[PDF] Chromatographic Methods In Metabolomics eBook

Author : Tuulia Hyotylainen
Publisher : Royal Society of Chemistry
Page : 259 pages
File Size : 46,10 MB
Release : 2013-09-06
Category : Science
ISBN : 1849737274

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The concept of a metabolic profile was introduced in 1971, when gas chromatography demonstrated a range of compounds present in human samples. Now termed metabolomics, the field is still emerging, and chromatography remains an essential tool for determining metabolites in a living system. This is the first book to present the chromatographic techniques used in metabolomics in a fundamental way. Sample preparation and quality control are described in detail, and all forms of chromatography applied to metabolomics are included. The editors present guidelines on selecting the most appropriate methodology, making the book an accessible guide to anyone entering the field. Handling data and applications are also described. This is an essential handbook for any laboratory looking to embark on a metabolomics research programme and includes the fundamentals of chromatography alongside the latest developments in the field.

Author : Tuulia Hyotylainen
Publisher : Royal Society of Chemistry
Page : 258 pages
File Size : 35,27 MB
Release : 2013
Category : Science
ISBN : 1849736073

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Intends to present chromatographic techniques in metabolomics in a fundamental way. This book covers the chromatographic techniques, such as liquid chromatography, gas chromatography, comprehensive two-dimensional gas chromatography and electrochromatographic techniques utilised in metabolomics.

Author : Wolfram Weckwerth
Publisher : Springer Science & Business Media
Page : 290 pages
File Size : 14,93 MB
Release : 2008-02-04
Category : Science
ISBN : 1597452440

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Metabolomics: Methods and Protocols examines the state-of-the-art in metabolomic analysis. Leading researchers in the field present protocols for the application of complementary analytical methods, such as gas chromatography-mass spectrometry (GC-MS). Metabolomics: Methods and Protocols contains forward-looking protocols, which provide the essential groundwork for future efforts in elucidating the structure of the unknowns detected in metabolomic studies.

Author : Rawi Ramautar
Publisher : Royal Society of Chemistry
Page : 367 pages
File Size : 22,6 MB
Release : 2021-07-21
Category : Science
ISBN : 1839161639

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Discussing the state-of-the-art of the proposed topics in one single book for probing the polar metabolome, using relevant examples, is unique and needed in the metabolomics field.

Author : Kazuki Saito
Publisher : Springer Science & Business Media
Page : 351 pages
File Size : 18,31 MB
Release : 2006-06-29
Category : Science
ISBN : 3540297820

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Metabolomics – which deals with all metabolites of an organism – is a rapidly-emerging sector of post-genome research fields. It plays significant roles in a variety of fields from medicine to agriculture and holds a fundamental position in functional genomics studies and their application in plant biotechnology. This volume comprehensively covers plant metabolomics for the first time. The chapters offer cutting-edge information on analytical technology, bioinformatics and applications. They were all written by leading researchers who have been directly involved in plant metabolomics research throughout the world. Up-to-date information and future developments are described, thereby producing a volume which is a landmark of plant metabolomics research and a beneficial guideline to graduate students and researchers in academia, industry, and technology transfer organizations in all plant science fields.

Author : Paul L. Wood
Publisher : Humana
Page : 307 pages
File Size : 37,9 MB
Release : 2021-11-15
Category : Medical
ISBN : 9781071608661

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This volume discusses the latest analytical approaches used to sample defined molecular populations of metabolites via functional group derivatization, specialized chromatographic methods, and ionization techniques. Chapters cover key methods for sample introductions to the ion source, including direct flow, gas chromatography, liquid chromatography, and capillary electrophoresis. Chapters also explore non-targeted and targeted analyses, as well as the emerging field of metallomics. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and authoritative, Metabolomics is a valuable resource for students, researchers, practicing physicians and veterinarians, and administrators involved in the funding of research.

Author : Julia Kuligowski
Publisher : MDPI
Page : 206 pages
File Size : 32,27 MB
Release : 2021-04-07
Category : Medical
ISBN : 3039438131

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Metabolomics is increasingly being used to explore the dynamic responses of living systems in biochemical research. The complexity of the metabolome is outstanding, requiring the use of complementary analytical platforms and methods for its quantitative or qualitative profiling. In alignment with the selected analytical approach and the study aim, sample collection and preparation are critical steps that must be carefully selected and optimized to generate high-quality metabolomic data. This book showcases some of the most recent developments in the field of sample preparation for metabolomics studies. Novel technologies presented include electromembrane extraction of polar metabolites from plasma samples and guidelines for the preparation of biospecimens for the analysis with high-resolution μ magic-angle spinning nuclear magnetic resonance (HR-μMAS NMR). In the following chapters, the spotlight is on sample preparation approaches that have been optimized for diverse bioanalytical applications, including the analysis of cell lines, bacteria, single spheroids, extracellular vesicles, human milk, plant natural products and forest trees.

Author : Silas G. Villas-Boas
Publisher : John Wiley & Sons
Page : 339 pages
File Size : 15,95 MB
Release : 2007-02-16
Category : Science
ISBN : 047010550X

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Providing information on the main approaches for the analysis of metabolites, this textbook: Covers basic methodologies in sample preparation and separation techniques, as well as the most recent techniques of mass spectrometry. Differentiates between primary and secondary metabolites. Includes four chapters discussing successful metabolome studies of different organisms. Highlights the analytical challenges of studying metabolites. Illustrates applications of metabolome analysis through the use of case studies.

Author : Paul L. Wood
Publisher :
Page : pages
File Size : 26,9 MB
Release : 2021
Category : Metabolites
ISBN : 9781071608647

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This volume discusses the latest analytical approaches used to sample defined molecular populations of metabolites via functional group derivatization, specialized chromatographic methods, and ionization techniques. Chapters cover key methods for sample introductions to the ion source, including direct flow, gas chromatography, liquid chromatography, and capillary electrophoresis. Chapters also explore non-targeted and targeted analyses, as well as the emerging field of metallomics. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and authoritative, Metabolomics is a valuable resource for students, researchers, practicing physicians and veterinarians, and administrators involved in the funding of research.

Author : Xinghua Guo
Publisher : BoD – Books on Demand
Page : 226 pages
File Size : 22,16 MB
Release : 2014-02-26
Category : Science
ISBN : 9535112279

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For decades gas chromatography has been and will remain an irreplaceable analytical technique in many research areas for both quantitative analysis and qualitative characterization/identification, which is still supplementary with HPLC. This book highlights a few areas where significant advances have been reported recently and/or a revisit of basic concepts is deserved. It provides an overview of instrumental developments, frontline and modern research as well as practical industrial applications. The topics include GC-based metabolomics in biomedical, plant and microbial research, natural products as well as characterization of aging of synthetic materials and industrial monitoring, which are contributions of several experts from different disciplines. It also contains best hand-on practices of sample preparation (derivatization) and data processing in daily research. This book is recommended to both basic and experienced researchers in gas chromatography.