[PDF] Biological Application Of Anti Idiotypes eBook

Author : Constantin A. Bona
Publisher : CRC Press
Page : 194 pages
File Size : 31,77 MB
Release : 2018-01-18
Category : Health & Fitness
ISBN : 1351078674

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The goal of this book is to present findings which are supportive of the concept that the words of the idiotype dictionary and likewise self-recognition are essential for communication between lymphocyte clones while some unfaithful ( infidel ) copies of the words contained in the idiotype dictionary perhaps play a role in the functional regulation of nonlymphoid cells.

Author : Constantin A. Bona
Publisher : CRC Press
Page : 516 pages
File Size : 41,77 MB
Release : 2018-01-18
Category : Health & Fitness
ISBN : 1351087134

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The goal of this book is to present findings which are supportive of the concept that the words of the idiotype dictionary and likewise self-recognition are essential for communication between lymphocyte clones while some unfaithful ( infidel ) copies of the words contained in the idiotype dictionary perhaps play a role in the functional regulation of nonlymphoid cells.

Author : Constantin A. Bona
Publisher :
Page : 210 pages
File Size : 18,49 MB
Release : 2018
Category : Anti-idiotypic antibodies
ISBN : 9781351070232

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"The goal of this book is to present findings which are supportive of the concept that the words of the idiotype dictionary and likewise self-recognition are essential for communication between lymphocyte clones while some unfaithful (?infidel?) copies of the words contained in the idiotype dictionary perhaps play a role in the functional regulation of nonlymphoid cells."--Provided by publisher.

Author : D. Scott Linthicum
Publisher : Springer Science & Business Media
Page : 322 pages
File Size : 11,2 MB
Release : 2012-12-06
Category : Medical
ISBN : 1461237343

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Here is an up-to-date review of important new methods and results in anti-idiotypes, receptors, and molecular mimicry. It begins with a discussion of the theoretical background of the anti-idiotypic network, it's role in the regulation of immune response, and the physical characteristics of anti-idiotypic antibodies. It then goes on to explore many exciting applications in such areas as insulin action, thyroid cell function, the neurosciences, cardiology, virology, pharmacology, and reproduction.

Author : Mark Greene
Publisher : Springer Science & Business Media
Page : 498 pages
File Size : 48,7 MB
Release : 2013-11-11
Category : Medical
ISBN : 1468447394

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The phenomenon of idiotypy was discovered almost thirty years ago, but it was only during the past decade that it attracted widespread interest and became the subject of numerous research investigations. From the outset, much of the interest in idiotypy was based on its implications with respect to the repertoire of antibodies. Kunkel showed, for example, that idiotypes associated with certain human myeloma or Bence-Jones proteins were present in normal human globulins at levels of less than one part per million. Also, Oudin's original definition of idiotypy implied that idiotypes could be uniquely associated with individual rabbits as well as with particular antigen-binding specificities. Such observations provided some of the earliest evidence for an extensive repertoire of immunoglobulin molecules. The implications of these findings have been amply confirmed by recent studies of protein struc ture and molecular genetics; many of these studies are reviewed in the present volume. It is known now that the diversity of antibodies is based on the presence of numerous V and L V H genes, on recombinatorial events involving D and] segments, on somatic mutations, and on processes involving deletion of DNA followed by repair with errors, including inser tions. Each of these parameters is capable of influencing the idiotype expressed by the final immunoglobulin product. Regulation of the immune response is another area in which idiotypy has significantly influenced modern immunology.

Author : Heinz Köhler
Publisher : Academic Press
Page : 469 pages
File Size : 48,63 MB
Release : 2013-10-22
Category : Science
ISBN : 1483269833

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Idiotypy in Biology and Medicine aims to serve the increasing interest and involvement in the practical aspects of idiotypy in biological systems. The concept of idiotypy has received wide recognition and interest far beyond the area of immunology. Experiments and interpretation of findings, reported here, clearly support the general nature of the idiotype concept in manipulating biological systems to correct pathological conditions or to improve the immune adaptation to environmental factors. The book is organized into three sections. Section 1 discusses original concepts of idiotypic manipulations. It reviews old and recent data important for the concept of an idiotype network and reports on attempts to deal with the T-cell receptor paradox; explains the immune system in terms of a circular idiotype network that can be demonstrated by sequential immunization; and emphasizes the need for restrictions in network interactions. Section 2 addresses the role and activity of idiotypic and antiidiotypic antibodies in the regulation of the immune system. Section 3 takes the issue of idiotype-antiidiotype out of the realm of the immune system and discusses it as a new principle to analyze and manipulate biological systems in general.

Author : Pierre-Andre Cazenave
Publisher : Springer
Page : 160 pages
File Size : 28,63 MB
Release : 1991
Category : Health & Fitness
ISBN :

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Vaccines have historically been considered to be the most cost-effective method for preventing communicable diseases. It was a vaccine~hat enabled global eradication of the dreaded disease smallpox. Mass immunization of children forms the anchor of the strategy of the World Health Organization (WHO) to attain "health for all" status by the year 2000. Vaccinology is undergoing a dimensional change with the advances that have taken place in immunology and genetic engineering. Vaccines that confer short or inadequate immunity or that have side effects are being replaced by better vaccines. New vaccines are being developed for a variety of maladies. Monoclonal antibodies and T cell clones have been employed to delineate the immunodeterminants on microbes, an approach elegantly complemented by computer graphics and molecular imaging techniques. Possibilities have opened for obtaining hitherto scarce antigens of parasites by the DNA recombinant route. Better appreciation of the idiotypic network has aroused research on anti-idiotypic vaccines. Solid-phase synthesis of peptides is leading to an array of synthetic vaccines, an approach that is expected to attain its full potential once the sequences activating suppressor cells are discovered and the rules for presentation of antigens to T and B cells are better worked out. A new breed of vaccines is on the horizon that seeks to control fertility.