[PDF] Studies On Key Developmental Regulatory Mechanisms Associated With Dopaminergic Neuron During Degeneration And Regeneration eBook

Author : Tippabathani Jayakrishna S
Publisher : Independent Author
Page : 0 pages
File Size : 36,93 MB
Release : 2023-03-19
Category : Education
ISBN : 9781805251316

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Dopamine (DA) is involved in many metabolic and regulating functions such as reward, motivation, memory, attention, and regulating body movements. In the mammalian central nervous system (CNS), mesencephalic dopaminergic (mDA) neurons are the main source of dopamine (Holzschuh et al., 2001). The selective loss of mDA neurons of the substantia nigra pars compacta (SNpc) is the hallmark of Parkinson's disease (PD) (DeMaagd and Philip, 2015). PD is associated with impairment of cognitive capabilities and symptoms like bradykinesia, tremor, and akinesia. Scientific reports are working to decipher the cellular and molecular mechanisms driving PD pathogenesis, as it is not well understood. Symptoms manifest only after 70-80% of mDA neurons have been degenerated (Cheng et al., 2010) and may be devastating because the adult CNS has extremely limited intrinsic regeneration to replace the lost neurons (Horner and Gage, 2000). Unfortunately, the loss of DA neurons cannot be rescued or reversed by drug administration. It is mandatory to decipher the neurogenesis and their mechanism, as they assist the scientific community towards inducing human stem cells to express a dopaminergic phenotype.

Author : James A. Radosevich
Publisher : John Wiley & Sons
Page : 768 pages
File Size : 38,18 MB
Release : 2018-09-18
Category : Science
ISBN : 1119432359

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These volumes teach readers to think beyond apoptosis and describes all of the known processes that cells can undergo which result in cell death This two-volume source on how cells dies is the first, comprehensive collection to cover all of the known processes that cells undergo when they die. It is also the only one of its kind to compare these processes. It seeks to enlighten those in the field about these many processes and to stimulate their thinking at looking at these pathways when their research system does not show signs of activation of the classic apoptotic pathway. In addition, it links activities like the molecular biology of one process (eg. Necrosis) to another process (eg. apoptosis) and contrasts those that are close to each. Volume 1 of Apoptosis and Beyond: The Many Ways Cells Die begins with a general view of the cytoplasmic and nuclear features of apoptosis. It then goes on to offer chapters on targeting the cell death mechanism; microbial programmed cell death; autophagy; cell injury, adaptation, and necrosis; necroptosis; ferroptosis; anoikis; pyronecrosis; and more. Volume 2 covers such subjects as phenoptosis; pyroptosis; hematopoiesis and eryptosis; cyclophilin d-dependent necrosis; and the role of phospholipase in cell death. Covers all known processes that dying cells undergo Provides extensive coverage of a topic not fully covered before Offers chapters written by top researchers in the field Provides activities that link and contrast processes to each other Apoptosis and Beyond: The Many Ways Cells Die will appeal to students and researchers/clinicians in cell biology, molecular biology, oncology, and tumor biology.

Author : Elisabetta Babetto
Publisher : Humana
Page : 0 pages
File Size : 36,89 MB
Release : 2020-06-11
Category : Science
ISBN : 9781071605844

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This book is a collection of classical as well as innovative methods used to investigate axon degeneration with a particular focus on addressing the common challenges encountered while performing these procedures. Particular attention is devoted to the study of axon loss in several model organisms, as each poses unique challenges and provides powerful advantages. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Axon Degeneration: Methods and Protocols is an ideal guide for facilitating the application and further development of these protocols, which will help the scientific community tackle important questions regarding axon degeneration. Chapters 2, 3, and 20 are available Open Access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Author : Stephen G. Waxman
Publisher :
Page : 710 pages
File Size : 47,30 MB
Release : 1995
Category : Axons
ISBN : 0195082931

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The axon, interposed between the cell body and the synaptic terminals in most neurons, plays a crucial role in connecting neurons and acting as a conduit for the transmission of information between them. This book provides a comprehensive and up-to-date compendium that brings together chapterson the structure, function, and pathophysiology of axons in both the PNS and CNS. Carefully written, well-illustrated with superb illustrations, and generously referenced, the 33 chapters and introduction have been authored by 49 world-renowned authorities. Recent advances in the molecularneurobiology of axons are carefully reviewed, and new areas, such as the molecular biology of ion channels and myelination, the role of calcium in pathophysiology and regeneration, cell adhesion molecules and their roles in axo-glial interactions and axonal guidance, and optical recording methods,are highlighted. This book will provide an essential reference for neuroscientists as well as clinicians such as neurologists, neurosurgeons, and clinical electrophysiologists interested in axons.

