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Though originally attributed to his father, Jules Verne, due to an error on the part of the publisher, the short tale "An Express of the Future" was actually penned by Jules Verne's often-estranged son, Michel. The story is remarkable in its prescient description of future technologies, such as pneumatic tubes.
A surprisingly hopeful assessment of the prospects for human rights in the Middle East, and a blueprint for advancing them The enormous sense of optimism unleashed by the Arab Spring in 2011 soon gave way to widespread suffering and despair. Of the many popular uprisings against autocratic regimes, Tunisia’s now stands alone as a beacon of hope for sustainable human rights progress. Libya is a failed state; Egypt returned to military dictatorship; the Gulf States suppressed popular protests and tightened control; and Syria and Yemen are ravaged by civil war. Challenging the widely shared pessimism among regional experts, Micheline Ishay charts bold and realistic pathways for human rights in a region beset by political repression, economic distress, sectarian conflict, a refugee crisis, and violence against women. With due attention to how patterns of revolution and counterrevolution play out in different societies and historical contexts, Ishay reveals the progressive potential of subterranean human rights forces and offers strategies for transforming current realities in the Middle East.
This major new manifesto offers a “clear and compelling vision of a postcapitalist society” and shows how left-wing politics can be rebuilt for the 21st century (Mark Fisher, author of Capitalist Realism) Neoliberalism isn’t working. Austerity is forcing millions into poverty and many more into precarious work, while the left remains trapped in stagnant political practices that offer no respite. Inventing the Future is a bold new manifesto for life after capitalism. Against the confused understanding of our high-tech world by both the right and the left, this book claims that the emancipatory and future-oriented possibilities of our society can be reclaimed. Instead of running from a complex future, Nick Srnicek and Alex Williams demand a postcapitalist economy capable of advancing standards, liberating humanity from work and developing technologies that expand our freedoms. This new edition includes a new chapter where they respond to their various critics.
Stroke remains one of the most devastating diseases in industrialized countries. Recanalization of the occluded arterial vessel using thrombolysis is the only causal therapy available. However, thrombolysis is limited due to severe side effects and a limited time window. As such, only a minority of patients receives this kind of therapy, showing a need for new and innovative treatment strategies. Although neuroprotective drugs have been shown to be beneficial in a variety of experimental stroke models, they ultimately failed in clinical trials. Consequently, recent scientific focus has been put on modulation of post-ischemic neuroregeneration, either via stimulation of endogenous neurogenesis or via application of exogenous stem cells or progenitor cells. Neurogenesis persists within the adult brain of both rodents and primates. As such, neural progenitor cells (NPCs) are found within distinct niches like the subventricular zone (SVZ) of the lateral ventricles and the subgranular zone of the dentate gyrus. Cerebral ischemia stimulates these astrocyte-like progenitor cells, upon which NPCs proliferate and migrate towards the site of lesion. There, NPCs partly differentiate into mature neurons, without significantly being integrated into the residing neural network. Rather, the majority of new-born cells dies within the first weeks post-stroke, leaving post-ischemic neurogenesis a phenomenon of unknown biological significance. Since NPCs do not replace lost brain tissue, beneficial effects observed in some studies after either stimulated or protected neurogenesis are generally contributed to indirect effects of these new-born cells. The precise identification of appropriated cellular mediators, however, is still elusive. How do these mediators work? Are they soluble factors or maybe even vesicular structures emanating from NPCs? What are the cues that guide NPCs towards the ischemic lesion site? How can post-ischemic neurogenesis be stimulated? How can the poor survival of NPCs be increased? In order to support post-ischemic neurogenesis, a variety of research groups have focused on application of exogenous stem/progenitor cells from various tissue sources. Among these, cultivated NPCs from the SVZ and mesenchymal stem cells (MSCs) from the bone marrow are frequently administered after induction of stroke. Although neuroprotection after delivery of stem/progenitor cells has been shown in various experimental stroke models, transplanted cells are usually not integrated in the neural network. Again, the vast amount of grafted cells dies or does not reach its target despite profound neuroprotection, also suggesting indirect paracrine effects as the cause of neuroprotection. Yet, the factors being responsible for these observations are under debate and still have to be addressed. Is there any “optimal” cell type for transplantation? How can the resistance of grafted cells against a non-favorable extracellular milieu be increased? What are the molecules that are vital for interaction between grafted cells and endogenous NPCs? The present research topic seeks to answer - at least in part - some of the aforementioned questions. Although the research topic predominantly focuses on experimental studies (and reviews alike), a current outlook towards clinical relevance is given as well.
It is difficult to find an area of public policy more plagued by misunderstanding than energy policy. Even worse, every time the subject is raised, we are obligated to get mired in pointless arguments about the weather. This book helps set the record straight. Not convinced? Consider some of these inconvenient truths: The cost of green energy climate remediation is anywhere from 10-to-1,000 times greater than the damage from the climate change it attempts to alleviate. Germany, the worlds leader in solar energy, will spend more than $280 billion by 2030 on solar subsidies. But all of that investment will only forestall 22nd century global warming by 37 hours. Obamas carbon tax would cost Americans $1.2 trillion over just ten years. But it would only reduce the midrange 3 degree modeled 22nd century global temperature increase by 0.038 degrees Celsius. At their current emissions growth rate, it will take China nine months to replace the entire U.S. emissions cut that Obama wants to achieve over seven years, at a staggering cost in American jobs and lost economic growth. The U.S. biofuel program imposes a cost on consumers 9,862 times greater than any climate benefit they or their distant progeny will ever derive. This is not another skeptical global warming polemic but an economic evaluation of how and why green energy will fail. The world has too many pressing needs. For the money Obama squandered on just a single bankrupt crony solar company, the U.S. could have prevented 300,000 childhood malaria deaths in poor countries. A thoroughly researched, heavily documented book by an expert in his field, it will demonstrate in meticulous detail how wasteful and economically inefficient Obamas green energy dead end future will be compared to other worthy alternatives. Its time to end the hysterical climate cynicism and get on humanitys side.