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Author : International Cholinergic Symposium
Publisher :
Page : 378 pages
File Size : 42,23 MB
Release : 1996
Category : Acetylcholine
ISBN : 9780444801043
Author : Giancarlo Pepeu
Publisher : Springer Science & Business Media
Page : 964 pages
File Size : 10,67 MB
Release : 2013-03-08
Category : Science
ISBN : 1468486438
Every three years early Spring witnesses the convening of a small group of neuroscientists from many parts of the world. They are devoted to the study of acetylcholine, the oldest of the known neurotransmitters. To assess the level of knowledge, to take stock of the still unsolved problems, to evaluate the practical meaning of their findings, the cholinologists first met in 1969 in the eerie atmosphere of a snow-covered Swedish forest, the second in the Swiss Alps, the third facing the surf and foam of the Paci fic waves. Finally in March 1980 Florence, her trees burgeoning in the mild rain of March, confronted them with the temptation of her monuments and museums. But the cholinologists bravely dismis sed the temptations and went on with the presentations and discus sions of the many papers which form the present book. The papers describe the most recent development of investiga tions on acetylcholine. They open with an extensive coverage of the developmental and phylogenetic aspects of the cholinergic neurons. The regulation of acetylcholine synthesis, release, post synaptic, electrical and trophic effects in the peripheral chol inergic synapses including ganglia, neuromuscular junction, myen theric plexus and heart is then covered. Special emphasis is given to the cholinergic mechanisms in the eye.
Author : J. Klein
Publisher : Elsevier
Page : 397 pages
File Size : 48,18 MB
Release : 1996-12-18
Category : Medical
ISBN : 044482166X
This volume offers a comprehensive update and overview of the field of cholinergic transmission as presented by some thirty distinguished investigators who were recruited for their task from Germany, Great Britain, Canada, USA, Sweden, Israel, France and Italy. Exciting new discoveries, described in this volume, are due to recent methodological breakthroughs. These discoveries throw new light on many areas of cholinergic mechanisms.
Author : D. Jenden
Publisher : Springer
Page : 886 pages
File Size : 30,95 MB
Release : 1978-01-01
Category : Psychology
ISBN : 9780306379246
This volume represents a collection of papers which were contributed by participants at a Symposium for Cholinergic Mechanisms and Psycho pharmacology, held in La Jolla, California on March 28-30, 1977. The were chosen to emphasize areas in which there has been substantial topics progress in the past 2-3 years and fall into seven major groups dealingwith: cholinergiC receptors; chemistry, histochemistry and enzymology; cyclic nucleotides and cholinergiC mechanisms; storage, compartmentation and release of acetylcholine; regulatory mechanisms in acetylcholine metab olism; modulation of acetylcholine metabolism; and behavioral and clin ical manifestations of cholinergiC function and dysfunction. Each group contains one or more reviews and a number of shorter contributions de scribing current work. This symposium was the third in a series of which the first two were held in Skokloster, Sweden in 1970 and Boldern, Switzerland in 1974. The Proceedings of the meetings indicate a rapid development of knowledge of cholinergiC mechanisms which for many years lagged behind that of other neurotransmitters and neuroregulators. The inclusion of a large section in the present volume dealing with clinical manifestations of cholinergiC dysfunction reflects one of the most important trends in current research on cholinergiC mechanisms, namely the close inter-relationship and mutual support of basic science and clinical investigation. I hope that this volume will be of value to all those whose work relates to cholinergiC function, at both basic and clinicalleve18, and will continue to stimulate the vigorous exchange of ideas which was such a prominent feature of the Symposium.
Author : Israel Silman
Publisher : CRC Press
Page : 852 pages
File Size : 31,33 MB
Release : 2013-04-08
Category : Science
ISBN : 9781135417451
Providing a cutting-edge profile of research progress in this important field of study, Cholinergic Mechanisms: Function and Dysfunction contains a compilation of the proceedings of the Eleventh ISCM, held in St. Moritz, May 2002. Bringing together 250 contributors from 30 countries, the book presents a comprehensive picture of the cholinergic field. It provides a survey of current understanding of molecular, pharmacological, toxicological, behavioral, and clinical aspects of the cholinergic system. This volume offers a state-of-the-art account of progress in the field from the molecule in the test tube through the cell and the synapse, to the organism and the patient.
