[PDF] Basic Mutagenicity Tests eBook

Author : David J. Kirkland
Publisher : Cambridge University Press
Page : 164 pages
File Size : 36,96 MB
Release : 1990-08-31
Category : Medical
ISBN : 9780521393478

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A summary of the essential texts that must be performed on all new compounds before they can be registered for use in the UK.

Author : Ashutosh Kumar
Publisher : Academic Press
Page : 352 pages
File Size : 31,67 MB
Release : 2017-09-26
Category : Science
ISBN : 0128092602

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Mutagenicity: Assays and Applications presents an extensive examination of the detection, assessment and future of mutagenicity, particularly as it concerns human health and the environment. Chapters focused on specific types of mutagens or testing methods for their detection collectively explore the current state of human and environmental mutagenesis, future perspectives and regulatory needs. The test procedures for measuring mutagenicity, their advantages and limitations are described with practical and procedural detail, along with their presentation and data processing aspects. It is an essential reference covering the breadth and depth of the field of mutagenicity studies and regulation. By providing both important introductory material and practical assays and applications, this book is useful to graduate students, academic and industry researchers and regulators at various stages of their careers, leading to improved risk assessment and regulation. Presents an up-to-date and in-depth review of the current state of mutagenesis research Draws upon the combined experience and expertise of an international group of highly respected editors and chapter authors Provides an introduction to the concept of mutagenesis with particular consideration given to novel chemicals and materials

Author : B.J. Kilbey
Publisher : Elsevier
Page : 876 pages
File Size : 36,2 MB
Release : 2012-12-02
Category : Medical
ISBN : 0444600981

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The compilation of this book was prompted by the necessity of a bench volume which could provide the necessary background information on materials, experimental design, pitfalls and dificulties, in order to perform a particular test in an acceptable way with a minimal need for additional expert help. This Second Edition updates this information, providing: - a comprehensive bench guide - methods known to be reliable - a broad spectrum of approaches - tips to avoid pitfalls when using unfamiliar techniques - data from population records - safety aspects of mutagens and carcinogens - basic statistical concepts for experiment design This `on the bench' methodological text provides the necessary information for most of the common assays for genetic damage in use. The book includes methods which have been sufficiently used and tested to make their use reliable, but also presents methods which are not widely used at present, but which might prove most useful in screening for mutagenic effects.

Author : United Kingdom Environmental Mutagen Society. Sub-Committee on Guidelines for Mutagenicity Testing
Publisher : Cambridge University Press
Page : 179 pages
File Size : 40,99 MB
Release : 1993-11-11
Category : Medical
ISBN : 052145073X

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Originally published in 1993, this volume describes supplementary tests used to assess risks of in vitro mutagenicity when basic safety tests were inconclusive.

Author : David J. Kirkland
Publisher : Cambridge University Press
Page : 176 pages
File Size : 47,10 MB
Release : 1993-11-11
Category : Medical
ISBN : 9780521450737

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Originally published in 1993, this volume describes a complementary selection of tests to those described in the companion volume Basic Mutagenicity Tests (Cambridge University Press, 1990). These supplementary tests were used to assess risks of in vitro mutagenicity in those instances where the basic tests were inconclusive. As such, these tests had an important role in the assessment of the safety of compounds, drugs and chemicals. These supplementary test and guidelines, originally drawn up by the United Kingdom Environmental Mutagen Society (UKEMS) were fully revised in this publication to take full account of different regulatory guidelines and scientific advances. This volume will be of value to anyone with aninterest in regulatory affairs, mutagenicity testing and the registration of chemical products in the UK and Europe.

Author : S. Venitt
Publisher :
Page : 378 pages
File Size : 32,5 MB
Release : 1984
Category : Language Arts & Disciplines
ISBN :

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LABORATORY MANUAL. GENETIC TOXICOLOGY. BACTERIA. YEAST. FRUIT FLY. CULTURED MAMMALIAN CELLS. CYTOGENETIC TESTING. RODENTS. DOMINANT LETHAL TEST.

Author : David J. Kirkland
Publisher : Cambridge University Press
Page : 316 pages
File Size : 26,2 MB
Release : 2008-01-03
Category : Medical
ISBN : 9780521048149

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This rigorous and practical account of the interpretation of mutagenicity test data draws upon the expertise of toxicologists and statisticians. Chemicals, such as drugs, food additives and pesticides, all need careful screening to eliminate potentially mutagenic compounds.

Author : OECD
Publisher : OECD Publishing
Page : 12 pages
File Size : 20,36 MB
Release : 1997-07-21
Category :
ISBN : 9264071245

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The bacterial reverse mutation test uses amino-acid requiring at least five strains of Salmonella typhimurium and Escherichia coli to detect point mutations by base substitutions or frameshifts. The principle of this bacterial reverse mutation test ...

Author : OECD
Publisher : OECD Publishing
Page : 16 pages
File Size : 34,82 MB
Release : 2011-07-28
Category :
ISBN : 9264122818

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This Test Guideline describes an in vivo assay that detects chemicals that may induce gene mutations. In this assay, transgenic rats or mice that contain multiple copies of chromosomally integrated plasmid or phage shuttle vectors are used. The ...