[PDF] Bone Metastases From Prostate Cancer eBook

Author : Francesco Bertoldo
Publisher : Springer
Page : 293 pages
File Size : 13,82 MB
Release : 2016-11-07
Category : Medical
ISBN : 3319423274

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This book presents up-to-date information on one of the hottest topics in prostate cancer, namely bone metastases. The most recent developments with respect to biology, pathology, diagnosis, and treatment are described, providing readers with an excellent understanding of the mechanisms of metastasis formation, the characteristics of metastases, their aggressiveness, and prognostic factors for treatment response. The coverage includes discussion of all of the best available options (laboratory, radiology, and nuclear medicine) for achieving early diagnosis and both established and novel therapeutic approaches. Detailed information is provided on hormonal manipulations, bone-targeted agents, vaccines, taxanes, and other treatments that are enriching the therapeutic armamentarium. The editors can be considered leaders in the field, with great experience in diagnostic and clinical oncology and research, and the authors are experts in diverse specialties. This ensures a multidisciplinary approach, mirroring the current situation in which treatment in patients with bone metastases is undertaken by a team of specialists and health professionals in a variety of fields.

Author : James P. Karr
Publisher : Springer Science & Business Media
Page : 316 pages
File Size : 32,40 MB
Release : 2012-12-06
Category : Medical
ISBN : 1461533988

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The biology of solid tumor metastasis has been the subject of significant scientific and clinical interest for years and while experimental evidence reveals that metastasis is not solely a random event, very little is known about the biology of metastasis originating from prostate cancer. This is in spite of the fact that the majority of prostate cancer patients die with metastatic lesions to the bone. Progress in understanding this most important aspect of prostate cancer has been hampered by the lack of suitable animal models and an inability to accurately quantify bone metastases and their responses to therapy. Over the past decade, scientists in Japan and the United States have steadily advanced our understanding of the cellular, molecular and immunologic biology of primary and disseminated prostate cancer. It is this body of new information, combined with advances in imaging techniques and prostate cancer tumor markers, that prompted the need for an in-depth assessment of bone metastasis of prostate cancer. Accordingly, on December 12, 1990, a group of basic and clinical investigators from Japan and the United States convened in Gotenba, Japan, to hold the first conference devoted solely to the basic biology and clinical aspects of bone metastases originating from prostate cancer. The cross-fertilization of ideas that was fostered through in-depth discussion of technological advances among various basic and clinical disciplines not only further advanced our understanding of prostate metastases to the bone, but suggested approaches for precise quantitative assessment of these lesions and their treatment.

Author : Thomas N. Byrne
Publisher : Oxford University Press
Page : 429 pages
File Size : 43,56 MB
Release : 2000-01-13
Category : Language Arts & Disciplines
ISBN : 0195129687

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Diseases of the Spine and Spinal Cord reviews the full spectrum of disorders affecting this region including primary spinal tumors and metastases, infection, degenerative diseases, and trauma. Presenting an inter-disciplinary perspective, the book includes up-to-date information on therapy [including neurosurgical], new information on developmental disorders of the spine, and a definitive chapter on trauma, including information on biomechanics. A separate chapter on pain syndromes also is included.

Author : Robert C. Bast, Jr.
Publisher : John Wiley & Sons
Page : 2004 pages
File Size : 32,89 MB
Release : 2017-03-10
Category : Medical
ISBN : 111900084X

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Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Author : R. Lor Randall
Publisher : Springer
Page : 356 pages
File Size : 11,76 MB
Release : 2015-12-01
Category : Medical
ISBN : 1461456622

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Providing an integrated approach to the diagnosis and management of patients with metastatic bone disease (MBD), this comprehensive text combines discussion of the pathobiology of the disease with the latest oncological and orthopedic treatment modalities. After opening with an examination of the epidemiology and impact of MBD, the biology of bone metastases are discussed, along with considerations of the tissue of origin. Evaluation, biopsy and medical therapy, including metabolic agents and bio targeting. The heart of the book presents oncological approaches (supportive, radiation and interventional) and principles of orthopedic surgical oncology, with subsequent chapters covering specific anatomy, from the pelvis to the lower extremity and the spine. Chapters on emerging surgical technology and future directions conclude the text and redefine an integrated approach to patient care. Taken together, Metastatic Bone Disease is an excellent resource for orthopedic surgeons and cancer specialists alike.

