[PDF] Clinical Bioenergetics eBook

Author : Sergej M. Ostojic
Publisher : Academic Press
Page : 720 pages
File Size : 44,27 MB
Release : 2020-11-12
Category : Science
ISBN : 0128227729

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Clinical Bioenergetics: From Pathophysiology to Clinical Translation provides recent developments surrounding the etiology and pathophysiology of inherited and acquired energy-delated disorders. Across 40 chapters, world leaders in bioenergetics and mitochondrial medicine discuss novel methodologies designed to identify deficiencies in cellular bioenergetics, as well as the safety and efficacy of emerging management strategies to address poor cellular bioenergetics. Topics discussed include the omics landscape of impaired mitochondrial bioenergetics, hormones, tissue bioenergetics and metabolism in humans. Disease-specific case studies, modes of analysis in clinical bioenergetics, and therapeutic opportunities for impaired bioenergetics, addressing both known treatment pathways and future directions for research, are discussed in-depth. Diseases and Disorders examined include brain injury, chronic fatigue syndrome, psychiatric disorders, pulmonary fibrosis, neurodegenerative disorders, heart failure, chronic kidney disease, obesity, and insulin resistance, among others. Provides a thorough discussion of foundational aspects of bioenergetics and disease, modes of analysis, and treatments for impaired bioenergetics Discusses the role of bioenergetics and treatment pathways in brain injury, chronic fatigue syndrome, psychiatric disorders, pulmonary fibrosis, neurodegenerative disorders, heart failure, chronic kidney disease, obesity, and insulin resistance, among other diseases and disorders Features chapter contributions from international leaders in translational bioenergetics research and clinical practice

Author : David G. Nicholls
Publisher : Academic Press
Page : 434 pages
File Size : 13,88 MB
Release : 2013-05-20
Category : Science
ISBN : 0123884314

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Extensively revised, the fourth edition of this highly successful book takes into account the many newly determined protein structures that provide molecular insight into chemiosmotic energy transduction, as well as reviewing the explosive advances in 'mitochondrial physiology'-the role of the mitochondria in the life and death of the cell. Covering mitochondria, bacteria and chloroplasts, the fourth edition of Bioenergetics provides a clear and comprehensive account of the chemiosmotic theory and its many applications. The figures have been carefully designed to be memorable and to convey the key functional and mechanistic information. Written for students and researchers alike, Bioenergetics is the most well-known, current and respected text on chemiosmotic theory and membrane bioenergetics available. BMA Medical Book Awards 2014-Highly Commended, Basic and Clinical Sciences,2014,British Medical Association Chapters are now divided between three interlocking sections: basic principles, structures and mechanisms, and mitochondrial physiology Covers new advances in the structure and mechanism of key bioenergetic proteins, including complex I of the respiratory chain and transport proteins Details cellular bioenergetics, mitochondrial cell biology and signal transduction, and the roles of mitochondria in physiology, disease and aging Offers readers clear, visual representation of structural concepts through full colour figures throughout the book

Author : Jie Kang
Publisher : Human Kinetics
Page : 232 pages
File Size : 18,73 MB
Release : 2008
Category : Medical
ISBN : 9780736062411

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"More in-depth than cursory discussions found in exercise physiology texts and more practical and accessible than dedicated bioenergetics texts, Bioenergetics Primer for Exercise Science encompasses all the up-to-date research and information regarding human bioenergetics and energy metabolism. It offers both students and professionals a depth of knowledge that will inform their further study, research, and profession."--Jacket.

Author : Vladimir P. Skulachev
Publisher : Springer Science & Business Media
Page : 435 pages
File Size : 29,89 MB
Release : 2012-12-15
Category : Science
ISBN : 364233430X

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Principles of Bioenergetics summarizes one of the quickly growing branches of modern biochemistry. Bioenergetics concerns energy transductions occurring in living systems and this book pays special attention to molecular mechanisms of these processes. The main subject of the book is the "energy coupling membrane" which refers to inner membranes of intracellular organelles, for example, mitochondria and chloroplasts. Cellular cytoplasmic membranes where respiratory and photosynthetic energy transducers, as well as ion-transporting ATP-synthases (ATPases) are also part of this membrane. Significant attention is paid to the alternative function of mitochondria as generators of reactive oxygen species (ROS) that mediate programmed death of cells (apoptosis and necrosis) and organisms (phenoptosis). The latter process is considered as a key mechanism of aging which may be suppressed by mitochondria-targeted antioxidants.

