[PDF] Animal Models Of Speech And Language Disorders eBook

Author : Santosh A. Helekar
Publisher : Springer Science & Business Media
Page : 301 pages
File Size : 42,5 MB
Release : 2013-10-17
Category : Medical
ISBN : 1461484006

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Basic research over the last decade or two has uncovered similarities between speech, especially its sensori-motor aspects, and vocal communication in several non-human species. The most comprehensive studies so far have been conducted in songbirds. Songbirds offer us a model system to study the interactions between developmental or genetic predispositions and tutor-dependent influences, on the learning of vocal communication. Songbird research has elucidated cellular and molecular mechanisms underlying learning and production of vocal patterns, perception of vocal sounds, vocal motor control and vocal neuromotor plasticity. More recently, the entire genome of the songbird zebra finch has been sequenced. These discoveries, along with the identification of several genes implicated in familial human speech and language disorders, have made it possible to look for analogues of speech and language dysfunction in zebra finches, at least at the perceptual and sensori-motor levels. Two approaches in particular have led us closer to the development of animal models of human speech conditions, namely developmental stuttering and a familial verbal dyspraxia associated with a mutation in the gene for the transcription factor FoxP2. Work on other animals that show developmental sensori-motor learning of vocal sounds used for communication have also shown significant progress, leading to the possibility of development of models of speech and language dysfunction in them. Among mammals, the principal ones include dolphins and whales. In non-human primates, while vocal learning per se is not very prominent, investigations on their communicative abilities have thrown some light on the rudiments of language. These considerations make the publication of a book focused on animal models of speech and language disorders, detailing the overall investigative approach of neurobehavioral studies in animals capable of vocal communication and learned vocalizations, a much-needed and worthwhile project. It would serve as a unifying review of research in this new multidisciplinary frontier, spanning the molecular to the behavioral, for clinicians and researchers, as well as a teaching resource for advanced speech pathology and neuroscience students. This book will also be the first of its kind.

Author : Peter Perrino
Publisher :
Page : 0 pages
File Size : 30,38 MB
Release : 2021
Category :
ISBN :

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Among typically developing children, language and communication acquisition occurs rapidly and without formal instruction (i.e., children are not "taught" how to speak). This phenomenon is actually quite remarkable, given that the ability to process, discriminate, and integrate information from multiple sensory, motor, and cognitive domains is essential to establishing speech and language systems. However, effortless language and communication acquisition does not occur for all children. In fact, disruption to any of the core underlying physiological or behavioral processes required for typical language development can cause difficulties and/or delays in acquiring, producing or comprehending language. While it is known that environmental factors influence language and communication development (e.g., deprivation in language input leads to clear delays), genetic influences have also been shown to play a significant role. Indeed, with advancements in genetic screening technology, countless risk genes and loci have been identified and associated with various language-and communication-related neurodevelopmental disorders (NDDs). Experimental study using animal models that allow manipulation of these same genes can provide one approach to demystify genetic contributions to NDDs, including behavioral, physiological, or neuroanatomical outcomes that could inform human pathologies. In the collection of studies presented here we evaluated how genetic manipulations early in development impacted upon neuroanatomy, as well as communicatively-relevant behaviors, in novel as well as previously established transgenic mouse models of language- and communication-NDDs. These transgenic mouse models included: (1) Ush2a heterozygous (HT; implicated in Central auditory processing disorder (CAPD)) and homozygous (KO; implicated in Usher syndrome type 2 (USH2)); (2) Ube3a KO (implicated in Angelman syndrome (AS)); and (3) Kiaa0319 KO (implicated in developmental dyslexia). For each mouse model, we evaluated subjects on a battery of behavioral tasks to measure core underlying behaviors and processes associated with language and communication development (i.e., language-related endophenotypes or "intermediate phenotypes"). These measures included rapid auditory processing, ultrasonic vocalization production, visual perception/discrimination, social interaction, and motor abilities. Additionally, we developed a novel cognitive visual discrimination paradigm aimed to assess higher-order cognitive processing abilities in mice that, in humans, may subserve typical language and communication (e.g., rule-learning and transfer to novel stimuli). Following behavioral testing, we performed comprehensive histological assessments on subjects with manipulations of Ush2a and Kiaa0319 to ascertain whether mutations in these genes also led to alterations in brain development, and whether such disruptions contributed to associated behavioral impairments. Together, our findings shed light on the underlying genetic contributions to language and communication acquisition and development. Ongoing and future research may aid in early genetic screening and associated diagnosis, prognosis, and tailoring of interventions that might help to ameliorate communication and language disorders in humans.

