[PDF] A Control Theoretic Approach To Dynamic Optimization Of Metabolic Networks eBook

Author : Costas D. Maranas
Publisher : John Wiley & Sons
Page : 278 pages
File Size : 18,48 MB
Release : 2016-02-23
Category : Science
ISBN : 1119028493

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Provides a tutorial on the computational tools that use mathematical optimization concepts and representations for the curation, analysis and redesign of metabolic networks Organizes, for the first time, the fundamentals of mathematical optimization in the context of metabolic network analysis Reviews the fundamentals of different classes of optimization problems including LP, MILP, MLP and MINLP Explains the most efficient ways of formulating a biological problem using mathematical optimization Reviews a variety of relevant problems in metabolic network curation, analysis and redesign with an emphasis on details of optimization formulations Provides a detailed treatment of bilevel optimization techniques for computational strain design and other relevant problems

Author : Jemal H. Abawajy
Publisher : Springer Nature
Page : 1144 pages
File Size : 42,84 MB
Release : 2020-08-12
Category : Computers
ISBN : 3030539806

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This book presents innovative ideas, cutting-edge findings, and novel techniques, methods, and applications in a broad range of cybersecurity and cyberthreat intelligence areas. As our society becomes smarter, there is a corresponding need to secure our cyberfuture. The book describes approaches and findings that are of interest to business professionals and governments seeking to secure our data and underpin infrastructures, as well as to individual users.

Author : Walerian Kipiniak
Publisher :
Page : 244 pages
File Size : 29,34 MB
Release : 2013-03
Category :
ISBN : 9781258597122

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M.I.T. Press Research Monographs, No. 12.

Author : E. N. Pistikopoulos
Publisher : Elsevier
Page : 2087 pages
File Size : 18,53 MB
Release : 2011-07-21
Category : Science
ISBN : 044453895X

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The European Symposium on Computer Aided Process Engineering (ESCAPE) series presents the latest innovations and achievements of leading professionals from the industrial and academic communities. The ESCAPE series serves as a forum for engineers, scientists, researchers, managers and students to present and discuss progress being made in the area of computer aided process engineering (CAPE). European industries large and small are bringing innovations into our lives, whether in the form of new technologies to address environmental problems, new products to make our homes more comfortable and energy efficient or new therapies to improve the health and well being of European citizens. Moreover, the European Industry needs to undertake research and technological initiatives in response to humanity's "Grand Challenges," described in the declaration of Lund, namely, Global Warming, Tightening Supplies of Energy, Water and Food, Ageing Societies, Public Health, Pandemics and Security. Thus, the Technical Theme of ESCAPE 21 will be "Process Systems Approaches for Addressing Grand Challenges in Energy, Environment, Health, Bioprocessing & Nanotechnologies."

Author : Florentino Fdez-Riverola
Publisher : Springer
Page : 346 pages
File Size : 48,35 MB
Release : 2017-06-19
Category : Technology & Engineering
ISBN : 3319608169

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Biological and biomedical research are increasingly driven by experimental techniques that challenge our ability to analyse, process and extract meaningful knowledge from the underlying data. The impressive capabilities of next-generation sequencing technologies, together with novel and constantly evolving, distinct types of omics data technologies, have created an increasingly complex set of challenges for the growing fields of Bioinformatics and Computational Biology. The analysis of the datasets produced and their integration call for new algorithms and approaches from fields such as Databases, Statistics, Data Mining, Machine Learning, Optimization, Computer Science and Artificial Intelligence. Clearly, Biology is more and more a science of information and requires tools from the computational sciences. In the last few years, we have seen the rise of a new generation of interdisciplinary scientists with a strong background in the biological and computational sciences. In this context, the interaction of researchers from different scientific fields is, more than ever, of foremost importance in boosting the research efforts in the field and contributing to the education of a new generation of Bioinformatics scientists. The PACBB’17 conference was intended to contribute to this effort and promote this fruitful interaction, with a technical program that included 39 papers spanning many different sub-fields in Bioinformatics and Computational Biology. Further, the conference promoted the interaction of scientists from diverse research groups and with a distinct background (computer scientists, mathematicians, biologists).

