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Car Ma is Alison Mosshart's first collection in print of her art, photography, and writing. Mosshart is the lead singer for bands such as The Kills and Dead Weather. Her mother was a high school art teacher and her father a used car dealer--both influenced Car Ma's images, poems, and stories. Mosshart describes the book: "It's a book about America, performance, and life on the road. It's a book about fender bender portraiture, story tellin' tire tracks, and the never-ending search for the spirit under the hood."
Help! BeegMumma is under attack by hostile aliens. As fear and panic spread through the ship's residents, Carma and the rest of the Star Belchers leap into action. But all is not what it seems, and when prejudice threatens to ruin their mission, the Star Belchers must work even harder to make things right.
Some twenty years ago, the search began for B-cell lymphoma (BCL)-10 binding partners that connect via homophilic interaction with its N-terminal caspase recruitment domain (CARD) to induce nuclear factor-kappa B (NF-κB) activation. This effort led first to the identification of the protein CARD9. Soon afterwards, similar searches identified CARD10 (aka CARMA3), CARD11 (aka CARMA1) and CARD14 (aka CARMA2), as further BCL10 interactors. These discoveries paved the way for landmark progress in our understanding of NF-κB activation pathways downstream of several cell surface receptors on multiple cell types, focused particularly on antigen receptors on lymphocytes. An additional binding partner, called Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), was also implicated in the CARD-BCL10 pathway. Since then, the resulting “CBM” complex has been recognized as a key node in signaling cascades leading to NF-κB activation, particularly in immune cells. Mouse models of genetic deficiencies for each CBM component provided the first evidence for their critical role in cell signaling. More recently, studies of human lymphoid malignancies and novel genetic disorders have revealed important new insights. Both gain- and loss-of-function mutations were identified, establishing these CARMA/CARD proteins as key regulators of proliferation and differentiation of immune and non-immune cells, and linking them to human disease. According to the genetic defect involved, dysregulation of CARMA/CARD pathways can lead to a broad spectrum of immune disorders, including severe immune deficiencies, lymphoproliferative disorders, psoriasis and atopy. The aim of this Research Topic is to summarize and update our current understanding of CARMA/CARD protein biology, from initial discoveries to the most recent insights. It focuses on CARD9 and the CARMA proteins CARD10, CARD11 and CARD14, from genetic, signaling and disease perspectives. BCL10 and MALT1 are also reviewed in this context as critical nodes for CBM signal relay and regulation. This Research Topic also aims to delineate the next key questions in the field to guide future research efforts.
Burma is being bombed, and Ramesh's life is in disarray. Things become even more tumultuous when he beats up a British soldier who insults his sister. Ramesh is forced to flee his home in Haldipur, and he arrives in Calcutta, India. But when Hindus and Muslims start to riot in 1946, he is forced to move again, and he unwittingly leaves behind a young woman pregnant with his child. The child is born without his father's knowledge. Ramesh journeys to New York City to be with his uncle. He is drafted and sent to Korea, returns to the States, and falls in love with a woman with roots in Jamaica. But his life with his wife brings with it great family intrigue. In the meantime, Suresh, the son, has grown up and faces problems of his own. Now living in America, he's drafted and sent to Vietnam, where he vows not to kill. But it may not be a vow he can keep, especially when his very survival is at stake. Carma is a powerful story about a father and son, lost loves, war, and what it takes to transcend interracial barriers.
This groundbreaking anthology is the first to focus exclusively on the history of industrial design. With essays written by some of the greatest designers, visionaries, policy makers, theorists, critics and historians of the past two centuries, this book traces the history of industrial design, industrialization, and mass production in the United States and throughout the world.