Author : Michael Christopher Condro
Publisher :
Page : 254 pages
File Size : 10,62 MB
Release : 2013
Category :
ISBN :

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Language is a complex communicative behavior unique to humans, though its genetic basis is still poorly understood. Genes associated with human speech and language disorders have provided a basis for study, originating with the FOXP2 transcription factor, a mutation in which is the source of an inherited form of developmental verbal dyspraxia. Subsequently, targets of FOXP2 regulation have been investigated for their associations with language-related disorders. One such target, contactin associated protein-like 2 (CNTNAP2), is associated with autism and specific language impairment. Due to the exclusivity of language to humans, no single animal model is sufficient to study the complete behavioral effects of these genes. However, some animals do possess components of language. One such component is vocal learning, which though rare in the animal kingdom, is shared with songbirds. Here, I use the zebra finch songbird as an animal model to investigate the role of Cntnap2 in birdsong. Cntnap2 is enriched in several song production nuclei in the zebra finch brain, including the striatopallidal nucleus area X, and the cortical lateral magnocellular nucleus of the anterior nidopallium and the robust nucleus of the arcopallium (RA). In adult RA, the distribution of Cntnap2 protein corresponds to the sexually dimorphic singing behavior of this species: males sing, and have enrichment of Cntnap2-expressing neurons, whereas females display neither the behavior nor the enrichment. In juveniles, however, there is comparable enrichment in RA in both sexes until the onset of sensorimotor learning in males, at which time the percentage of Cntnap2-expressing neurons in female RA declines. The neurons in RA that express Cntnap2 are projection neurons that directly innervate the motor neurons that control the vocal organ, analogous to human layer 5 pyramidal neurons of the primary motor cortex that innervate the motor neurons of the larynx. To test the function of Cntnap2 in zebra finch song, I designed and tested RNA interference constructs, which can be used to knock down Cntnap2 in RA. The songbird model can be used to understand the impact of Cntnap2 and other vocal learning genes as they relate to human speech and language.

Author : Georgios P. D. Argyropoulos
Publisher : Springer Nature
Page : 300 pages
File Size : 41,40 MB
Release : 2020-02-27
Category : Medical
ISBN : 3030356876

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This book provides the first presentation of the state-of-the-art in the application of modern Neuroscience research in predicting, preventing and alleviating the negative sequelae of neurodevelopmental, acquired, or neurodegenerative brain abnormalities on speech and language. To this end, this edited volume brings together contributions from several leading experts in a markedly broad range of disciplines, comprising Neurology, Neurosurgery, Genetics, Engineering, Neuroimaging and Neurostimulation, Neuropsychology, and Speech and Language Therapy.

Author : Gene S. Fisch
Publisher : Springer Science & Business Media
Page : 295 pages
File Size : 26,87 MB
Release : 2007-11-06
Category : Medical
ISBN : 1597450588

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In this up-to-date survey and critical assessment of transgenic and knockout models in neuropsychiatry and behavior, a panel of leading researchers comprehensively assesses how and whether the genetic abnormalities produced from these models manifest the neuropsychiatric disorders to which they correspond. The authors focus on transgenic and knockout models of neurocognitive dysfunction and neuropsychiatric dysfunction. The discussion of neurobiological problems covers mental retardation, polyglutamate, and speech disorders, as well as disorders that involve cognitive, social, speech, and language dysfunction. The neuropsychiatric dysfunctions examined include psychosis and schizophrenia, anxiety, depression, and bipolar disorder.

Author : Stefan M Brudzynski
Publisher : Academic Press
Page : 582 pages
File Size : 10,52 MB
Release : 2018-04-27
Category : Science
ISBN : 0128097736

