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Author : Samuel Avery
Publisher :
Page : 225 pages
File Size : 35,37 MB
Release : 2013
Category : Nature
ISBN : 9780985574826
Explores the political, social, economic, and ecological issues that underlie the Keystone XL pipeline project, an endeavor that would release enough carbon into the atmosphere to drastically hasten climate change.
Author : Steven P. Gunn
Publisher :
Page : 138 pages
File Size : 42,20 MB
Release : 1973
Category : Attitude change
ISBN :
Author : Tony Oppedisano
Publisher : Simon and Schuster
Page : 320 pages
File Size : 32,90 MB
Release : 2021-06-08
Category : Biography & Autobiography
ISBN : 1982151781
From Sinatra's closest confidant and an eventual member of his management team, Tony Oppedisano, comes an extraordinarily intimate look at the singing idol. Deep into the night, for more than two thousand nights, Frank and Tony would converse, about music, family, friends, great loves, achievements and successes, failures and disappointments, the lives they'd led, the lives they wished they'd led
Author : Steven Piantadosi
Publisher : John Wiley & Sons
Page : 918 pages
File Size : 17,34 MB
Release : 2017-10-09
Category : Mathematics
ISBN : 1118959213
Presents elements of clinical trial methods that are essential in planning, designing, conducting, analyzing, and interpreting clinical trials with the goal of improving the evidence derived from these important studies This Third Edition builds on the text’s reputation as a straightforward, detailed, and authoritative presentation of quantitative methods for clinical trials. Readers will encounter the principles of design for various types of clinical trials, and are then skillfully guided through the complete process of planning the experiment, assembling a study cohort, assessing data, and reporting results. Throughout the process, the author alerts readers to problems that may arise during the course of the trial and provides common sense solutions. All stages of therapeutic development are discussed in detail, and the methods are not restricted to a single clinical application area. The authors bases current revisions and updates on his own experience, classroom instruction, and feedback from teachers and medical and statistical professionals involved in clinical trials. The Third Edition greatly expands its coverage, ranging from statistical principles to new and provocative topics, including alternative medicine and ethics, middle development, comparative studies, and adaptive designs. At the same time, it offers more pragmatic advice for issues such as selecting outcomes, sample size, analysis, reporting, and handling allegations of misconduct. Readers familiar with the First and Second Editions will discover revamped exercise sets; an updated and extensive reference section; new material on endpoints and the developmental pipeline, among others; and revisions of numerous sections. In addition, this book: • Features accessible and broad coverage of statistical design methods—the crucial building blocks of clinical trials and medical research -- now complete with new chapters on overall development, middle development, comparative studies, and adaptive designs • Teaches readers to design clinical trials that produce valid qualitative results backed by rigorous statistical methods • Contains an introduction and summary in each chapter to reinforce key points • Includes discussion questions to stimulate critical thinking and help readers understand how they can apply their newfound knowledge • Provides extensive references to direct readers to the most recent literature, and there are numerous new or revised exercises throughout the book Clinical Trials: A Methodologic Perspective, Third Edition is a textbook accessible to advanced undergraduate students in the quantitative sciences, graduate students in public health and the life sciences, physicians training in clinical research methods, and biostatisticians and epidemiologists. This book is accompanied by downloadable files available below under the DOWNLOADS tab. These files include: MATHEMATICA program – A set of downloadable files that tracks the chapters, containing code pertaining to each. SAS PROGRAMS and DATA FILES used in the book. The following software programs, included in the downloadables, were developed by the author, Steven Piantadosi, M.D., Ph.D: RANDOMIZATION – This program generates treatment assignments for a clinical trial using blocked stratified randomization. CRM – Implements the continual reassessment methods for dose finding clinical trials. OPTIMAL – Calculates two-stage optimal phase II designs using the Simon method. POWER – This is a power and sample size program for clinical trials. Executables for installing these programs can also be found at https://risccweb.csmc.edu/biostats/. Steven Piantadosi, MD, PhD, is the Phase One Foundation Distinguished Chair and Director of the Samuel Oschin Cancer Institute, and Professor of Medicine at Cedars-Sinai Medical Center in Los Angeles, California. Dr. Piantadosi is one of the world’s leading experts in the design and analysis of clinical trials for cancer research. He has taught clinical trials methods extensively in formal courses and short venues. He has advised numerous academic programs and collaborations nationally regarding clinical trial design and conduct, and has served on external advisory boards for the National Institutes of Health and other prominent cancer programs and centers. The author of more than 260 peer-reviewed scientific articles, Dr. Piantadosi has published extensively on research results, clinical applications, and trial methodology. While his papers have contributed to many areas of oncology, he has also collaborated on diverse studies outside oncology including lung disease and degenerative neurological disease.
