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Author : Palmer, Lyle J.
Publisher : Policy Press
Page : 240 pages
File Size : 14,84 MB
Release : 2011-05-31
Category : Medical
ISBN : 1861348975
This book brings together leading experts to provide an introduction to genetic epidemiology that begins with a primer in human molecular genetics through all the standard methods in population genetics and genetic epidemiology required for an adequate grounding in the field.
Author : Melissa A. Austin
Publisher : CABI
Page : 223 pages
File Size : 50,91 MB
Release : 2013
Category : Medical
ISBN : 1780641818
Genetic epidemiology plays a key role in discovering genetic factors influencing health and disease, and in understanding how genes and environmental risk factors interact. There is growing interest in this field within public health, with the goal of translating the results into promoting health and preventing disease in both families and populations. This textbook provides graduate students with a working knowledge of genetic epidemiology research methods. Following an overview of the field, the book reviews key genetic concepts, provides an update on relevant genomic technology, including genome-wide chips and DNA sequencing, and describes methods for assessing the magnitude of genetic influences on diseases and risk factors. The book focuses on research study designs for discovering disease susceptibility genes, including family-based linkage analysis, candidate gene and genome-side association studies, assessing gene-environment interactions and epistasis, studies of Non-Mendelian inheritance, and statistical analyses of data from these studies. Specific applications of each research method are illustrated using a variety of diseases and risk factors relevant to public health, and useful web-based genetic analysis software, human reference panels, and repositories, that can greatly facilitate this work, are described.
Author : Muin J. Khoury
Publisher : Monographs in Epidemiology and
Page : 394 pages
File Size : 22,83 MB
Release : 1993
Category : Medical
ISBN : 0195052889
This text integrates the principles, methods and approaches of epidemiology and genetics in the study of disease aetiology. The authors define the central theme of genetic epidemiology as the study of the role of genetic factors and their interaction with environmental factors in the occurrence of disease in populations.
Author : Andreas Ziegler
Publisher : John Wiley & Sons
Page : 522 pages
File Size : 11,81 MB
Release : 2011-08-24
Category : Science
ISBN : 3527633669
A Statistical Approach to Genetic Epidemiology After studying statistics and mathematics at the University of Munich and obtaining his doctoral degree from the University of Dortmund, Andreas Ziegler received the Johann-Peter-Süssmilch-Medal of the German Association for Medical Informatics, Biometry and Epidemiology for his post-doctoral work on “Model Free Linkage Analysis of Quantitative Traits” in 1999. In 2004, he was one of the recipients of the Fritz-Linder-Forum-Award from the German Association for Surgery.
Author : Robert C. Elston
Publisher : John Wiley & Sons
Page : 860 pages
File Size : 12,2 MB
Release : 2002-04-22
Category : Medical
ISBN : 9780471486312
"Human Genetics and Genetic Epidemiology" ist der 3. Band aus der sehr erfolgreichen Reihe 'Wiley Biostatistics Reference Series', die auf Artikeln der "Encyclopedia of Biostatistics" basiert. Dieser Band gibt einen topaktuellen und umfassenden Überblick über ein Forschungsgebiet, das insbesondere im Zuge des Human-Genomprojekts eine regelrechte Explosion an Forschungsaktivitäten erlebt hat. Enthalten sind komplett aktualisierte Artikel aus der "Encyclopedia of Biostatistics" sowie über 25% neue Artikel. Mit einem komplexen System an Querverweisen, die das Auffinden der gewünschten Information erheblich erleichtern. Eine interessante Lektüre für Genetiker, Epidemiologen, Biostatistiker und Forscher in diesen Bereichen.
Author : Wilcox
Publisher :
Page : pages
File Size : 30,78 MB
Release : 2005-02-01
Category :
ISBN : 9780763783594
Author : Evangelos Evangelou
Publisher : Humana Press
Page : 299 pages
File Size : 37,85 MB
Release : 2018-06-07
Category : Medical
ISBN : 9781493978670
This volume details fast-moving research while providing in-depth descriptions of methods and analytical approaches that are helping to understand the genome and how it is related to complex diseases. Chapters guide the reader through common and rare variation, gene-gene and gene-environment interactions and state-of-the-art approaches for the synthesis of genome-wide and gene expression data. Novel approaches for associations in the HLA region, family-based designs, Mendelian Randomization and Copy Number Variation are also presented. The volume concludes with the challenges researchers face while moving from identifying variants to their functional role and potential drug targets. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, a thorough presentation of methods and approaches and tips on troubleshooting and avoiding known pitfalls.
Author : Melinda C. Mills
Publisher : MIT Press
Page : 433 pages
File Size : 39,19 MB
Release : 2020-02-18
Category : Science
ISBN : 0262538385
A comprehensive introduction to modern applied statistical genetic data analysis, accessible to those without a background in molecular biology or genetics. Human genetic research is now relevant beyond biology, epidemiology, and the medical sciences, with applications in such fields as psychology, psychiatry, statistics, demography, sociology, and economics. With advances in computing power, the availability of data, and new techniques, it is now possible to integrate large-scale molecular genetic information into research across a broad range of topics. This book offers the first comprehensive introduction to modern applied statistical genetic data analysis that covers theory, data preparation, and analysis of molecular genetic data, with hands-on computer exercises. It is accessible to students and researchers in any empirically oriented medical, biological, or social science discipline; a background in molecular biology or genetics is not required. The book first provides foundations for statistical genetic data analysis, including a survey of fundamental concepts, primers on statistics and human evolution, and an introduction to polygenic scores. It then covers the practicalities of working with genetic data, discussing such topics as analytical challenges and data management. Finally, the book presents applications and advanced topics, including polygenic score and gene-environment interaction applications, Mendelian Randomization and instrumental variables, and ethical issues. The software and data used in the book are freely available and can be found on the book's website.
Author : Duncan C. Thomas
Publisher : Oxford University Press
Page : 458 pages
File Size : 36,58 MB
Release : 2004-01-29
Category : Medical
ISBN : 0199748055
This well-organized and clearly written text has a unique focus on methods of identifying the joint effects of genes and environment on disease patterns. It follows the natural sequence of research, taking readers through the study designs and statistical analysis techniques for determining whether a trait runs in families, testing hypotheses about whether a familial tendency is due to genetic or environmental factors or both, estimating the parameters of a genetic model, localizing and ultimately isolating the responsible genes, and finally characterizing their effects in the population. Examples from the literature on the genetic epidemiology of breast and colorectal cancer, among other diseases, illustrate this process. Although the book is oriented primarily towards graduate students in epidemiology, biostatistics and human genetics, it will also serve as a comprehensive reference work for researchers. Introductory chapters on molecular biology, Mendelian genetics, epidemiology, statistics, and population genetics will help make the book accessible to those coming from one of these fields without a background in the others. It strikes a good balance between epidemiologic study designs and statistical methods of data analysis.
Author : Jørn Olsen
Publisher : Springer Science & Business Media
Page : 152 pages
File Size : 13,69 MB
Release : 2010-06-14
Category : Medical
ISBN : 1441914978
Today, the public worries about emerging diseases and rapid changes of the frequency of well known diseases like autism, diabetes and obesity making the word epidemic part of the general discussion. Epidemiology should therefore be a basic component of medical training, yet often it is undertaught or even neglected. Concise and readable while also rigorous and thorough, An Introduction to Epidemiology for Health Professionals goes beyond standard textbook content to ground the reader in scientific methods most relevant to the current health landscape and the evolution of evidence-based medicine—valuable keys to better understanding of disease process, effective prevention, and targeted treatment.