Author : Vassilios Vassiliou
Publisher : Springer Science & Business Media
Page : 479 pages
File Size : 31,57 MB
Release : 2013-11-19
Category : Medical
ISBN : 9400775695

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The second edition of this book serves both as an introductory and reference book focusing on the field of metastatic bone disease. Featuring contributions from experts in the field, this volume describes the molecular and cellular mechanisms involved in the formation of bone metastases, presents the newer advances made in the understanding of the clinical picture and symptoms of patients, analyses the role of bone markers in research and clinical practice and deals with all aspects of imaging modalities applied for the detection and evaluation of bone metastases. Moreover, the use of all available treatment methods, such as radiotherapy, surgery and systemic treatments for the management of patients with metastatic bone disease is discussed in detail. Overall this volume presents a thorough overview of all aspects of metastatic bone disease and provides a comprehensive and concise information resource for researchers, oncologists, orthopaedic surgeons and clinicians dealing with patients with metastatic bone disease.

Author : A. Mark Davies
Publisher : Springer Science & Business Media
Page : 694 pages
File Size : 12,66 MB
Release : 2009-08-21
Category : Medical
ISBN : 3540779841

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Detection and characterization of bone tumors with imaging remains a big challenge for every radiologist notwithstanding the impressive progress achieved by the introduction of several new imaging modalities. Moreover, new concepts in surgical and oncological treatment of these lesions require from the radiologist appropriate and focused answers to the specifc questions asked by the referring physicians in order to choose the best therapeutic approach for the in- vidual patient. Tis comprehensive textbook describes in detail the possibilities and limits of all moda- ties, including MRI, CT, nuclear medicine and interventional radiological procedures, employed for the modern imaging of tumoral and tumor-like lesions of bone. Teir role in the diagnosis, surgical staging, biopsy and assessment of response to therapy is discussed in detail, covering all tumor subtypes as well as their specifc anatomical location.Well selected and technically imp- cable illustrations strongly enhance the didactic value of this work. I am very much indebted and grateful to the three editors: A. Mark Davies, Murali Sundaram and Steven L. J. James, world authorities in musculoskeletal radiology, for their superb scientifc achievement in preparing and editing this wonderful volume as well as for their individual ch- ters. I would also like to thank the large international group of collaborating authors, who are also widely acknowledged for their specifc expertise in the area of bone tumors, for their outstanding contributions.

Author : Richard J. Ablin
Publisher : Springer Science & Business Media
Page : 405 pages
File Size : 20,4 MB
Release : 2007-09-05
Category : Medical
ISBN : 1402058470

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This volume brings together the key research issues in clinical and laboratory science relating to metastasis in prostate cancer. Coverage ranges from the most fundamental aspects of the molecular biology of metastasis, to the patient in the clinic. The therapeutic approaches range from conventional drug design to immunogene therapy. Prostate cancer is an area of intense research effort, and this book provides a window on contemporary research in this important area.

Author : Lance Coetzee
Publisher : Karger Medical and Scientific Publishers
Page : 34 pages
File Size : 49,38 MB
Release : 2017-02-03
Category : Medical
ISBN : 1910797405

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Information + Taking Control = Best Outcome is the theme running throughout this short, superbly illustrated workbook. Designed to help patients equip themselves with the best information about metastatic prostate cancer, it covers: • how prostate disease spreads and where it can spread to • a summary of diagnostic tests with detailed explanations to aid understanding of PSA levels, staging and Gleason score • all the hormone treatment options and their side effects • what to expect from the disease itself • how to manage key symptoms such as bone pain, urinary problems and fatigue • the treatment options when hormone treatment stops working • useful advice on diet, exercise, and getting the right support • a frank discussion of end of life care • a concise overview of the latest research in this area. With FastTests to test patients' understanding of their condition, handy checklists and plenty of space for patients and their doctors, nurses and family to write notes, this concise, easy-to-read resource will help patients get organized so that they are better equipped to ask the right questions and have more meaningful discussions about their treatment. Ultimately, it will help them make the best decisions about their care. Contents: • Information + Taking Control = Best Outcome • What is metastatic prostate cancer? • What do my test results mean? • Why is my cancer staged? • How will the disease affect me? • How is metastatic prostate cancer treated? • What is available after hormone therapy? • What are the side effects of hormone treatment? • What can I do to help myself? • Monitoring the effects of therapy • Treatment when myeloma returns • End of life care • What is the latest research in this area? • Useful resources

Author : Evan T. Keller
Publisher : Springer Science & Business Media
Page : 378 pages
File Size : 25,98 MB
Release : 2012-12-06
Category : Medical
ISBN : 1441991298

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- National Cancer Institure Budget is encouraging research in order to develop a better understanding of metastasis of cancer to the bone - Provides the reader with comprehensive reviews written by well known experts on related topics