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Intended for neurobiologists with an interest in mathematical analysis of neural data as well as the growing number of physicists and mathematicians interested in information processing by "real" nervous systems, Spikes provides a self-contained review of relevant concepts in information theory and statistical decision theory.
The story of a neural impulse and what it reveals about how our brains work We see the last cookie in the box and think, can I take that? We reach a hand out. In the 2.1 seconds that this impulse travels through our brain, billions of neurons communicate with one another, sending blips of voltage through our sensory and motor regions. Neuroscientists call these blips “spikes.” Spikes enable us to do everything: talk, eat, run, see, plan, and decide. In The Spike, Mark Humphries takes readers on the epic journey of a spike through a single, brief reaction. In vivid language, Humphries tells the story of what happens in our brain, what we know about spikes, and what we still have left to understand about them. Drawing on decades of research in neuroscience, Humphries explores how spikes are born, how they are transmitted, and how they lead us to action. He dives into previously unanswered mysteries: Why are most neurons silent? What causes neurons to fire spikes spontaneously, without input from other neurons or the outside world? Why do most spikes fail to reach any destination? Humphries presents a new vision of the brain, one where fundamental computations are carried out by spontaneous spikes that predict what will happen in the world, helping us to perceive, decide, and react quickly enough for our survival. Traversing neuroscience’s expansive terrain, The Spike follows a single electrical response to illuminate how our extraordinary brains work.
This career-spanning monograph is a visual celebration of Spike Lee's life and career to date. Featuring hundreds of never-before-seen photographs by David Lee, Spike's brother, this book includes behind-the-scenes, insider images that underscore his creative process, and his significant impact on the culture at large. Print run 15,000.
SHORTLISTED FOR THE ORWELL PRIZE FOR POLITICAL WRITING 2022 THE TIMES SCIENCE BOOK OF THE YEAR A GUARDIAN BEST POLITICS BOOK OF THE YEAR A TOP 5 SUNDAY TIMES BESTSELLER *Revised and updated edition with new chapter reflecting on the impact of Covid-19 two years on, and what come next* Did the UK government really 'follow the science' throughout the Covid-19 pandemic, as it claims? As head of the Wellcome Trust, Jeremy Farrar was one of the first people in the world to hear about a mysterious new disease in China - and to learn it could readily spread between people. A member of the SAGE emergency committee, Farrar was a key figure in both the UK and the World Health Organization at the onset of the Covid-19 pandemic amid great uncertainty, fast-moving situations and missed opportunities. Spike is his widely acclaimed inside story. His account casts light on the UK government's claims to be 'following the science' and is informed not just by Farrar's views but by interviews with other top scientists and political figures.
Selected as one of baseball literature's Golden Dozen by Roger Kahn, Man on Spikes is an uncompromisingly realistic novel about a baseball player who struggles through sixteen years of personal crises and professional ordeals before finally appearing in a major league game. In a preface to this new edition, Eliot Asinof reveals the longsuffering ballplayer and friend upon which the novel is based.
“Jimmy Hatch is a personal hero of mine.” —Anderson Cooper “Irresistible. . . . A wounded SEAL’s shame becomes a salvation.” —J. Ford Huffman, Military Times James Hatch is a former special ops Navy SEAL senior chief, master naval parachutist, and expert military dog trainer and handler. On his fateful final mission in Afghanistan, his SEAL team was sent to recover Bowe Bergdahl—the soldier who deserted his post and fell into the hands of Al-Qaida and the Taliban. The mission went south, and Hatch was left with a shattered femur from an AK-47 round and the SEAL dog who fought alongside him was dead. As a result of his horrific leg wound, his twenty-four-year military career came to an end—and with it the only life he’d ever known. In Touching the Dragon, we witness his long road to recovery. Getting well physically required eighteen surgeries, twelve months of recovery, and learning to walk again. But getting well mentally would prove to be much tougher, as he fought through the depths of despair, alcoholism, and the pull to end his own life. What emerges is a different kind of hero’s journey, one in which Hatch shows the courage it takes to confess, confront, and overcome his own brokenness. Through the love of family, friends, and his military dogs, Hatch learned remarkable tools and found his purpose, and now he wants to share this wisdom with the rest of us because we all have wounds.
The nervous system of higher animals is very complex and highly nonlinear. among its many capabilities are making decisions and carrying out complex motor actions such as swimming. Nonlinear dynamical modelling can be used to understand and explain neural phenomena at many different levels, including - ion-currents and action potentials; short - and long - term memory; visual hallucinations; neural synchronization; motor control This book explores the mathematical principles by which brains generate spikes, make decisions, store memories, and control actions. It assumes a basic knowledge of calculus and develops the dynamical foundations of neuroscience using problem sets and computer simulations on the accompanying PC and Mac compatible MatLab disk.
Can an ugly dog with a heart of gold find a home? A warm and clever picture book for animal lovers of any breed. When Spike, the winner of the Ugliest Dog in the Universe contest, is abandoned by his owner, Joe, the boy next door, is determined—against all odds—to adopt him. Things look grim until Spike foils a neighborhood catnapping plan—and saves the day!
Watch out, BusyBugz - Spike is around and he's creating chaos! He flies off on silvery foil wings with lzzi's pollen bag, bursts Zed's golden foil ball, and spoils Ruby's garden of pink foil beans by upsetting her red foil cart. But with Mayday's help and a few fabulous foil tools, the wasp realizes that playing tricks is not the way to make friends, and does what he must to make amends.