Author : Néstor V. Torres
Publisher : Cambridge University Press
Page : 328 pages
File Size : 25,47 MB
Release : 2002-12-19
Category : Science
ISBN : 9781139437615

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Facility in the targeted manipulation of the genetic and metabolic composition of organisms, combined with unprecedented computational power, is forging a niche for a new subspecialty of biotechnology called metabolic engineering. First published in 2002, this book introduces researchers and advanced students in biology and engineering to methods of optimizing biochemical systems of biotechnological relevance. It examines the development of strategies for manipulating metabolic pathways, demonstrates the need for effective systems models, and discusses their design and analysis, while placing special emphasis on optimization. The authors propose power-law models and methods of biochemical systems theory toward these ends. All concepts are derived from first principles, and the text is richly illustrated with numerous graphs and examples throughout. Special features include: nontechnical and technical introductions to models of biochemical systems; a review of basic methods of model design and analysis; concepts of optimization; and detailed case studies.

Author : Jörg Schwender
Publisher : Springer Science & Business Media
Page : 342 pages
File Size : 11,43 MB
Release : 2009-06-12
Category : Science
ISBN : 0387787453

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Plants are the basis for human nutrition and of increasing interest for the chemical industry as a source of chemical feed stocks. Fuels derived from plant biomass will increasingly replace fossil fuels in the future. In order to increase crop productivity, design new plant products, and create new energy crops, there is need for methods of qualitative and quantitative analysis of metabolism which are able to guide the rational re-design of metabolic networks. In this book, recent advances in qualitative and quantitative analysis of metabolism are summarized to give an overview of the current state of knowledge. Principles of the analysis of network structure, flux analysis, and kinetic modeling are described. Analytical methods necessary to produce the data needed for metabolic flux analysis and for kinetic modeling are described. The analysis of larger metabolic networks is only possible by using computer assistance. Therefore each chapter of the book shall also describe software available for this purpose.

Author : Alan Hastings
Publisher : Univ of California Press
Page : 848 pages
File Size : 20,36 MB
Release : 2012-05-31
Category : Nature
ISBN : 0520269659

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"A bold and successful attempt to illustrate the theoretical foundations of all of the subdisciplines of ecology, including basic and applied, and extending through biophysical, population, community, and ecosystem ecology. Encyclopedia of Theoretical Ecology is a compendium of clear and concise essays by the intellectual leaders across this vast breadth of knowledge."--Harold Mooney, Stanford University "A remarkable and indispensable reference work that also is flexible enough to provide essential readings for a wide variety of courses. A masterful collection of authoritative papers that convey the rich and fundamental nature of modern theoretical ecology."--Simon A. Levin, Princeton University "Theoretical ecologists exercise their imaginations to make sense of the astounding complexity of both real and possible ecosystems. Imagining a real or possible topic left out of the Encyclopedia of Theoretical Ecology has proven just as challenging. This comprehensive compendium demonstrates that theoretical ecology has become a mature science, and the volume will serve as the foundation for future creativity in this area."--Fred Adler, University of Utah "The editors have assembled an outstanding group of contributors who are a great match for their topics. Sometimes the author is a key, authoritative figure in a field; and at other times, the author has enough distance to convey all sides of a subject. The next time you need to introduce ecology students to a theoretical topic, you'll be glad to have this encyclopedia on your bookshelf."--Stephen Ellner, Cornell University “Everything you wanted to know about theoretical ecology, and much that you didn’t know you needed to know but will now! Alan Hastings and Louis Gross have done us a great service by bringing together in very accessible form a huge amount of information about a broad, complicated, and expanding field.”--Daniel Simberloff, University of Tennessee, Knoxville