[PDF] Carma eBook

Author : Thomas Kingsley Troupe
Publisher : Capstone
Page : 129 pages
File Size : 46,8 MB
Release : 2017-08-01
Category : Juvenile Fiction
ISBN : 1496548736

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Kurby, Risk, and Carma team up to save their mother ship, BeegMumma, from hostile aliens, but must also face prejudices while completing their mission.

Author : Frédéric Bornancin
Publisher : Frontiers Media SA
Page : 179 pages
File Size : 50,7 MB
Release : 2019-10-18
Category :
ISBN : 2889630560

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Some twenty years ago, the search began for B-cell lymphoma (BCL)-10 binding partners that connect via homophilic interaction with its N-terminal caspase recruitment domain (CARD) to induce nuclear factor-kappa B (NF-κB) activation. This effort led first to the identification of the protein CARD9. Soon afterwards, similar searches identified CARD10 (aka CARMA3), CARD11 (aka CARMA1) and CARD14 (aka CARMA2), as further BCL10 interactors. These discoveries paved the way for landmark progress in our understanding of NF-κB activation pathways downstream of several cell surface receptors on multiple cell types, focused particularly on antigen receptors on lymphocytes. An additional binding partner, called Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), was also implicated in the CARD-BCL10 pathway. Since then, the resulting “CBM” complex has been recognized as a key node in signaling cascades leading to NF-κB activation, particularly in immune cells. Mouse models of genetic deficiencies for each CBM component provided the first evidence for their critical role in cell signaling. More recently, studies of human lymphoid malignancies and novel genetic disorders have revealed important new insights. Both gain- and loss-of-function mutations were identified, establishing these CARMA/CARD proteins as key regulators of proliferation and differentiation of immune and non-immune cells, and linking them to human disease. According to the genetic defect involved, dysregulation of CARMA/CARD pathways can lead to a broad spectrum of immune disorders, including severe immune deficiencies, lymphoproliferative disorders, psoriasis and atopy. The aim of this Research Topic is to summarize and update our current understanding of CARMA/CARD protein biology, from initial discoveries to the most recent insights. It focuses on CARD9 and the CARMA proteins CARD10, CARD11 and CARD14, from genetic, signaling and disease perspectives. BCL10 and MALT1 are also reviewed in this context as critical nodes for CBM signal relay and regulation. This Research Topic also aims to delineate the next key questions in the field to guide future research efforts.

Author : Aurjoon Ghosh
Publisher : iUniverse
Page : 168 pages
File Size : 28,89 MB
Release : 2007-11
Category : Fiction
ISBN : 0595471390

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Burma is being bombed, and Ramesh's life is in disarray. Things become even more tumultuous when he beats up a British soldier who insults his sister. Ramesh is forced to flee his home in Haldipur, and he arrives in Calcutta, India. But when Hindus and Muslims start to riot in 1946, he is forced to move again, and he unwittingly leaves behind a young woman pregnant with his child. The child is born without his father's knowledge. Ramesh journeys to New York City to be with his uncle. He is drafted and sent to Korea, returns to the States, and falls in love with a woman with roots in Jamaica. But his life with his wife brings with it great family intrigue. In the meantime, Suresh, the son, has grown up and faces problems of his own. Now living in America, he's drafted and sent to Vietnam, where he vows not to kill. But it may not be a vow he can keep, especially when his very survival is at stake. Carma is a powerful story about a father and son, lost loves, war, and what it takes to transcend interracial barriers.

Author : New York (State). Court of Appeals.
Publisher :
Page : 1124 pages
File Size : 18,46 MB
Release : 1935
Category : Law
ISBN :

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Volume contains: Unreported Case or index page missing or in index after index 6 (Khoury v. County of Saratoga) Unreported Case or index page missing or in index after index 6 (Carma v. City of Saratoga) Unreported Case or index page missing or in index after index 6 (Carma v. City of Saratoga) Unreported Case or index page missing or in index after index 6 (McGettigan v. N.Y. Central R.R. Co.) Unreported Case or index page missing or in index after index 6 (McGettigan v. N.Y. Central R.R. Co.) Unreported Case or index page missing or in index after index 6 (Whalen v. N.Y. Central R.R. Co.) Unreported Case or index page missing or in index after index 6 (Canfield v. N.Y. Central R.R. Co.)

Author :
Publisher :
Page : 64 pages
File Size : 27,80 MB
Release : 1943
Category :
ISBN :

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Ancestry of Carma Erika Jacobsen (b.1941), daughter of Thomas Harold Andrew Jacobsen (b.1918) and Erika Elfriede Seiter (b.1913), Mormons living in Salt Lake City. The father's line was in Denmark; the mother's line was in Germany.

Author : California (State).
Publisher :
Page : 36 pages
File Size : 41,55 MB
Release :
Category : Law
ISBN :

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Court of Appeal Case(s): H005294