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A Sub-grouping Methodology and Non-parametric Sequential Ratio Test for Signal Validation

Author : Chenggang Yu
Publisher :
Page : pages
File Size : 25,20 MB
Release : 2002
Category :
ISBN :

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On-line signal validation is essential for safe and economic operations of a complicated industrial system such as a nuclear power plant. Various signal validation methods based on empirical signal estimation have been developed and successfully used. The first part of the thesis addresses a common and unavoidable problem for these methods -fault propagation, which causes false identification of healthy signals as faulty ones because of the faults existing in other signals. This effect is especially serious when faults occur in multiple signals and/or during system transient. A sub-grouping technique is presented in the thesis to prevent the effect of fault propagation in general signal validation methods. Specifically, two methods, Subgroups Consistency Check (SCC) and Subgroups Voting (SV), are developed. Their effectiveness is demonstrated by using a well-known Multivariate State Estimation technique (MSET) as a general method of signal estimation. To further improve the performance of MSET estimation, a procedure called Feedback Once (FBO) is also developed. All these new methods are tested and compared with MSET by using real transient data from a reactor startup process in a nuclear power plant. The results show that false identification of signals caused by fault propagation is significantly reduced by the two sub-grouping methods and the FBO method is able to improve the performance of MSET estimation to some extent. The results demonstrate that implementation of these new methods can lead to an improved signal validation technique that remains effective even when faults occur in multiple signals during system transients. The other major contribution is on the improvement of statistical test used for signal validation. Sequential Probability Ratio Test (SPRT) is a popular method that has been widely used in many signal validation methods. However, the assumption of SPRT is too stringent to satisfy in practice, which may cause the false identification rate exceeding the preset tolerance. In this thesis, a Sequential Rank-sum Probability Ratio Test (SRPRT) method is developed. This method is similar to SPRT in procedure but is based on a much weaker assumption that can be easily satisfied. The demonstrations show that SRPRT yields a smaller false identification rate than SPRT and is always below the preset tolerance.

Cochrane Handbook for Systematic Reviews of Interventions

Author : Julian P. T. Higgins
Publisher : Wiley
Page : 672 pages
File Size : 34,17 MB
Release : 2008-11-24
Category : Medical
ISBN : 9780470699515

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Healthcare providers, consumers, researchers and policy makers are inundated with unmanageable amounts of information, including evidence from healthcare research. It has become impossible for all to have the time and resources to find, appraise and interpret this evidence and incorporate it into healthcare decisions. Cochrane Reviews respond to this challenge by identifying, appraising and synthesizing research-based evidence and presenting it in a standardized format, published in The Cochrane Library (www.thecochranelibrary.com). The Cochrane Handbook for Systematic Reviews of Interventions contains methodological guidance for the preparation and maintenance of Cochrane intervention reviews. Written in a clear and accessible format, it is the essential manual for all those preparing, maintaining and reading Cochrane reviews. Many of the principles and methods described here are appropriate for systematic reviews applied to other types of research and to systematic reviews of interventions undertaken by others. It is hoped therefore that this book will be invaluable to all those who want to understand the role of systematic reviews, critically appraise published reviews or perform reviews themselves.

Encyclopaedia of Mathematics

Author : Michiel Hazewinkel
Publisher : Springer Science & Business Media
Page : 743 pages
File Size : 30,82 MB
Release : 2013-12-01
Category : Mathematics
ISBN : 9400903650

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This ENCYCLOPAEDIA OF MATHEMATICS aims to be a reference work for all parts of mathe matics. It is a translation with updates and editorial comments of the Soviet Mathematical Encyclopaedia published by 'Soviet Encyclopaedia Publishing House' in five volumes in 1977-1985. The annotated translation consists of ten volumes including a special index volume. There are three kinds of articles in this ENCYCLOPAEDIA. First of all there are survey-type articles dealing with the various main directions in mathematics (where a rather fine subdivi sion has been used). The main requirement for these articles has been that they should give a reasonably complete up-to-date account of the current state of affairs in these areas and that they should be maximally accessible. On the whole, these articles should be understandable to mathematics students in their first specialization years, to graduates from other mathematical areas and, depending on the specific subject, to specialists in other domains of science, en gineers and teachers of mathematics. These articles treat their material at a fairly general level and aim to give an idea of the kind of problems, techniques and concepts involved in the area in question. They also contain background and motivation rather than precise statements of precise theorems with detailed definitions and technical details on how to carry out proofs and constructions. The second kind of article, of medium length, contains more detailed concrete problems, results and techniques.

