[PDF] Transplantation In The Mammalian Cns eBook

Author :
Publisher : Elsevier
Page : 697 pages
File Size : 34,40 MB
Release : 1988-12-01
Category : Medical
ISBN : 0080862039

GET BOOK

Transplantation into the Mammalian CNS

Author : William J. Freed
Publisher : MIT Press
Page : 590 pages
File Size : 31,86 MB
Release : 2000
Category : Central nervous system
ISBN : 9780262062084

GET BOOK

After providing basic background on transplantation, brain structure, and development, the book discusses Parkinson's disease, the use of transplants to influence localized brain functions, circuit reconstruction, and genetic engineering and other future technologies.

Author : John R. Sladek
Publisher : Springer Science & Business Media
Page : 468 pages
File Size : 30,26 MB
Release : 2013-11-11
Category : Medical
ISBN : 1468446851

GET BOOK

The story of mammalian neural transplantation really begins eighty-one years ago. In Chicago in December of 1903, a 34-year-old physician, Elizabeth Hopkins Dunn, working as a research assistant in neurology, initiated a series of experiments to examine the ability of neonatal rat cerebral tissue to survive transplantation into the brain of matched littermates. Out of 46 attempts, four clearly successful grafts were identified. The publication of Dunn's results in 1917, the first credible report to demonstrate the feasibility of mammalian CNS transplants, generated little interest. In fact, the next significant experiment in this field did not appear until 1930. The field continued to grow slowly and quietly as investigators gradually realized the value of neural trans plantation to study problems of development and plasticity in the mammalian nervous system. With the discovery in 1979 that grafted neurons were capable of appropriate and functional interactions with the host brain, interest in neural transplantation esca lated sharply. The extraordinary opportunities created by using functional neural trans plants in investigating basic issues in neurobiology, as well as the clinical implications, excited both scientists and the public. The popularity of neural transplantation has been growing rapidly in the past five years and shows no signs of abating. The present volume was designed to meet two needs created by the rapid growth of this subdiscipline of neurobiology. The first was to provide a thorough review of the experimental foundations of neural transplantation.

Author : Dorothy E. Oorschot
Publisher : Springer Science & Business Media
Page : 196 pages
File Size : 26,52 MB
Release : 2012-12-06
Category : Medical
ISBN : 3642751083

GET BOOK

This state-of-the-art review links the experimental data into a cohesive and critical account of CNS regeneration. Research findings are discussed in terms of their relevance to one (or more) of thirteen hypotheses concerned with regeneration in the mammalian CNS. Research findings reviewed include: regeneration in developing mammals and in submammalian vertebrates, the use of transplants and/or pharmacological treatments, in vitro studies on neurotrophic and neurite promoting factors and their potential relevance to CNS regeneration in vivo, and in vitro studies on the types of glial cells that may be responsible for enhancing or suppressing axonal re-growth.

Author : Thomas B. Freeman
Publisher : Springer Science & Business Media
Page : 376 pages
File Size : 47,35 MB
Release : 1998-05-29
Category : Medical
ISBN :

GET BOOK

In Cell Transplantation for Neurological Disorders, distinguished medical researchers from around the world review novel neural reconstructive techniques that appear to be beneficial for Parkinson's disease and hold promise for treating Huntington's disease, pain, demyelinating diseases, stroke, and epilepsy. The contributors focus on those diseases for which clinical trials are either ongoing or likely to occur in the near future. Among the topics reviewed are results and rationale for some of the leading transplant programs for the treatment of Parkinson's disease, the use of PET scanning for patient evaluation, autopsy studies of transplant recipients, transplant immunology, fetal tissue transplantation for Huntington's disease, cellular transplantation for the treatment of pain and stroke, and transplantation of myelinating cells. A full discussion of the important ethical issues surrounding the use of fetal tissue for transplantation purposes is also included. Cell Transplantation for Neurological Disorders is the first major book on the clinical use of neural reconstruction techniques. Authoritative and comprehensive, the book reviews the field at a critical threshold, evaluating those variables that will become critical as the methodology and favorable outcomes mature.