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Author : Casey Lynnette Overby
Publisher :
Page : 371 pages
File Size : 23,96 MB
Release : 2011
Category :
ISBN :
Author : Beth Devine
Publisher : Academic Press
Page : 300 pages
File Size : 47,58 MB
Release : 2022-06-14
Category : Medical
ISBN : 0128244542
Clinical Decision Support for Pharmacogenomic Precision Medicine: Foundations and Implementation offers overviews, methods and strategies for translating genomic medicine to clinical practice. The book's authors explore incorporating pharmacogenetics into electronic health records, CDS methods and infrastructure for delivery, economic evaluation, the hospital administrations’ role and needs in integration, and patient counseling aspects. The book empowers clinicians, researchers, translational scientists, and data and IT experts to effectively navigate the complex landscape of CDS for pharmacogenomic precision medicine. Illustrative case studies of existing gene networks include CSER, eMERGE, the IGNITE network, DIGITIZE, the CDS Learning Network (RTI), ClinGen, Ubiquitous and CDS Hooks. Offers an applied, case-driven discussion of CDS for pharmacogenomic precision medicine Illustrates key concepts, contemporary developments, and future directions using examples of existing gene networks Features contributions from leading voices in precision medicine and clinical decision support
Author : Maher Khelifi
Publisher :
Page : 42 pages
File Size : 40,29 MB
Release : 2015
Category :
ISBN :
The use of pharmacogenomics (PGx)in clinical practice is still facing several challenges in reaching full adoption. PGx is an emerging field that aims to deploy genetic information to target drug therapy. To incorporate this science into clinical practice, many support the use of Pharmacogenomics Clinical Decision Support Systems (PGx-CDS) for medication prescriptions. This interest emerged with the new guidelines developed to incorporate genetics to optimize drug dosage and reduce adverse events. In my thesis, I investigate the development of PGx-CDS to (1) identify challenges and barriers of the implementation of PGx-CDS in clinical settings, (2) develop a new design approach of CDS with functional characteristics that can improve the adoption of Pharmacogenomics guidelines and improve patient safety, and (3) create design guidelines and recommendations. Through this work, I aim to study the implementation of PGx-CDS and develop design features that can overcome the challenges of its adoption in clinical settings.
Author : Chris Meyer
Publisher : Currency
Page : 288 pages
File Size : 19,37 MB
Release : 2003-05-13
Category : Business & Economics
ISBN : 1400050391
Why we are on the cusp of a new economic era that will make the changes and challenges of the Information Era seem like child’s play From the bestselling authors of Blur—a defining book of the Information Age—comes a startling glimpse into the near future and the emerging economy that awaits us. It’s Alive foretells the jolt the world is about to receive as the science of molecular evolution races out of the laboratories and into the business world. Think back to the early 1970s. Imagine the opportunities for your business, career choice, and investments had you received an advance report on the ways in which computer and information technology would revolutionize the world. It’s Alive provides that opportunity today: a realistic and persuasive look into the future—the molecular economy—and how it is starting to overtake and reshape the Information Age. Today’s gene mapping and molecular engineering are equivalent to the introduction of transistor radios at the advent of the information economy. Solid-state technology moved from the labs into the business arena, providing in turn the transistor, the microprocessor, and the modem—and the information business. During the next ten years, molecular technology will follow the same pattern, moving from the lab and into the basic operation of the corporation itself. Chris Meyer and Stan Davis are our guides in understanding this new future. They show that not only biological systems evolve. The rules of evolution help explain the process of change in biology, business, and the economy, thereby providing a management guide to the business world around the corner. It’s Alive is not science fiction or futurism. It bases its insights and predictions on the impact the molecular economy is already having in such diverse business environments as manufacturing, financial services, and energy. Through in-depth case studies of Capital One Financial, the U.S. Marine Corps, British Petroleum, and the biotech firm Maxygen, Meyer and Davis show how adaptive behavior works in the real world. As the rules of evolution combine with the connected economy, our business world will become unpredictable, volatile, and continually adaptive—in other words, alive. Also available as an eBook.
