[PDF] Arrhythmic And Vascular Complications Of Coronavirus Disease 2019 Covid 19 An Issue Of Cardiac Electrophysiology Clinics Volume 14 1 eBook
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In this issue of Cardiac Electrophysiology Clinics, guest editors Drs. Domenico G. Della Rocca, Giovanni B. Forleo, and Andrea Natale bring their considerable expertise to the topic of Arrhythmic and Vascular Complications of Coronavirus Disease 2019 (COVID-19). Top experts in the field cover key topics such as prevalence and clinical implications of COVID-19 myocarditis; electrocardiographic and echocardiographic features of COVID-19 patients; imaging findings of COVID-19-related cardiovascular complications; the role of digital health during COVID-19 pandemic; and more. Contains 14 relevant, practice-oriented topics including prevalence, management, and outcomes of supraventricular arrhythmias in COVID-19 patients; prevalence, management, and outcomes of ventricular arrhythmias in COVID-19 patients; COVID-19 associated endothelial dysfunction and microvascular injury; COVID-19, acute myocardial injury, and infarction; and more. Provides in-depth clinical reviews on arrhythmic and vascular complications of COVID-19, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
In this issue of Cardiac Electrophysiology Clinics, guest editors Drs. Domenico G. Della Rocca, Giovanni B. Forleo, and Andrea Natale bring their considerable expertise to the topic of Arrhythmic and Vascular Complications of Coronavirus Disease 2019 (COVID-19). Top experts in the field cover key topics such as prevalence and clinical implications of COVID-19 myocarditis; electrocardiographic and echocardiographic features of COVID-19 patients; imaging findings of COVID-19-related cardiovascular complications; the role of digital health during COVID-19 pandemic; and more. Contains 14 relevant, practice-oriented topics including prevalence, management, and outcomes of supraventricular arrhythmias in COVID-19 patients; prevalence, management, and outcomes of ventricular arrhythmias in COVID-19 patients; COVID-19 associated endothelial dysfunction and microvascular injury; COVID-19, acute myocardial injury, and infarction; and more. Provides in-depth clinical reviews on arrhythmic and vascular complications of COVID-19, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
COVID-19 Consequences on Cardiovascular System: Immediate, Intermediate, and Long-Term Complications covers all the aspects related with the interplay between SARS-COV-2 infection and the cardiovascular system, from bench to bedside and from acute infection to long-term complications. Written by a team of experts, this book is a one-stop-shop reference for both healthcare professionals and researchers who require a comprehensive view into the deleterious effects of COVID-19 on the cardiovascular system, the relationship of cardiovascular risk factors with COVID-19 prognosis, and further insights on the biomarkers that currently make it possible to predict and monitor the evolution of the disease at the cardiovascular level. Scientific evidence demonstrates that while COVID-19 primarily affects the lungs, it also affects multiple organs, particularly the cardiovascular system, with its most common complications being arrhythmia, cardiac injury, fulminant myocarditis, heart failure and pulmonary embolism. Covers all the current scientific pieces of evidence about the effects of COVID-19 on the heart and cardiovascular system from both a basic and a clinical point of view. Discusses immediate, intermediate, and long-term complications of COVID-19 on the cardiovascular system. Includes studies conducted worldwide by well-known experts in related fields.
In this issue of Cardiology Clinics, guest editors Drs. Timothy D. Henry and Santiago Garcia bring their considerable expertise to the topic of COVID-19. Top experts in the field cover key topics such as prothrombotic effects of COVID-19; impact of the COVID-19 pandemic on acute myocardial infarction care; impact of the COVID-19 pandemic on cardiac arrest and emergency care; vaccine-related cardiovascular effects; and more. Contains 11 relevant, practice-oriented topics including cardiovascular manifestations of COVID-19; use and prognostic implications of cardiac biomarkers (Troponin); COVID-19: Insights from cardiac pathology; ACS in COVID-19; STEMI in COVID-19; and more. Provides in-depth clinical reviews on COVID-19, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Cardiac arrhythmias, particularly ventricular arrhythmias, can be life-threatening and caused by both congenital genetic mutations and acquired cardiac injury. My thesis work was originally focused on delineating the effects of genetic mutation-driven dysregulation of a protein called Hey2 in Brugada Syndrome, a complex disease characterized by a predisposition to dangerous arrhythmias originating in the right ventricular outflow tract. In response to the pandemic, my thesis work shifted toward understanding the mechanisms of cardiovascular injury in Coronavirus disease 2019 (COVID-19), which is associated with serious cardiovascular complications, including ventricular arrhythmias and sudden cardiac death as well as endothelial dysfunction and coagulopathies. While the main dissertation is focused on the COVID-19 work, the original Hey2 project is covered in a supplemental chapter. COVID-19 patients can present with serious and sometimes lethal cardiovascular manifestations of the disease. Patients with severe cases of COVID-19 often suffer ventricular arrhythmias and sudden cardiac death, leading to increased morbidity and mortality, especially for patients with predisposing cardiovascular diseases. There is also substantial clinical evidence