Author : Alexey Stakhov
Publisher : World Scientific
Page : 331 pages
File Size : 37,35 MB
Release : 2020-09-03
Category : Mathematics
ISBN : 9811213488
Volume II is the second part of the 3-volume book Mathematics of Harmony as a New Interdisciplinary Direction and 'Golden' Paradigm of Modern Science. 'Mathematics of Harmony' rises in its origin to the 'harmonic ideas' of Pythagoras, Plato and Euclid, this 3-volume book aims to promote more deep understanding of ancient conception of the 'Universe Harmony,' the main conception of ancient Greek science, and implementation of this conception to modern science and education.This 3-volume book is a result of the authors' research in the field of Fibonacci numbers and the Golden Section and their applications. It provides a broad introduction to the fascinating and beautiful subject of the 'Mathematics of Harmony,' a new interdisciplinary direction of modern science. This direction has many unexpected applications in contemporary mathematics (a new approach to a history of mathematics, the generalized Fibonacci numbers and the generalized golden proportions, the generalized Binet's formulas), theoretical physics (new hyperbolic models of Nature) and computer science (algorithmic measurement theory, number systems with irrational bases, Fibonacci computers, ternary mirror-symmetrical arithmetic).The books are intended for a wide audience including mathematics teachers of high schools, students of colleges and universities and scientists in the field of mathematics, theoretical physics and computer science. The book may be used as an advanced textbook by graduate students and even ambitious undergraduates in mathematics and computer science.
Author : Armelle Corre
Publisher : Springer Science & Business Media
Page : 219 pages
File Size : 26,87 MB
Release : 2006-06-15
Category : Science
ISBN : 0387238433
Provides first time integrated approach to R and D-project, -pipeline and -department management from a micro-, meso- and macroscopic view. Derives 21 easy and ready to apply rules for a better design and a superior control of R and D without losinf sight of high scientific standards.
Author : Fei Liu
Publisher : Springer Nature
Page : 885 pages
File Size : 44,21 MB
Release : 2023-11-08
Category : Computers
ISBN : 3031446968
This three-volume set constitutes the refereed proceedings of the 12th National CCF Conference on Natural Language Processing and Chinese Computing, NLPCC 2023, held in Foshan, China, during October 12–15, 2023. The ____ regular papers included in these proceedings were carefully reviewed and selected from 478 submissions. They were organized in topical sections as follows: dialogue systems; fundamentals of NLP; information extraction and knowledge graph; machine learning for NLP; machine translation and multilinguality; multimodality and explainability; NLP applications and text mining; question answering; large language models; summarization and generation; student workshop; and evaluation workshop.
Author : Anita Wadhwa
Publisher : Routledge
Page : 187 pages
File Size : 49,18 MB
Release : 2015-11-19
Category : Education
ISBN : 1317434463
The school-to-prison pipeline is often the path for marginalized students, particularly black males, who are three times as likely to be suspended as White students. This volume provides an ethnographic portrait of how educators can implement restorative justice to build positive school cultures and address disciplinary problems in a more corrective and less punitive manner. Looking at the school-to-prison pipeline in a historical context, it analyzes current issues facing schools and communities and ways that restorative justice can improve behavior and academic achievement. By practicing a critical restorative justice, educators can reduce the domino effect between suspension and incarceration and foster a more inclusive school climate.
Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
Page : 145 pages
File Size : 39,27 MB
Release : 2018-02-12
Category : Medical
ISBN : 0309457971
Advances in cancer research have led to an improved understanding of the molecular mechanisms underpinning the development of cancer and how the immune system responds to cancer. This influx of research has led to an increasing number and variety of therapies in the drug development pipeline, including targeted therapies and associated biomarker tests that can select which patients are most likely to respond, and immunotherapies that harness the body's immune system to destroy cancer cells. Compared with standard chemotherapies, these new cancer therapies may demonstrate evidence of benefit and clearer distinctions between efficacy and toxicity at an earlier stage of development. However, there is a concern that the traditional processes for cancer drug development, evaluation, and regulatory approval could impede or delay the use of these promising cancer treatments in clinical practice. This has led to a number of effortsâ€"by patient advocates, the pharmaceutical industry, and the Food and Drug Administration (FDA)â€"to accelerate the review of promising new cancer therapies, especially for cancers that currently lack effective treatments. However, generating the necessary data to confirm safety and efficacy during expedited drug development programs can present a unique set of challenges and opportunities. To explore this new landscape in cancer drug development, the National Academies of Sciences, Engineering, and Medicine developed a workshop held in December 2016. This workshop convened cancer researchers, patient advocates, and representatives from industry, academia, and government to discuss challenges with traditional approaches to drug development, opportunities to improve the efficiency of drug development, and strategies to enhance the information available about a cancer therapy throughout its life cycle in order to improve its use in clinical practice. This publication summarizes the presentations and discussions from the workshop.
Author : Wolfgang Banzhaf
Publisher : Springer
Page : 234 pages
File Size : 24,44 MB
Release : 2019-01-23
Category : Computers
ISBN : 3030047350
These contributions, written by the foremost international researchers and practitioners of Genetic Programming (GP), explore the synergy between theoretical and empirical results on real-world problems, producing a comprehensive view of the state of the art in GP. Topics in this volume include: evolving developmental programs for neural networks solving multiple problems, tangled program, transfer learning and outlier detection using GP, program search for machine learning pipelines in reinforcement learning, automatic programming with GP, new variants of GP, like SignalGP, variants of lexicase selection, and symbolic regression and classification techniques. The volume includes several chapters on best practices and lessons learned from hands-on experience. Readers will discover large-scale, real-world applications of GP to a variety of problem domains via in-depth presentations of the latest and most significant results.