[PDF] Cancer Biology And The Nuclear Envelope eBook

Author : Eric C. Schirmer
Publisher : Springer Science & Business Media
Page : 610 pages
File Size : 36,20 MB
Release : 2014-02-22
Category : Medical
ISBN : 1489980326

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"Nuclear envelope (NE) defects have been linked to cancer biology since the mid-1800s, but it was not until the last few years that we have begun to understand these historical links and to realize that there are myriad ways that the NE impacts on tumorigenesis. The NE is a complex double membrane system that encloses the genome while providing structural support through the intermediate filament lamin polymer and regulating protein/ mRNA trafficking and signaling between the nucleus and cytoplasm via the nuclear pore complexes (NPCs). These functions already provide some mechanisms for NE influences on cancer biology but work in the past few years has elucidated many others. Lamins and many recently identified NE transmembrane proteins (NETs) have been now shown to function in DNA repair, regulation of cell cycle and signaling, apoptosis, cell migration in metastasis and nuclear architecture and morphology. This volume presents a comprehensive overview of the wide range of functions recently identified for NE proteins and their relevance in cancer biology, providing molecular mechanisms and evidence of their value as prognostic and diagnostic markers and suggesting new avenues for the treatment of cancer. Indeed some of these recent links are already yielding promising therapies, such as the current clinical trial of selective inhibitors of the nuclear export factor exportin in certain types of leukemia, melanoma and kidney cancer."

Author : David Evans
Publisher : Garland Science
Page : 320 pages
File Size : 47,37 MB
Release : 2004-09-01
Category : Science
ISBN : 0203643399

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The Nuclear Envelope brings together the major current topics in nuclear envelope structure, transport, transcriptional regulation and cell signaling. The volume is divided into four sections: 1. Proteins of the nuclear envelope, including nuclear envelope proteomics, structure and function. 2. Nuclear pores and transport at the nuclear envelope, including pore complex structure, assembly and function and import and export pathways. 3. Nuclear envelope dynamics, including dynamics of lamina assembly and disassembly. 4. Nuclear signaling and transcription regulation, including signaling to the nucleus and spectrin repeat proteins and their implications or communication between the nucleus and cytoplasm.

Author :
Publisher : ScholarlyEditions
Page : 50 pages
File Size : 30,47 MB
Release : 2012-12-26
Category : Science
ISBN : 1481613391

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Advances in Nuclear Envelope Research and Application / 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Nuclear Envelope in a concise format. The editors have built Advances in Nuclear Envelope Research and Application / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Nuclear Envelope in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Nuclear Envelope Research and Application / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Harris Busch
Publisher :
Page : 664 pages
File Size : 17,44 MB
Release : 1974
Category : Medical
ISBN :

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The Molecular Biology of Cancer discusses the state of progress in the molecular biology of cancer. The book describes the effects of anticancer agents on nucleolar ultrastructure; the role of chromosomes in the causation and progression of cancer and leukemia; the replication, modification, and repair of DNA. The text also describes the metabolism and utilization of messenger RNA and other high molecular weight RNA and low molecular weight nuclear RNA; the characteristics, structures, and functions of nuclear proteins; and the process of protein synthesis. Nucleotides are reviewed with regard ...

Author : Roger John Benjamin King
Publisher : Pearson Education
Page : 316 pages
File Size : 14,47 MB
Release : 2006
Category : Cancer
ISBN : 9780131294547

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Providing an introduction of the biological principles of the causes and treatment of cancer, this book covers key topics in cancer biology. It is useful for students of cell biology, biochemistry, molecular biology, genetics and biomedical sciences, and postgraduate students moving into cancer research.

Author : Sundas Fayyaz
Publisher : Springer
Page : 310 pages
File Size : 30,71 MB
Release : 2018-03-07
Category : Medical
ISBN : 3319715534

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Cancer is a multifaceted disease and overwhelmingly increasing experimental evidence has helped us to develop a deeper understanding of the role of signal transduction cascades in cancer development and progression. Tissue microarrays and next generation sequencing technologies have assisted us to gather missing pieces of jigsaw puzzle and we now know that deregulation of spatio-temporally controlled signaling cascades play fundamental role in metastasis and resistance against wide ranging therapeutics. This book offers a balanced overview of the rapidly emerging cutting edge research in molecular oncology and good source of knowledge for established oncologists, basic and medical students and pharmaceutical industry associated R&D departments.

Author : Weidong Yang
Publisher : Springer
Page : 277 pages
File Size : 31,92 MB
Release : 2018-07-27
Category : Science
ISBN : 3319773097

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Dysfunction of nuclear-cytoplasmic transport systems has been associated with many human diseases. Thus, understanding of how functional this transport system maintains, or through dysfunction fails to maintain remains the core question in cell biology. In eukaryotic cells, the nuclear envelope (NE) separates the genetic transcription in the nucleus from the translational machinery in the cytoplasm. Thousands of nuclear pore complexes (NPCs) embedded on the NE selectively mediate the bidirectional trafficking of macromolecules such as RNAs and proteins between these two cellular compartments. In this book, the authors integrate recent progress on the structure of NPC and the mechanism of nuclear-cytoplasmic transport system in vitro and in vivo.