drug Design Process, sets forth a variety of design processes suitable for a number of different drug development scenarios and drug targets. The author demonstrates how computational techniques are typically used during the design process, helping readers choose the best computational tools to meet their goals. Part Two, Computational Tools and Techniques, offers a series of chapters, each one dedicated to a single computational technique. Readers discover the strengths and weaknesses of each technique. Moreover, the book tabulates comparative accuracy studies, giving readers an unbiased comparison of all the available techniques. Part Three, Related Topics, addresses new, emerging, and complementary technologies, including bioinformatics, simulations at the cellular and organ level, synthesis route prediction, proteomics, and prodrug approaches. The book's accompanying CD-ROM, a special feature, offers graphics of the molecular structures and dynamic reactions discussed in the book as well as demos from computational drug design software companies. Computational Drug Design is ideal for both students and professionals in drug design, helping them choose and take full advantage of the best computational tools available. Note: CD-ROM/DVD and other supplementary materials are not included as part of eBook file.

Author : Riccardo Baron
Publisher : Humana Press
Page : 0 pages
File Size : 38,80 MB
Release : 2011-12-21
Category : Medical
ISBN : 9781617794643

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Due to the rapid and steady growth of available low-cost computer power, the use of computers for discovering and designing new drugs is becoming a central topic in modern molecular biology and medicinal chemistry. In Computational Drug Discovery and Design: Methods and Protocols expert researchers in the field provide key techniques to investigate biomedical applications for drug developments based on computational chemistry. These include methods and techniques from binding sites prediction to the accurate inclusion of solvent and entropic effects, from high-throughput screening of large compound databases to the expanding area of protein-protein inhibition, toward quantitative free-energy approaches in ensemble-based drug design using distributed computing. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, reference to software and open source analysis tools, step-by-step, readily reproducible computational protocols, and key tips on troubleshooting and avoiding known pitfalls. Thorough and intuitive, Computational Drug Discovery and Design: Methods and Protocols aids scientists in the continuing study of state-of-the-art concepts and computer-based methodologies.

Author : Anil Kumar Saxena
Publisher : Springer Nature
Page : 405 pages
File Size : 21,7 MB
Release : 2021-10-18
Category : Science
ISBN : 3030852814

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This book reviews recent physicochemical and biophysical techniques applied in drug discovery research, and it outlines the latest advances in computational drug design. Divided into 10 chapters, the book discusses about the role of structural biology in drug discovery, and offers useful application cases of several biophysical and computational methods, including time-resolved fluorometry (TRF) with Förster resonance energy transfer (FRET), X-Ray crystallography, nuclear magnetic resonance spectroscopy, mass spectroscopy, generative machine learning for inverse molecular design, quantum mechanics/molecular mechanics (QM/MM,ONIOM) and quantum molecular dynamics (QMT) methods. Particular attention is given to computational search techniques applied to peptide vaccines using novel mathematical descriptors and structure and ligand-based virtual screening techniques in drug discovery research. Given its scope, the book is a valuable resource for students, researchers and professionals from pharmaceutical industry interested in drug design and discovery.

Author : Patrick Bultinck
Publisher : CRC Press
Page : 844 pages
File Size : 19,2 MB
Release : 2003-12-17
Category : Medical
ISBN : 9780203913390

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Observing computational chemistry's proven value to the introduction of new medicines, Computational Medicinal Chemistry for Drug Discovery offers the techniques most frequently utilized by industry and academia for ligand design. Featuring contributions from more than 50 preeminent scientists, this book surveys molecular structure computation, intermolecular behavior, ligand-receptor interaction, and modeling. It also examines molecular mechanics, semi-empirical methods, wave function-based quantum chemistry, density functional theory, 3-D structure generation, and hybrid methods.

Author : Dev Bukhsh Singh
Publisher : Springer Nature
Page : 308 pages
File Size : 24,6 MB
Release : 2020-10-09
Category : Medical
ISBN : 9811568154

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This book provides up-to-date information on bioinformatics tools for the discovery and development of new drug molecules. It discusses a range of computational applications, including three-dimensional modeling of protein structures, protein-ligand docking, and molecular dynamics simulation of protein-ligand complexes for identifying desirable drug candidates. It also explores computational approaches for identifying potential drug targets and for pharmacophore modeling. Moreover, it presents structure- and ligand-based drug design tools to optimize known drugs and guide the design of new molecules. The book also describes methods for identifying small-molecule binding pockets in proteins, and summarizes the databases used to explore the essential properties of drugs, drug-like small molecules and their targets. In addition, the book highlights various tools to predict the absorption, distribution, metabolism, excretion (ADME) and toxicity (T) of potential drug candidates. Lastly, it reviews in silico tools that can facilitate vaccine design and discusses their limitations.

Author : Marco Tutone
Publisher :
Page : 387 pages
File Size : 10,43 MB
Release : 2021
Category :
ISBN : 9783036527789

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This book is a collection of original research articles in the field of computer-aided drug design. It reports the use of current and validated computational approaches applied to drug discovery as well as the development of new computational tools to identify new and more potent drugs.

Author : Robert M. Stroud
Publisher : Royal Society of Chemistry
Page : 171 pages
File Size : 45,92 MB
Release : 2008
Category : Medical
ISBN : 0854043659

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This insightful book represents the experience and understanding of the global experts in the field and spotlights both the structural and medicinal chemistry aspects of drug design. The need to 'encode' the physiological factors of pharmacology, a key area, is explored.

Author : William T. Loging
Publisher : Cambridge University Press
Page : 255 pages
File Size : 15,61 MB
Release : 2016-03-17
Category : Computers
ISBN : 0521768004

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A comprehensive overview of the use of computational biology approaches in the drug discovery and development process.

Author : Alexander Heifetz
Publisher : Humana Press
Page : 436 pages
File Size : 11,67 MB
Release : 2017-11-30
Category : Medical
ISBN : 9781493974641

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This volume looks at modern computational strategies and techniques used in GPCR drug discovery including structure and ligand-based approaches and cheminformatics. The chapters in this book describe how these approaches can be applied to address key drug discovery issues, such as receptor structure modelling, function and dynamics, prediction of protein-water-ligand interactions and binding kinetics, free energy of binding, interconversion between agonists and antagonists, deorphanization of GPCRs, and the discovery of biased and allosteric modulators. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary software and tools, step-by-step, readily reproducible modelling protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and unique,Computational Methods for GPCR Drug Discovery is a valuable resource for structural and molecular biologists, computational and medicinal chemists, pharmacologists, and drug designers.

Author : Prof Mohammed
Publisher : Biocuration Labs
Page : 36 pages
File Size : 38,45 MB
Release : 2015-09-05
Category : Medical
ISBN : 1517184851

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This book has originated from Practical class on Genomics & Proteomics that are offered to students of Computational Biology, Bangalore University of Bangalore. The idea to write a book on Computational Biology was born during the preparations of these practical where I realized that it is extremely difficult to achieve an overview of the area of Drug Discovery and to follow the progress of this field. This is the first book in 2015 and was written in English .Computational Biology is a major topic in modern medical, Life science and pharmacological research and is of central importance in the computational biology science. Accordingly, The enormous increase in data on Drug Designing has led me to leave out the practical on Computational Biology and. This topic has since evolved into a huge research area of its own that could not be considered adequately within this book. My knowledge of Drug Designing practical has exploded in the past 5 years, Bioinformatics could be treated here with the same thoroughness. It is the aim of the present book to describe the Bioinformatics practical approach for life science students.