[PDF] Altered On Impact eBook

Author : Siobhan Banks
Publisher : MDPI
Page : 183 pages
File Size : 13,53 MB
Release : 2018-03-13
Category : Health & Fitness
ISBN : 3038427594

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This book is a printed edition of the Special Issue "The Impact of Altered Timing of Eating, Sleep and Work Patterns on Human Health" that was published in Nutrients

Author : Lynn Delgaudio
Publisher : Lynn Delgaudio
Page : 198 pages
File Size : 25,12 MB
Release : 2019-04-15
Category :
ISBN : 9780578472713

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ALTERED ON IMPACT is the true life account of Lynn DelGaudio's experience healing from a traumatic brain injury. Through her journey, DelGaudio discovered that she would need to completely redesign her mind or lose everything. Her inspiring story is not only a tale of resilience, courage and persistence, but DelGaudio also shares specific exercises and step-by-step instructions to help others enact their own mind redesign. This book is for you if: - you've suffered any sort of traumatic brain injury.- you are looking for inspiration to change your thinking.- you want to create abundance and opportunity in your life.Altered on Impact teaches us that tragedy doesn't define you, but your commitment to a better life does.

Author : Valerie Sperling
Publisher : Cambridge University Press
Page : 397 pages
File Size : 47,80 MB
Release : 2009-05-25
Category : Political Science
ISBN : 0521834007

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Is globalization good for democracy? This book examines the accountability of transnational institutions and traces their impact on democratic governance.

Author : Julia Adeney Thomas
Publisher : Cambridge University Press
Page : 297 pages
File Size : 10,53 MB
Release : 2022-03-31
Category : History
ISBN : 1009050672

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Altered Earth aims to get the Anthropocene right in three senses. With essays by leading scientists, it highlights the growing consensus that our planet entered a dangerous new state in the mid-twentieth century. Second, it gets the Anthropocene right in human terms, bringing together a range of leading authors to explore, in fiction and non-fiction, our deep past, global conquest, inequality, nuclear disasters, and space travel. Finally, this landmark collection presents what hope might look like in this seemingly hopeless situation, proposing new political forms and mutualistic cities. 'Right' in this book means being as accurate as possible in describing the physical phenomenon of the Anthropocene; as balanced as possible in weighing the complex human developments, some willed and some unintended, that led to this predicament; and as just as possible in envisioning potential futures.

Author : Thomas M. Holbrook
Publisher : Oxford University Press
Page : 224 pages
File Size : 41,25 MB
Release : 2016-05-30
Category : Political Science
ISBN : 0190269154

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The 2012 presidential elections represented the second consecutive defeat for the Republican Party, and its fourth defeat out of the last six presidential elections. In recent years both Republican and Democratic strategists and pundits have spoken of an emerging Democratic Party "lock" on the Electoral College and speculated that even in the wake of Republican victories in Congress, presidential candidates are still at a major disadvantage due to the party's increasing demographic and geographic isolation. In Altered States, Thomas Holbrook looks at change in party fortunes in presidential elections since 1972, documenting the magnitude, direction, and consequences of changes in party support in the states. He finds that the Democrats do not have a "lock" on the Electoral College, but that their position has improved dramatically over the past forty years in a number of formerly competitive or Republican-leaning states in the Northeast, Southeast, and Southwest. Republican candidates have made many fewer gains, mostly improving their position in "misplaced," formerly Democratic states, such as Kentucky and West Virginia, or in already deeply Republican states in the Plains and Mountain West. Holbrook looks at the ways that changes in the racial and ethnic composition of the state electorates, internal (state to state) and external (foreign born) migratory patterns, and changes in other key demographic and political characteristics drive these changes. Additionally, he explores the ways in which increasing partisan polarization at the national level has altered group-based party linkages and contributed to changes in party support at the state level. These factors, along with an increasingly inefficient distribution of Republican votes, have converted what was once a Republican edge in electoral votes to an advantage for Democratic presidential candidates.

Author : Anna Powell
Publisher : Edinburgh University Press
Page : 224 pages
File Size : 28,94 MB
Release : 2012-02-20
Category : Performing Arts
ISBN : 0748689508

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This book offers a typology of altered states, defining dream, hallucination, trance, vision and ecstasy in their cinematic expression.

Author : Manoj Kumar Jaiswal
Publisher : Frontiers Media SA
Page : 338 pages
File Size : 36,33 MB
Release : 2017-04-17
Category :
ISBN : 2889451461

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Amyotrophic lateral sclerosis (ALS) is a rapidly progressive, devastating and fatal disease characterized by selective loss of upper and lower motor neurons of the cerebral cortex, brainstem, spinal cord and muscle atrophy. In spite of many years of research, the pathogenesis of ALS is still not well understood. ALS is a multifaceted genetic disease, in which genetic susceptibility to motor neuron death interacts with environmental factors and there is still no cure for this deleterious disease. At present, there is only one FDA approved drug, Riluzole which according to past studies only modestly slows the progression of the disease, and improves survival by up to three months. The suffering of the ALS patients, and their families is enormous and the economic burden is colossal. There is therefore a pressing need for new therapies. Different molecular pathways and pathological mechanisms have been implicated in ALS. According to past studies, altered calcium homeostasis, abnormal mitochondrial function, protein misfolding, axonal transport defects, excessive production of extracellular superoxide radicals, glutamate-mediated excitotoxicity, inflammatory events, and activation of oxidative stress pathways within the mitochondria and endoplasmic reticulum can act as major contributor that eventually leads to loss of connection between muscle and nerve ultimately resulting to ALS. However, the detailed molecular and cellular pathophysiological mechanisms and origin and temporal progression of the disease still remained elusive. Ongoing research and future advances will likely advance our improve understanding about various involved pathological mechanism ultimately leading to discoveries of new therapeutic cures. Importantly, clinical biomarkers of disease onset and progression are thus also urgently needed to support the development of the new therapeutic agents and novel preventive and curative strategies. Effective translation from pre-clinical to clinical studies will further require extensive knowledge regarding drug activity, bioavailability and efficacy in both the pre-clinical and clinical setting, and proof of biological activity in the target tissue. During the last decades, the development of new therapeutic molecules, advance neuroimaging tools, patient derived induced stem cells and new precision medicine approaches to study ALS has significantly improved our understanding of disease. In particular, new genetic tools, neuroimaging methods, cellular probes, biomarker study and molecular techniques that achieve high spatiotemporal resolution have revealed new details about the disease onset and its progression. In our effort to provide the interested reader, clinician and researchers a comprehensive summaries and new findings in this field of ALS research, hereby we have created this electronic book which comprises of twenty seven chapters having various reviews, perspective and original research articles. All these chapters and articles in this book not only summarize the cutting-edge techniques, approaches, cell and animal models to study ALS but also provide unprecedented coverage of the current developments and new hypothesis emerging in ALS research. Some examples are novel genetic and cell culture based models, mitochondria-mediated therapy, oxidative stress and ROS mechanism, development of stem cells and mechanism-based therapies as well as novel biomarkers for designing and testing effective therapeutic strategies that can benefit ALS patients who are at the earlier stages in the disease. I am extremely grateful to all the contributors to this book and want to thank them for their phenomenal efforts. Manoj Kumar Jaiswal, Ph.D. February 5, 2017 New York, NY