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Author : Thomas H. Shepard
Publisher : JHU Press
Page : 564 pages
File Size : 15,44 MB
Release : 2004
Category : Teratogenic agents
ISBN : 9780801879531
Links information on experimental teratogenic agents with the congenital defects in human beings.
Author : Thomas H. Shepard
Publisher :
Page : 542 pages
File Size : 21,37 MB
Release : 1995
Category : Teratogenic agents
ISBN :
Author : TH. Shepard
Publisher :
Page : pages
File Size : 39,38 MB
Release : 1989
Category :
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Author : TH. Shepard
Publisher :
Page : pages
File Size : 21,18 MB
Release : 1973
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Author : Thomas H. Shepard
Publisher :
Page : 237 pages
File Size : 45,21 MB
Release :
Category :
ISBN : 9780598251787
"The first edition of the catalog was a noble achievement and the subsequent editions have each embodied major improvements." -- Teratology
Author : Jan Marshall Friedman
Publisher :
Page : 816 pages
File Size : 29,27 MB
Release : 2000
Category : Medical
ISBN :
"This new edition will continue to serve as a reference for use by clinical and research geneticists, teratologists, obstetricians, and pediatricians."--BOOK JACKET.
Author : T.V.N. Persaud
Publisher : Springer Science & Business Media
Page : 240 pages
File Size : 48,58 MB
Release : 2012-12-06
Category : Science
ISBN : 9401159106
The study of birth defects has assumed an importance even greater now than in the past because mortality rates attributed to congenital anomalies have declined far less than those for other causes of death, such as infectious and nutritional diseases. It is estimated that as many as 50% of all pregnancies terminate as miscarriages. In the majority of cases this is the result of faulty development. Major congenital malformations are found in at least 2% of all liveborn infants, and 22% of all stillbirths and infant deaths are associated with severe congenital anomalies. Teratological studies of an experimental nature are neither ethical nor justifiable in humans. Numerous investigations have been carried out in laboratory animals and other experimental models in order to improve our understanding of abnormal intra-uterine development. In less than two decades the field of experimental teratology has advanced phenomenally. As a result of the wide range of information that is now accumulating, it has become possible to obtain an insight into the causes, mechanisms and prevention of birth defects. However, considerable work will be needed before these problems can be resolved. This book brings together some of the more recent and important research findings related to the mechanisms and pathogenesis of abnormal develop ment. It is not only a documentation of the latest experimental work, but it also points out future directions that seem productive and challenging.
Author : T H. Shepard
Publisher :
Page : pages
File Size : 31,98 MB
Release : 1980
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ISBN :
Author : Christof Schaefer
Publisher : Academic Press
Page : 920 pages
File Size : 18,99 MB
Release : 2014-09-17
Category : Medical
ISBN : 0124079016
Drugs During Pregnancy and Lactation, Third Edition is a quick and reliable reference for all those working in disciplines related to fertility, pregnancy, lactation, child health and human genetics who prescribe or deliver medicinal products, and to those who evaluate health and safety risks. Each chapter contains twofold information regarding drugs that are appropriate for prescription during pregnancy and an assessment of the risk of a drug when exposure during pregnancy has already occurred. Thoroughly updated with current regulations, references to the latest pharmacological data, and new medicinal products, this edition is a comprehensive resource covering latest knowledge and findings related to drugs during lactation and pregnancy. Provides evidence-based recommendations to help clinicians make appropriate recommendations Uniquely organized and structured according to drug class and treatment indications to offer authoritative clinical content on potential adverse effects Highlights new research developments from primary source about working mechanism of substances that cause developmental disorders
Author : Luís Félix
Publisher : Humana
Page : 614 pages
File Size : 30,94 MB
Release : 2019-06-27
Category : Medical
ISBN : 9781493993147
This detailed book provides a compilation of laboratory techniques and tests to assess the risks to embryo-fetal development from drug exposure during early developmental stages. After an introduction to teratogenicity testing, the contents explore both in vitro and in vivo techniques in the study of the teratogenic and fetotoxic effects of drugs, as well as numerous animal-based teratology methods. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and comprehensive, Teratogenicity Testing: Methods and Protocols describes methods that integrate a battery of tests that can be performed in cells, organs, tissues, and animal models for evaluating toxicity and/or the safety of compounds in early developmental stages with the goal of estimating, preventing, or minimizing the teratogenic potential of drugs.