[PDF] Apoptosis And Autoimmunity eBook

Author : Keith B. Elkon
Publisher : Karger Medical and Scientific Publishers
Page : 219 pages
File Size : 18,33 MB
Release : 2006
Category : Science
ISBN : 3805580363

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This volume highlights the recent advances in the basic mechanisms of apoptosis and the application of that knowledge to understanding the impact of defective apoptosis or defective clearance of apoptotic cells on the immune function and the expression of

Author : Joachim R. Kalden
Publisher : John Wiley & Sons
Page : 392 pages
File Size : 27,71 MB
Release : 2006-03-06
Category : Medical
ISBN : 3527605290

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This is the first comprehensive book about the relationship between apoptosis and autoimmune diseases. It offers a unique up-to-date overview on research results on the defective execution of apoptosis and the incomplete clearance of apoptotic cells. The molecular and cellular mechanisms involved are described in detail. As a possible consequence of apoptotic dysfunction, the development of severe autoimmune diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus) is discussed. An outlook on future research topics includes the evaluation of novel therapeutic strategies.

Author : Dr. Martin Herrmann
Publisher : Wiley-VCH Verlag GmbH
Page : 381 pages
File Size : 16,6 MB
Release : 2003
Category : Medical
ISBN : 9783527304424

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This is the first comprehensive book about the relationship between apoptosis and autoimmune diseases. It offers a unique up–to–date overview on research results on the defective execution of apoptosis and the incomplete clearance of apoptotic cells. The molecular and cellular mechanisms involved are described in detail. As a possible consequence of apoptotic dysfunction, the development of severe autoimmune diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus) is discussed. An outlook on future research topics includes the evaluation of novel therapeutic strategies.

Author : Andrzej Górski
Publisher : Springer Science & Business Media
Page : 209 pages
File Size : 48,85 MB
Release : 2012-12-06
Category : Medical
ISBN : 9401009813

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This book presents an excellent review of the mechanisms underlying the phenomena of autoimmunity. It provides not only an update of the field's state of the art, but also presents new concepts in the fundamentals and treatment of autoimmune disorders. The finest example of the new approach is understanding the nature of autoimmunity and the treatment of autoimmune diseases is the introductory article. The author opposes the current dogma that autoimmune disorders should be treated with immunosuppressors, and postulates rather the activation of the immune system, which may lead to redirecting the immune response to the protective, Th-2 type of immunity. A series of articles deals with several aspects of the subject, such as the generation, progression, and regulation of autoimmune phenomena. The roles of pathogens, apoptosis, cytokines, complement components, and regulatory T cells are described, as well as the association between the immune and neurohormonal systems in major autoimmune disorders. This is not a textbook, but it is highly recommended for clinicians and university workers, and as supplementary reading for lecturers and students.

Author : Christopher D. Gregory
Publisher : Wiley-Liss
Page : 440 pages
File Size : 12,59 MB
Release : 1995-03-02
Category : Medical
ISBN :

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By offering a broad range of views, Apoptosis and the Immune Response presents a current and complete picture of the various aspects and consequences of this phenomenon.

Author : Kazuwa Nakao
Publisher : Springer
Page : 330 pages
File Size : 29,95 MB
Release : 2015-10-13
Category : Science
ISBN : 4431556516

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This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

Author : M.E. Gershwin
Publisher : Elsevier
Page : 467 pages
File Size : 30,59 MB
Release : 2000-03-27
Category : Medical
ISBN : 0080528457

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Of the two disciplines in parallel development for two decades, tumor immunology and transplantation immunology, the latter has thrived and has led to some of the most critical discoveries in immunobiology. The former continues to thwart both scientists and clinicians alike.The goal of immunologists in modern day research is to develop a simple and effective means to manipulate cancer in vivo, possibly encompassing several venues: identifying a phenotypic marker and the use of either active or passive immunization; include the use of passive reagents carrying "warheads" to selectively destroy cancer cells; or altering the basic process of cell survival.This excellent multidiscipline-authored volume presents a theme which has not been well described before. The papers include both basic and clinical science and range from sophisticated molecular biology to little more than phenomenology (e.g. the increased association of cancer in some autoimmune diseases and increased presentation of autoimmune phenomena in malignant condition). This, however, is state-of-the-art.This collection of themes will be of use not only to bench scientists, but also to clinicians who treat patients. The book represents progress at the cutting edge of this discipline, and points the way to further developments in the "black box" of immunology.

Author : Estee Kurant
Publisher : Frontiers Media SA
Page : 294 pages
File Size : 26,4 MB
Release : 2018-12-27
Category :
ISBN : 2889456889

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Clearance of apoptotic cells is essential for proper development, homeostasis and termination of immune responses in multicellular organisms. Thus, cellular and molecular players taking part in the sequential events of this process are of great interest. Research in the last 20 years has indicated that specific ligands and receptors take part in the attraction of immune cells toward apoptotic targets and in the interactions between apoptotic cells and professional as well as non-professional phagocytes that engulf them. Moreover, phagocytosis of apoptotic cells (efferocytosis) leads to significant phenotypic changes in the engulfing cells suggesting that it is a major fate-determining event for phagocytes. Particularly, efferocytosis has an important impact on the inflammation-resolution axis as well as embryonic development and tissue morphogenesis. Deficiencies in these processes can result in health threats, such as autoimmunity, atherosclerosis, bone loss, obesity, infertility, neurodegeneration, fibrosis and cancer. This eBook brings together 24 original research and review manuscripts that cover various aspects of apoptotic cell removal during normal development and homeostasis as well as in tumorigenesis and regenerative processes following injury.