[PDF] Beta Cell Functional Plasticity In Type 2 Diabetes Development And Remission eBook

Author : Enzo Bonora
Publisher : Springer
Page : 0 pages
File Size : 31,6 MB
Release : 2018-10-23
Category : Medical
ISBN : 9783319450148

GET BOOK

This book provides the reader with comprehensive information on the epidemiology, etiology, pathogenesis, pathophysiology, clinical features, prevention, and treatment of diabetes with the aim of empowering health care providers in their daily battle against the disease. Diabetes has been identified by WHO and the United Nations as a medical emergency because of the increase in its global prevalence, which may reach one billion in three to four decades if the trend remains unchanged. Despite improved care that is helping to prolong life, diabetes impacts substantially on the quality of life of those affected and kills or disables several million people each year. The disease is systemic because all organs, tissues, and cells suffer in the presence of hyperglycemia and are damaged by the diabetic milieu. Unfortunately, most patients with diabetes will consequently experience chronic diabetic complications. This book, combining basic science with a practical clinical orientation, will be of value for all physicians and nurses who care for patients with diabetes.

Author : Atta-ur-Rahman
Publisher : Bentham Science Publishers
Page : 249 pages
File Size : 41,9 MB
Release : 2016-06-07
Category : Science
ISBN : 1681081857

GET BOOK

Frontiers in Clinical Drug Research – Diabetes and Obesity is an eBook series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of two metabolic diseases – diabetes and obesity. The scope of the eBook series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of natural and synthetic drugs affecting endocrine and metabolic processes linked with diabetes and obesity. Reviews in this series also include research on specific receptor targets and pre-clinical / clinical findings on novel pharmaceutical agents. Frontiers in Clinical Drug Research – Diabetes and Obesity is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in the field of diabetes and obesity research. The second volume of this series features 7 reviews presenting updates on hormones and several classes of drugs: -Osteocalcin action in glucose metabolism -Sodium-glucose co-transporter 2 (SGLT2) inhibitors -Glucagon-like peptide-1 (GLP-1) mimetics -Dipeptidyl peptidase 4 (DPP-4) inhibitors -New drugs in clinical trial and commercial phases

Author : Andrew J. Krentz
Publisher : Springer
Page : 556 pages
File Size : 49,30 MB
Release : 2019-04-02
Category : Medical
ISBN : 3030117480

GET BOOK

This book aims to aid the selection of the most appropriate methods for use in early phase (1 and 2) clinical studies of new drugs for diabetes, obesity, non-alcoholic fatty liver disease (NAFLD) and related cardiometabolic disorders. Clinical research methods to assess the pharmacokinetics and pharmacodynamics of new diabetes drugs, e.g. the euglycemic clamp technique, have become well-established in proof-of-mechanism studies. However, selection of the most appropriate techniques is by no means straightforward. Moreover, the application of such methods must conform to the regulatory requirements for new drugs. This book discusses the need for new pharmacotherapies for diabetes, obesity and NAFLD and the molecular targets of drugs currently in development. Emerging technologies including functional imaging, circulating biomarkers and omics are considered together with practical and ethical issues pertaining to early phase clinical trials in subjects with cardiometabolic disorders. Translational Research Methods in Diabetes, Obesity, and Non-Alcoholic Fatty Liver Disease is of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.

Author : Joel Rodriguez-Saldana
Publisher : Springer
Page : 1040 pages
File Size : 23,56 MB
Release : 2019-06-27
Category : Medical
ISBN : 3030118150

GET BOOK

Diabetes has become a worldwide health problem, the global estimated prevalence approaches ten percent and the burden of this disease in terms of morbidity and mortality is unprecedented. The advances acquired through the knowledge of the mechanisms of the disease and the variety of therapeutic approaches contrast with the inability of private and public health systems in underdeveloped and even developed countries to achieve the goals of treatment. This paradox has been described in many sources: the surge of scientific advances contrast with an unprecedented amount of human suffering. Thus, a patient centered and an evidence based approach with the capacity to produce measurable clinical and economic outcomes is required. The purpose of this textbook is multiple: to offer a comprehensive resource covering all aspects of outpatient management; to address diabetes as a health problem from an epidemiological, economic and clinical perspective; to discuss the role of social determinants of health on the worldwide increase in diabetes; to highlight the challenges and obstacles in providing adequate care; and to outline a multidisciplinary approach to management in which medical visits retain their importance as part of a team comprising the patient, his or her family and a multidisciplinary group of health professionals who are able to move beyond the traditional approach of diabetes as a disease and greatly improve outcomes.

Author : B. Kyewski
Publisher : Springer Science & Business Media
Page : 331 pages
File Size : 21,89 MB
Release : 2006-01-09
Category : Medical
ISBN : 3540277021

GET BOOK

The vertebrate immune system defends the organism against invading pathogens while at the same time being self-tolerant to the body’s own constituents thus preserving its integrity. Multiple mechanisms work in concert to ensure self-tolerance. Apart from purging the T cell repertoire from auto-reactive T cells via negative selection in the thymus dominant tolerance exerted by regulatory T cells plays a major role in tolerance imposition and maintenance. Among the various regulatory/suppressive cells hitherto described, CD4+CD25+ regulatory T cells (Treg) and interleukin-10 producing T regulatory 1 (Tr1) cells have been studied in most detail and are the subject of most articles in this issue. Treg, also called "natural" regulatory T cells, will be traced from their intra-thymic origin to the site of their action in peripheral lymphoid organs and tissues. The repertoire of Treg is clearly biased towards recognition of self-antigens, thereby potentially preventing autoimmune diseases such as gastritis and oophoritis. Regulatory T cells, however also control infections, allergies and tolerance to transplanted tissues and this requires their induction in the periphery under conditions which are not yet fully understood. The concept of dominant tolerance, by far not novel, will offer new insights and hopefully tools for the successful treatment of autoimmune diseases, improved cancer immunotherapy and transplant survival. The fulfillment of these high expectations will, however, require their unambiguous identification and a better understanding of their mode of action.

Author : Catherine Belzung
Publisher : Springer Science & Business Media
Page : 447 pages
File Size : 30,74 MB
Release : 2014-07-08
Category : Medical
ISBN : 364236232X

GET BOOK

This volume brings together authors working on a wide range of topics to provide an up to date account of the underlying mechanisms and functions of neurogenesis and synaptogenesis in the adult brain. With an increasing understanding of the role of neurogenesis and synaptogenesis it is possible to envisage improvements or novel treatments for a number of diseases and the possibility of harnessing these phenomena to reduce the impact of ageing and to provide mechanisms to repair the brain.