Author : Santiago Ramón y Cajal
Publisher : History of Neuroscience
Page : 977 pages
File Size : 10,40 MB
Release : 1991
Category : Nervous system
ISBN : 0195065166

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This book is a reprint of an English translation of Cajal's original work, with abundant notes and commentaries by the editor. This text describes Cajal's fundamental contributions to neuroscience, which continue to be important today. It accurately details Cajal's ideas and data, and providesreaders with the opportunity to learn what Cajal thought about his research career and the significance of his observations. Excerpts from Tello's memorial lectures also provide a contemporary view of Cajal's work.

Author : Jun Chen
Publisher : Springer Science & Business Media
Page : 490 pages
File Size : 23,92 MB
Release : 2008-12-16
Category : Medical
ISBN : 1603271856

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Despite numerous recent studies and exciting discoveries in the field, only limited treatment is available today for the victims of acute neurological injuries. Animal Models of Acute Neurological Injuries provides a standardized methodology manual designed to eliminate the inconsistent preparations and variability that currently jeopardizes advances in the field. Contributed by top experts and many original developers of the models, each chapter contains a step-by-step, proven procedure and visual aids covering the most commonly used animal models of neurological injury in order to highlight the practical applications of animal models rather than the theoretical issues. This intensive volume presents its readily reproducible protocols with great clarity and consistency to best aid neuroscientists and neurobiologists in laboratory testing and experimentation. Comprehensive and cutting-edge, Animal Models of Acute Neurological Injuries is an ideal guide for scientists and researchers who wish to pursue this vital course of study with the proficiency and precision that the field requires.

Author : Daniel Laskowitz
Publisher : CRC Press
Page : 388 pages
File Size : 40,29 MB
Release : 2016-04-21
Category : Medical
ISBN : 1498766579

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Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme

Author : Andre M. Goffinet
Publisher : Springer Science & Business Media
Page : 347 pages
File Size : 36,33 MB
Release : 2012-08-10
Category : Science
ISBN : 3540480021

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Our understanding of the molecular mechanisms involved in mammalian brain development remains limited. However, the last few years have wit nessed a quantum leap in our knowledge, due to technological improve ments, particularly in molecular genetics. Despite this progress, the available body of data remains mostly phenomenological and reveals very little about the grammar that organizes the molecular dictionary to articulate a pheno type. Nevertheless, the recent progress in genetics will allow us to contem plate, for the first time, the integration of observation into a coherent view of brain development. Clearly, this may be a major challenge for the next century, and arguably is the most important task of contemporary develop mental biology. The purpose of the present book is to provide an overview that syn thesizes up-to-date information on selected aspects of mouse brain devel opment. Given the format, it was not possible to cover all aspects of brain development, and many important subjects are missing. The selected themes are, to a certain extent, subjective and reflect the interests of the contributing authors. Examples of major themes that are not covered are peripheral nervous system development, including myelination, the development of the hippocampus and several other CNS structures, as well as the developmental function of some important morphoregulatory molecules.

Author : Nancy Y. Ip
Publisher : Springer Science & Business Media
Page : 326 pages
File Size : 21,24 MB
Release : 2009-02-28
Category : Medical
ISBN : 0387788875

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Cyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation of neuronal survival during both developmental stages and in neurodegenerative diseases. These observations indicate that precise control of Cdk5 is essential for the regulation of neuronal survival. The pivotal role Cdk5 appears to play in both the regulation of neuronal survival and synaptic functions thus raises the interesting possibility that Cdk5 inhibitors may serve as therapeutic treatment for a number of neurodegenerative diseases.