Author : D. A. Harris
Publisher : John Wiley & Sons
Page : 120 pages
File Size : 33,24 MB
Release : 2009-06-29
Category : Science
ISBN : 1444313770

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Bioenergetics is the study of the way biological systems, usually at the molecular level, utilize and convert energy in order to drive the biochemical reactions that constitute life. However, because of its often quantitative basis and the amount of technical jargon, the subject tends to alienate and intimidate students. This beautifully illustrated text has a lucid and logical approach to the subject. The text uses the modern perspective throughout so that the student is given an easily assimilable, logical introduction to the important concepts of the subject, particulary the core concept, the 'chemiosmotic theory'. It has been specifically designed to make information easily accessible by devoting each double-page spread to one topic. Within the spread, a variety of carefully constructed diagrams present information in a concise and innovative manner. The text is further enhanced by a comprehensive guide to additional reading. Original, easily understood combination of visual and written information. 43 double-page speads give a clear and concise introduction to this traditionally difficult subject. The most up to date text available, covering all modern molecular genetic techniques. Competitively priced.

Author : David G. Nicholls
Publisher : Gulf Professional Publishing
Page : 334 pages
File Size : 39,79 MB
Release : 2002
Category : Nature
ISBN : 9780125181211

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Revised and updated to include the many developments that have taken place in bioenergetics, this text covers the structures of key membrane proteins involved in bioenergetics and mitochondrial physiology.

Author : S. Papa
Publisher : Springer Science & Business Media
Page : 827 pages
File Size : 30,82 MB
Release : 2012-12-06
Category : Science
ISBN : 1461548438

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1. The Mitochondrial and Bacterial Respiratory Chains: From MacMunn and Keilin to Current Concepts; P. Nicholls. 2. The Mitochondrial Enzymes of Oxidative Phosphorylation; Y. Hatefi. 3. Proton Pumps of Respiratory Chain Enzymes; S. Papa, et al. 4. Uncoupling of Respiration and Phosphorylation; V.P. Skulachev. 5. Crystallization, Structure, and Possible Mechanism of Action of Cytochrome c Oxidase from the Soil Bacterium Paracoccus denitrificans; M. Hartmut, et al. 6. The Structure of Crystalline Bovine Heart Cytochrome c Oxidase; S. Yoshikawa, et al. 7. Electron and Proton Transfer in.

Author : Chong H. Kim
Publisher : Springer Science & Business Media
Page : 468 pages
File Size : 32,16 MB
Release : 2012-12-06
Category : Science
ISBN : 1468458353

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The emergence of the Biochemical Sciences is underlined by the FAOB symposium in Seoul and highlighted by this Satellite meeting on the "New Bioenergetics. " Classical mitochondrial electron transfer and energy coupling is now complemented by the emerging molecular biology of the respiratory chain which is studied hand in hand with the recognition of mitochondrial disease as a major and emerging study in the basic and clinical medical sciences. Thus, this symposium has achieved an important balance of the fundamental and applied aspects of bioenergetics in the modern setting of molecular biology and mitochondrial disease. At the same time, the symposium takes note not only of the emerging excellence of Biochemical Studies in the Orient and indeed in Korea itself, but also retrospectively enjoys the history of electron transport and energy conservation as represented by the triumvirate ofYagi, King and Slater. Many thanks are due Drs. Kim and Ozawa for their elegant organization of this meeting and its juxtaposition to the FAOB Congress. Britton Chance April 2, 1990 v PREFACE This book contains the contributed papers presented at the "International Symposium on Bioenergetics: Molecular Biology, Biochemistry and Pathology", held in Seoul, Korea, August 18-21, 1989, sponsored by International Union of Biochemistry (as ruB Symposium No. 191) and Ewha Womans University, Seoul, Korea. The symposium was held in honor of Professor Kunio Yagi to commemorate his 70th birthday.