of patients experiencing acute myocardial infarctions, which may be caused by either direct damage to the myocardium or from vascular dysfunction that leads to blood clots and ultimately occlusions. Currently, there is significant discussion in the field about whether this cardiac damage is being caused by direct viral infection of the heart or due to systemic inflammatory effects. Many groups have sought to determine whether it is likely that SARS-CoV-2 could directly infect the heart via the ACE2 receptor. SARS-CoV-2 utilizes the ACE2 receptor to bind to cellular membranes and enter susceptible cells. Many groups have performed single-cell RNA-sequencing studies have been performed on human hearts that indicate ACE2 RNA is expressed in multiple cell types in the heart, with pericytes having the highest expression. Pericytes are perivascular cells that are found in abundance in the microvasculature in all vascularized organs where they regulate numerous functions, including vessel growth, permeability, and contractility. Since pericytes play a critical role in supporting endothelial cells and maintaining vascular integrity, we and others hypothesized that pericytes may be a culprit for cardiovascular damage in COVID-19. In healthy vessels, intact endothelial junctions would prevent SARS-CoV-2 was reaching pericytes due to size exclusion. However, if vessels have compromised barriers due to diseases, such as diabetes, SARS-CoV-2 could cross the barrier and infect pericytes, which could then lead to endothelial cell activation and inflammation. This could in turn lead to the coagulopathies and infarcts that are being reported in COVID-19 patients. In my thesis work, I started by collaborating with Dr. Michael Diamond's lab to combine the expertise and resources necessary to study the intrinsic cardiac effects of SARS-CoV-2 in COVID-19. Together, we adapted the Rentschler lab's previously establish human organotypic cardiac slice culture methodology to evaluate cellular tropism of SARS-CoV-2 in explanted donor human hearts rejected from transplantation. We identified cardiac pericytes as a direct target of SARS-CoV-2 infection in organotypic cardiac slices and then collaborated with Dr. Kory Lavine's lab to further evaluate viral entry and downstream effects of infection in primary cardiac pericytes. We found that primary cardiac pericytes were productively infected by SARS-CoV-2; however, we determined that other types of primary human pericytes from other organs, including the brain and placenta, were not infected likely due to significantly lower expression of the main viral entry receptor, ACE2, compared to cardiac pericytes. Furthermore, we determined that viral entry into cardiac pericytes is mediated by endosomal proteases rather than transmembrane serine proteases as seen in the lung epithelium. We demonstrate that cardiac pericyte infection leads to upregulation of Type I interferon signaling, inflammatory markers, and mediators of vasoreactivity, along with NF-[kappa]B cell death, with viability being partially improved by cytokine inhibition. Interestingly, we demonstrate that endothelial cell exposure to infected pericytes and their supernatant can lead to upregulation of Type I interferon signaling and neutrophil and T-cell chemokines combined with dysregulation of thrombosis mediators, further linking infected cardiac pericytes with endothelial dysfunction. And finally, we present evidence of cardiac pericyte infection in COVID-19 myocarditis patients. Together, the results in my thesis work demonstrate that human cardiac pericytes are susceptible to SARS-CoV-2 infection and suggest a role of pericyte infection in COVID-19.
Corona virus disease or COVID-19 or SARS-CoV-2 infection is the latest pandemic that has affected humans globally. The disease has manifested itself in several forms and is now the focus of research worldwide. This book covers all the clinical aspects of the novel corona virus disease, COVID-19, which is one of the most contagious diseases ever known. It includes topics related to basic sciences, such as the virology and pathophysiology of the SARS-CoV-2 disease. It includes chapters related to symptomatology of the disease and making diagnosis, preparation of the health care workers to deal with this global pandemic. The book includes chapters on anesthetic and intensive care management of COVID-19 disease victims as these topics are of vast importance. Additionally, it includes a chapter giving insight in to the ethical aspects of the issues raised regarding disposal of bodies of the victims, as this pandemic has taken many lives across the world. It includes a chapter on special considerations to patient population such as geriatrics, pediatrics and pregnant women. The book serves as a useful resource for practitioners and clinicians in any field of medicine. It is also relevant for residents, trainees, fellows pursuing their courses in emergency medicine, anesthesia and critical care as well as postgraduates and even undergraduates. The book will serve as a ready-reckoner and useful guide for physicians from varied specialties during their clinical practice.
Dunia saat ini sedang menghadapi epidemi severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) yang mengakibatkan outbreak penyakit pernapasan. Setelah lebih dari satu tahun pandemi global ini terjadi, per Juli 2021, setidaknya lebih dari 194 juta kasus dan tidak kurang dari 4 juta kematian dilaporkan di seluruh dunia, termasuk di antaranya 3.082.410 kasus dan 80.598 kematian di Indonesia1,2. Infeksi SARS-CoV-2 terjadi pada semua kelompok umur, tetapi faktor risiko seperti usia yang tua, jenis kelamin pria, dan komorbid penyakit kronis dikaitkan dengan luaran klinis yang buruk.