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Handbook of Ultrasonic Vocalization: Window into the Mammalian Brain, Volume 25, is an exhaustive resource on ultrasonic vocalizations in vertebrates, providing full coverage of all aspects of these vocalizations. The book also demonstrates the usefulness of ultrasonic vocalizations in studies of animal communication, sociobiological states, and in mammalian models of affective disorders, addictions and neurodevelopmental disorders, making it an indispensable resource for researchers using animal models. The book begins with the evolution of vocal communication before discussing mechanisms of ultrasound production, perception and the brain systems involved in emotional arousal that are responsible for the generation of vocalization and emotional states. In addition, the book covers studies of neuroactive agents and sociopsychological conditions that can regulate the outcome of ultrasonic vocalization and provide clues about animals’ internal states. Critically, the book also includes thorough coverage of pharmacological investigations using ultrasonic vocalizations, increasingly being utilized for studies in affective disorders, psychoses, addiction and alcoholism. No other book provides such extensive coverage of this rapidly growing field of study. Represents a multidisciplinary approach that incorporates evolution, communication, behavioral homeostasis, emotional expression and neuropsychiatric dysfunction Provides a systematic review of ultrasonic vocalizations in major groups of rodents widely used in laboratory research Discusses numerous other species across vertebrates that emit ultrasounds

Author : Maria Mody
Publisher : Springer
Page : 227 pages
File Size : 10,52 MB
Release : 2017-10-24
Category : Psychology
ISBN : 1493973258

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This important volume brings together significant findings on the neural bases of spoken language –its processing, use, and organization, including its phylogenetic roots. Employing a potent mix of conceptual and neuroimaging-based approaches, contributors delve deeply into specialized structures of the speech system, locating sensory and cognitive mechanisms involved in listening and comprehension, grasping meanings and storing memories. The novel perspectives revise familiar models by tracing linguistic interactions within and between neural systems, homing in on the brain’s semantic network, exploring the neuroscience behind bilingualism and multilingual fluency, and even making a compelling case for a more nuanced participation of the motor system in speech. From these advances, readers have a more three-dimensional picture of the brain—its functional epicenters, its connections, and the whole—as the seat of language in both wellness and disorders. Included in the topics: · The interaction between storage and computation in morphosyntactic processing. · The role of language in structure-dependent cognition. · Multisensory integration in speech processing: neural mechanisms of cross-modal after-effect. · A neurocognitive view of the bilingual brain. · Causal modeling: methods and their application to speech and language. · A word in the hand: the gestural origins of language. Neural Mechanisms of Language presents a sophisticated mix of detail and creative approaches to understanding brain structure and function, giving neuropsychologists, cognitive neuroscientists, developmental psychologists, cognitive psychologists, and speech/language pathologists new windows onto the research shaping their respective fields.

Author : David Pisoni
Publisher : John Wiley & Sons
Page : 704 pages
File Size : 47,75 MB
Release : 2008-04-15
Category : Language Arts & Disciplines
ISBN : 0470756772

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The Handbook of Speech Perception is a collection of forward-looking articles that offer a summary of the technical and theoretical accomplishments in this vital area of research on language. Now available in paperback, this uniquely comprehensive companion brings together in one volume the latest research conducted in speech perception Contains original contributions by leading researchers in the field Illustrates technical and theoretical accomplishments and challenges across the field of research and language Adds to a growing understanding of the far-reaching relevance of speech perception in the fields of phonetics, audiology and speech science, cognitive science, experimental psychology, behavioral neuroscience, computer science, and electrical engineering, among others.

Author : Jonathan C. Gewirtz
Publisher : Springer
Page : 395 pages
File Size : 46,15 MB
Release : 2016-08-10
Category : Medical
ISBN : 1493937774

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This stimulating analysis reviews the broad potential of animal models to foster a deeper understanding of human pathology, strengthen connections between genetic and behavioral studies, and develop more effective treatments for mental disorders. Widely-studied and lesser-used species are examined in models that capture features along the continuum of normative and pathological behavior. The models highlight genetic causes of core features, or endophenotypes, of developmental, internalizing, and externalizing disorders, as well as dementia. Expert contributors address questions ranging from how suitable species are chosen for study to the costs and benefits of using inbred versus outbred strains, and the effects of housing environment on subject animals. Larger issues addressed include how to evaluate the applicability of animal behavioral models to the human condition and how these models can harness emerging molecular technologies to further our understanding of the genetic basis of mental illness. Included in the coverage: Mating and fighting in Drosophila. Attachment and social bonding. Impulsivity in rodents and humans. Animal models of cognitive decline. Animal models of social cognition. Future directions for animal models in behavioral genetics. A detailed map of where this evolving field is headed, Animal Models of Behavior Genetics shows geneticists, molecular biologists, and cognitive neuroscientists paths beyond established concepts toward a more knowledgeable and collaborative future.