Proceedings of the 23rd Pacific Basin Nuclear Conference, Volume 2

Author : Chengmin Liu
Publisher : Springer Nature
Page : 1238 pages
File Size : 12,50 MB
Release : 2023-05-16
Category : Science
ISBN : 9811987807

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“This is the second in a series of three volumes of proceedings of the 23rd Pacific Basin Nuclear Conference (PBNC 2022) which was held by Chinese Nuclear Society. As one in the most important and influential conference series of nuclear science and technology, the 23rd PBNC was held in Beijing and Chengdu, China in 2022 with the theme “Nuclear Innovation for Zero-carbon Future”. For taking solid steps toward the goals of achieving peak carbon emissions and carbon neutrality, future-oriented nuclear energy should be developed in an innovative way for meeting global energy demands and coordinating the deployment mechanism. It brought together outstanding nuclear scientists and technical experts, senior industry executives, senior government officials and international energy organization leaders from all across the world. The proceedings highlight the latest scientific, technological and industrial advances in Nuclear Safety and Security, Operations and Maintenance, New Builds, Waste Management, Spent Fuel, Decommissioning, Supply Capability and Quality Management, Fuel Cycles, Digital Reactor and New Technology, Innovative Reactors and New Applications, Irradiation Effects, Public Acceptance and Education, Economics, Medical and Biological Applications, and also the student program that intends to raise students’ awareness in fully engaging in this career and keep them updated on the current situation and future trends. These proceedings are not only a good summary of the frontiers in nuclear science and technology, but also a useful guideline for the researchers, engineers and graduate students.

Practical Aspects of Signal Detection in Pharmacovigilance

Author : Council for International Organizations of Medical Sciences (CIOMS)
Publisher : Cioms
Page : 0 pages
File Size : 34,6 MB
Release : 2010
Category : Drug monitoring
ISBN : 9789290360827

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In recent years public expectations for rapid identification and prompt management of emerging drug safety issues have grown swiftly. Over a similar timeframe, the move from paper-based adverse event reporting systems to electronic capture and rapid transmission of data has resulted in the accrual of substantial datasets capable of complex analysis and querying by industry, regulators and other public health organizations. These two drivers have created a fertile environment for pharmacovigilance scientists, information technologists and statistical experts, working together, to deliver novel approaches to detect signals from these extensive and quickly growing datasets, and to manage them appropriately. In following this exciting story, this report looks at the practical consequences of these developments for pharmacovigilance practitioners. The report provides a comprehensive resource for those considering how to strengthen their pharmacovigilance systems and practices, and to give practical advice. But the report does not specify instant solutions. These will inevitably be situation specific and require careful consideration taking into account local needs. However, the CIOMS Working Group VIII is convinced that the combination of methods and a clear policy on the management of signals will strengthen current systems. Finally, in looking ahead, the report anticipates a number of ongoing developments, including techniques with wider applicability to other data forms than individual case reports. The ultimate test for pharmacovigilance systems is the demonstration of public health benefit and it is this test which signal detection methodologies need to meet if the expectations of all stakeholders are to be fulfilled.

Sequential Tests of Statistical Hypotheses

Author : Bhaskar Kumar Ghosh
Publisher :
Page : 472 pages
File Size : 19,79 MB
Release : 1970
Category : Sequences (Mathematics)
ISBN :

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The purpose of this book is to give a systematic account of the mathematical theory in this field as applied to problems of hypothesis testing. The resulting methods are predominantly sequential probability ratio tests. A brief account of classical tests under the neyman-pearson formulation is included. The notion of sequential analysis has been used in some form or other in various branches of statistical inference. We may classify these branches into three broad categories: Statistical tests of hypotheses, statistical estimation, and statistical decision theory.