Author : Sten-Magnus Aquilonius
Publisher : Elsevier Publishing Company
Page : 493 pages
File Size : 32,52 MB
Release : 1990
Category : Acetylcholine
ISBN : 9780444811486
This international forum, sponsored by the Nobel Foundation, focussed exclusively on cholinergic mechanisms and was inspired by the first meeting of its kind, organized by Professor Edith Heilbronn and her associates some 20 years ago. The Symposium Cholinergic Neurotransmission: Functional and Clinical Aspects' took place on the Lidingo Island, Stockholm, in August 1989 and the resulting volume encompasses the contributions of a number of invited scientists prominent in the field of cholinergic neuroscience. The main objective was to provide a detailed overview of the cholinergic research-front of today with emphasis on the basic principles indicating the way to clinical applications. The chapters are organized in such a way as to guide the reader from molecular biology through basic cholinergic pharmacology into clinically oriented contributions that bear upon the number of diseases in which altered cholinergic function is pathophysiologically important, e.g. myasthenia gravis and myasthenic syndromes, disorders of movement and dementia as well as cholinergic mechanisms involved in the regulation of pain, mood and sleep."
Author : Bruce Alberts
Publisher :
Page : 0 pages
File Size : 46,15 MB
Release : 2002
Category : Cytology
ISBN : 9780815332183
Author : Mohammed Shoaib
Publisher : Springer Nature
Page : 245 pages
File Size : 44,6 MB
Release : 2020-08-29
Category : Medical
ISBN : 3030560139
The molecular genetics of the cholinergic system including both muscarinic and nicotinic acetylcholine receptors, cholinesterases, acetylcholine synthesis and release have provided significant insights into potential targeting for pharmacological intervention. Cholinergic drugs are being used or evaluated for the treatment of diseases. Thus, this volume aims to broaden our understanding of the current state of cholinergic mechanisms to enable implementation of novel approaches for the development of more effective treatments.
Author : Alexander G. Karczmar
Publisher : Springer Science & Business Media
Page : 698 pages
File Size : 34,23 MB
Release : 2007-04-05
Category : Science
ISBN : 038746526X
Even if the “weapons of mass destruction” (WMD) and, among them, stocks of organoph- phorus (OP) agents (also referred to as war gases and nerve gases) were not found in Iraq following the US-Iraq war, the relative ease with which these substances can be made from harmless precursors and the low cost of their manufacture will continue to fascinate pow- hungry, ruthless dictators, as well as multinational and international terrorists, particularly as the close relationship between the OP agents and useful insecticides makes it easy to disguise the importation and purchase of small amounts of the precursors. Indeed, the use by Saddam Hussein of a nerve gas against the Kurds and his possible employment of the OP agents during his war with Iran, and the Sarin attack in the Tokyo underground by an extremist religious set magnetized the world with respect to the OP drugs. As these drugs exert their toxicity via their cholinergic action on the nervous, particularly central nervous, system, it is no wonder that the research in the cholinergic ? eld attracts, and merits, our intense attention. These considerations underlie the signi? cance of this book, as Alex Karczmar devotes an entire chapter of Exploring the Vertebrate Central Cholinergic Nervous System to anticholinest- ases (antiChEs), and as he is an acknowledged expert in the ? eld of cholinergic toxicity as well as a consultant to the Surgeon General of the U. S. Army.
Author : M.D. Binder
Publisher : Elsevier
Page : 499 pages
File Size : 41,60 MB
Release : 1999-12-17
Category : Medical
ISBN : 0080862489
In the last decade, we have witnessed a striking maturation of our understanding of how neurons in the spinal cord control muscular activity and movement. Paradoxically, a host of new findings have revealed an unexpected versatility in the behavior of these well-studied neural elements and circuits. In this volume, the world's leading experts review the current state of our knowledge of motor control, outline their latest results and developments, and delineate the seminal unresolved questions in this vibrant field of research. The volume begins with a commentary and overview of our current understanding of the peripheral and spinal basis of motor control. The remainder of the volume is divided into seven sections, each focused on a different problem. The first chapter in each section provides some historical review and presages the experimental findings and hypotheses that are discussed in subsequent chapters.Topics include the biomechanics of neuromuscular systems, the properties of motoneurons and the muscle units they control, spinal interneurons, pattern generating circuits, locomotion, descending control of spinal circuits, comparative physiology of motor systems, and motor systems neurophysiology studied in man. The book serves as a unique reference volume and should be essential reading for anyone interested in motor systems. Moreover, the volume's comprehensive coverage of a wide range of topics make it an effective textbook for graduate level courses in motor control neurobiology, kinesiology, physical therapy, and rehabilitation medicine.