Author : Yui-Wing Francis Lam
Publisher : Academic Press
Page : 515 pages
File Size : 13,89 MB
Release : 2013-02-12
Category : Science
ISBN : 0123983037
Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation includes discussions and viewpoints from the academic, regulatory, pharmaceutical, clinical, socio-ethical and economic perspectives. Each chapter presents an overview of the potential or opportunity within the areas discussed and also outlines foreseeable challenges and limitations in moving pharmacogenomics into drug development and direct therapeutic applications. This edited book contains review questions for a more in-depth analysis of the implications of pharmacogenomics and discussion points to generate ideas on best to move the field forward. Clinical pearls and case studies are used to illustrate real-life experiences and both successful and unsuccessful applications. Tables, figures, and annotations are included throughout the book to facilitate understanding and further reference. Multi-contributed book and chapters are written by contributors who are experts in their field Provides perspectives from those involved in all aspects of pharmacogenomics—including academic, regulatory, economic, industry and medical—to illustrate how all of the pieces fit together and where the challenges may be Includes case studies of both successful and unsuccessful applications so readers can consider the potential and challenges in moving the science into drug development and direct therapeutic applications Chapters contain discussion questions and clinical pearls and enable readers to reflect on how to move pharmacogenomics forward and apply these observations and useful tips to their own work and research
Author : Kewal K. Jain
Publisher : Humana Press
Page : 762 pages
File Size : 19,99 MB
Release : 2015-03-17
Category : Medical
ISBN : 1493925539
Advances in the technology used in personalized medicine and increased applications for clinical use have created a need for this expansion and revision of Kewal K. Jain’s Textbook of Personalized Medicine. As the first definitive work on this topic, this book reviews the fundamentals and development of personalized medicine and subsequent adoptions of the concepts by the biopharmaceutical industry and the medical profession. It also discusses examples of applications in key therapeutic areas, as well as ethical and regulatory issues, providing a concise and comprehensive source of reference for those involved in healthcare management, planning and politics. Algorithms are included as a guide to those involved in the management of important diseases where decision-making is involved due to the multiple choices available. Textbook of Personalized Medicine, Second Edition will serve as a convenient source of information for physicians, scientists, decision makers in the biopharmaceutical and healthcare industries and interested members of the public.
Author : Geoffrey S. Ginsburg
Publisher : Academic Press
Page : 379 pages
File Size : 45,43 MB
Release : 2022-04-09
Category : Science
ISBN : 0128006536
Genomic and Precision Medicine: Oncology, Third Edition focuses on the applications of genome discovery as research points to personalized cancer therapies. Each chapter is organized to cover the application of genomics and personalized medicine tools and technologies to a) Risk Assessment and Susceptibility, b) Diagnosis and Prognosis, c) Pharmacogenomics and Precision Therapeutics, and d) Emerging and Future Opportunities in the field. Provides a comprehensive volume written and edited by oncology genomic specialists for oncology health providers Includes succinct commentary and key learning points that will assist providers with their local needs for implementation of genomic and personalized medicine into practice Presents an up-to-date overview on major opportunities for genomic and personalized medicine in practice Covers case studies that highlight the practical use of genomics in the management of patients
Author : Ernst R. Berndt
Publisher : University of Chicago Press
Page : 361 pages
File Size : 17,18 MB
Release : 2019-04-22
Category : Business & Economics
ISBN : 022661123X
Personalized and precision medicine (PPM)—the targeting of therapies according to an individual’s genetic, environmental, or lifestyle characteristics—is becoming an increasingly important approach in health care treatment and prevention. The advancement of PPM is a challenge in traditional clinical, reimbursement, and regulatory landscapes because it is costly to develop and introduces a wide range of scientific, clinical, ethical, and socioeconomic issues. PPM raises a multitude of economic issues, including how information on accurate diagnosis and treatment success will be disseminated and who will bear the cost; changes to physician training to incorporate genetics, probability and statistics, and economic considerations; questions about whether the benefits of PPM will be confined to developed countries or will diffuse to emerging economies with less developed health care systems; the effects of patient heterogeneity on cost-effectiveness analysis; and opportunities for PPM’s growth beyond treatment of acute illness, such as prevention and reversal of chronic conditions. This volume explores the intersection of the scientific, clinical, and economic factors affecting the development of PPM, including its effects on the drug pipeline, on reimbursement of PPM diagnostics and treatments, and on funding of the requisite underlying research; and it examines recent empirical applications of PPM.
Author : Michael S. Wogalter
Publisher : CRC Press
Page : 365 pages
File Size : 17,41 MB
Release : 1999-09-09
Category : Technology & Engineering
ISBN : 0203983831
Questions regarding how best to communicate warnings and risk information, whether such communications are likely to be effective, and what factors influence the communication process are important across many of society's facets today. Stimulated by the tremendous growth in litigation on product liability and associated personal injury, research i
Author : Michael Mahler
Publisher : Academic Press
Page : 300 pages
File Size : 23,97 MB
Release : 2021-03-12
Category : Science
ISBN : 032385432X
Precision Medicine and Artificial Intelligence: The Perfect Fit for Autoimmunity covers background on artificial intelligence (AI), its link to precision medicine (PM), and examples of AI in healthcare, especially autoimmunity. The book highlights future perspectives and potential directions as AI has gained significant attention during the past decade. Autoimmune diseases are complex and heterogeneous conditions, but exciting new developments and implementation tactics surrounding automated systems have enabled the generation of large datasets, making autoimmunity an ideal target for AI and precision medicine. More and more diagnostic products utilize AI, which is also starting to be supported by regulatory agencies such as the Food and Drug Administration (FDA). Knowledge generation by leveraging large datasets including demographic, environmental, clinical and biomarker data has the potential to not only impact the diagnosis of patients, but also disease prediction, prognosis and treatment options. Allows the readers to gain an overview on precision medicine for autoimmune diseases leveraging AI solutions Provides background, milestone and examples of precision medicine Outlines the paradigm shift towards precision medicine driven by value-based systems Discusses future applications of precision medicine research using AI Other aspects covered in the book include regulatory insights, data analytics and visualization, types of biomarkers as well as the role of the patient in precision medicine