As the dawn of 2020 arrived, a new threat to Mankind was revealed in the form of- novel Corona Virus, claiming lives incessantly all over the world. Starting in the end of 2019, December, this strain of Corona virus was first isolated from Wuhan, China. The never before identified strain of Corona virus in man, was named as novel Corona virus (2019-nCoV). The infection caused has now been named as Coronavirus Disease 2019 (COVID19). With the physicians still to learn about its behaviour and with no cure at hand, the disease turned into pandemic very soon. World Health Organization instructed all information regarding COVID-19 accessible, so as to doctors and health workers all over the world can use it for better management of the patients globally. Association of Physicians of India has also followed the foot-steps of WHO and has committed itself for the integration of knowledge among the nation and its members regarding COVID-19 through this book Clinical Updates on COVID- 19. As severe forms of the infection have been encountered by the individuals suffering from co-morbidities, this book has addressed Covid 19 infection in such patients with great details. Hope this book will be helpful for all the practicing physicians and resident doctors in combating this Pandemic all over the world.
The book Coronavirus Therapeutics Volume II provides the most comprehensive review on contemporary knowledge on the consequences during the outbreak of Coronavirus. This also describes the clinical features, diagnostic evaluation and management of Coronavirus patients. Using an integrative approach to the understanding of paradigm gap in host-pathogen interaction studies to the management of Coronavirus patients in the Intensive Care Unit to the current challenges for the effective management of Coronavirus pandemic risk factors including diabetes, hypertension, obesity and repercussion on the central and peripheral nervous system. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed articles that review present research activity on the role of heat shock proteins in human diseases and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Cancer Biology, Oncology, Cardiovascular Diseases, Microbiology, Inflammation, Translational Medicine, Clinical Research, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
Umfassende Betrachtung aller wesentlichen Aspekte von COVID-19, insbesondere der Ätiologie, Diagnose, Symptomatologie, Versorgung und Behandlung Coronavirus Disease 2019 (COVID-19): A Clinical Guide bietet Angehörigen der Gesundheitsberufe auf allen Ebenen aktuelle Erkenntnisse über die klinischen, epidemiologischen, genomischen, virologischen und radiologischen Merkmale von COVID-19. Mit diesem umfassenden Lehrwerk werden zahlreiche systematische Übersichten und Meta-Analysen in einem einzigen Band zusammengeführt. Darüber hinaus werden Themen wie gesundheitspolitische Maßnahmen, Notfallpläne für einen Massenanfall von Erkrankten, die Sicherheit des Gesundheitspersonals, die wirtschaftlichen Auswirkungen, die Lehren für künftige Pandemieausbrüche und weitere paraklinische und soziale Aspekte der COVID-19-Pandemie betrachtet. Das Buch bietet eine gründliche Zusammenfassung und kritische Analyse von COVID-19 auf Grundlage einer umfassenden Durchsicht der neuesten veröffentlichten Literatur und Daten. Dargestellt werden die virologischen Eigenschaften von SARS-CoV-2, pulmonale und extrapulmonale Manifestationen und Folgen von COVID-19, die Prävention und Eindämmung der Übertragung, die direkten Auswirkungen der Pandemie auf die Versorgung und Behandlung von Patienten mit anderen Erkrankungen, die passive Immuntherapie und ihre Auswirkungen, Diagnose- und Behandlungsansätze für kritisch erkrankte Patienten und viele weitere Themen. Herausgeber ist ein führender Mediziner, der an der Spitze der COVID-19-Forschung steht. Dieses unverzichtbare Referenzwerk bietet außerdem: * Eine Zusammenführung klinischer, radiologischer und epidemiologischer Daten sowie eine Betrachtung der Prävention, Diagnose und Behandlung * Erörterungen der Epidemiologie, Wirkmechanismen, Erscheinungsformen und Behandlung von kardiovaskulären, neurologischen und pulmonalen Erkrankungen in Verbindung mit COVID-19 * Einen Überblick über die Diagnosetechniken, insbesondere radiologische Bildgebung und RT-PCR-Tests * Eine Analyse der therapeutischen Ansätze zur Behandlung unterschiedlicher Komplikationen * Eine Erörterung der Behandlung von Symptomen nach der Impfung und der Auswirkungen der Immunisierung * Informationen über COVID-19 in der Pädiatrie, bei Krebspatienten sowie bei Patienten mit Lungenerkrankungen, Diabetes, Bluthochdruck, Adipositas und anderen Grunderkrankungen Coronavirus Disease 2019 (COVID-19): A Clinical Guide ist eine unverzichtbare Informationsquelle für Ärzte, Forscher, Epidemiologen, Krankenhauspersonal, Radiologen und Mitarbeiter im Gesundheitswesen, die mit beliebigen Aspekten der COVID-19-Pandemie konfrontiert sind.