[PDF] Biology Of Relaxin And Its Role In The Human eBook

Author : Alexander I. Agoulnik
Publisher : Springer Science & Business Media
Page : 161 pages
File Size : 25,46 MB
Release : 2008-12-19
Category : Medical
ISBN : 0387746722

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This comprehensive book contains the latest information on diverse biological functions of relaxin and related peptide found since the recent discovery of relaxin receptors. It also describes the evolution of relaxin family peptides and their receptors, molecular mechanisms of ligand/receptor interaction and the analysis of activated signaling pathways.

Author : Christian Schwabe
Publisher : Springer Science & Business Media
Page : 198 pages
File Size : 27,25 MB
Release : 2013-03-09
Category : Science
ISBN : 3662129094

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Relaxin, perhaps more than any other hormone, has a varied history of eliciting enthusiasm, rejection, skepticism, and long lapses of neglect. Long after its discovery, it was a hormone in search of a physiological role in humans. Today, relaxin is implicated in mammary growth, development and function, ionotropic and chronotropic action on the heart, and angiogenic activity in both the peripheral tissues and the endometrium. It is best known for its effect on the uterus and the symphysis pubis in preparation for parturition. However, the literature suggests that not all functions occur in one species. This book describes how to obtain the necessary molecules or derivatives for research, reaching right into the design of new molecules for specific applications.

Author : O. David Sherwood
Publisher : Wiley-Blackwell
Page : 544 pages
File Size : 36,80 MB
Release : 2005-06-10
Category : Science
ISBN : 9781573314855

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Relaxin is a protein hormone, produced and secreted during pregnancy in mammalian species, having superficial structural features resembling those of insulin. Since its initial isolation from the ovaries of pregnant pigs in 1976, increasing interest in relaxin has led to increased understanding of the chemistry, synthesis, secretion, biological roles, mechanisms of action, and potential clinical applications of relaxin in humans and domestic animals. In pigs, rats, and mice, relaxin promotes growth and softening of the cervix, enabling rapid and safe delivery of the fetuses. In these species relaxin also promotes growth and development of the mammary apparatus. Recently, biological effects of relaxin in the heart, kidney, liver, and brain have been identified, and these discoveries have triggered additional interest in possible clinical applications for relaxin. In 2002, a second form of relaxin, which is found primarily in the brain, was discovered. Relaxin-like factor (also called insulin 3), which was discovered in 1993, is produced in the fetal testis and plays a major role in testicular descent during development. The recent identification of the receptors for both relaxin and relaxin-like factor has enabled more rigorous studies of the target tissues and mechanisms of action of these hormones. This volume contains a description of recent advances and future research and clinical possibilities in the field of relaxin and related peptides. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.

Author : Ralph Anderson
Publisher : Springer Science & Business Media
Page : 357 pages
File Size : 40,55 MB
Release : 2013-03-09
Category : Medical
ISBN : 1461333687

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The Fifteenth Midwest Conference on Endocrinology and Metabolism, held at the University of Missouri-Columbia on October 11 and 12th, 1979, hosted the most prominent active researchers in the world on the subject of the hormone relaxin. Each speaker presented an in-depth coverage of his chosen topic and area of expertise. Some of the data presented in this book are findings which have not been pub lished in a scientific journal. The topic of this conference is especially timely in light of the fact that this is a first confer ence devoted specifically to the hormone relaxin. Progress on this hormone has been exceedingly rapid in recent years and many signif icant breakthroughs are documented in these pages. Lively discus sions following each presentation attest to the enthusiastic research effort being pursued at the present time concerning relaxin. Traditionally the Midwest Conferences on Endocrinology and Metabolism have emphasized breadth as well as depth of coverage. The present Conference has covered the many active areas of research in relaxin, including morphological aspects of the hormone's origin, chemical purification and chemical structure, bioassays, radioimmuno assays, receptors, mechanism of biochemical action and physiological responses to the hormone. Advances in relaxin were slow since its discovery by Dr. Frederick Hisaw, Sr. in 1926 until the availability of homogenous preparations some seven years ago. In the suceeding seven years, activity in the subject has accelerated remarkably.

Author : Sangdun Choi
Publisher : Springer
Page : 6330 pages
File Size : 22,93 MB
Release : 2017-12-15
Category : Medical
ISBN : 9781493968008

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The second edition of this encyclopedia presents over 400 biologically important signaling molecules and the content is built on the core concepts of their functions along with early findings written by some of the world’s foremost experts. The molecules are described by recognized leaders in each molecule. The interactions of these single molecules in signal transduction networks will also be explored. This encyclopedia marks a new era in overview of current cellular signaling molecules for the specialist and the interested non-specialist alike. Currently, there are more than 30,000 genes in human genome. However, not all the proteins encoded by these genes work equally in order to maintain homeostasis. Understanding the important signaling molecules as completely as possible will significantly improve our research-based teaching and scientific capabilities.

Author : Geoffrey W. Tregear
Publisher : Springer Science & Business Media
Page : 496 pages
File Size : 24,83 MB
Release : 2001
Category : Medical
ISBN : 9781402000683

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This publication contains the proceedings of "Relaxin 2000: The Third International Conference on the Hormone Relaxin & Related Peptides", held on October 22-27, 2000, at the Cable Beach Resort, Broome, Australia. Delegates from academia and industry who attended this meeting, the latest in an irregular series, participated in an exciting scientific program that covered all aspects of current relaxin research, the growth of which in recent years has been stellar. Seminal topics presented at the conference and in this book include: clinical roles for relaxin, elucidation of novel sites of action of the hormone, relaxin-induced signal transduction, identification of non-pregnant roles of the hormone, and of novel relaxin-related peptides (particularly insl 3 and 5) and their possible synergistic actions with relaxin. Audience: This book will be of considerable interest to both endocrinologists and protein researchers, including those engaged in studies in members of the insulin super-family.